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Elisabeth Hultgren-Hörnquist

Tjänstetitel: Professor Organisation: Institutionen för medicinska vetenskaper

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Elisabeth Hultgren-Hörnquist

Om Elisabeth Hultgren-Hörnquist

I performed my Ph.D. studies and defended my thesis in 1994 at University of Gothenburg. My thesis project involved T cell regulation of intestinal immune responses and the action of the mucosal adjuvant cholera toxin on mucosal T lymphocytes. A few months after that I was recruited to Baylor College of Medicine, Houston, TX for a postdoc covered by grants from the Crohn´s and Colitis Foundation of America (CCFA), working on the characterization of the, at that time, new mouse model of experimental colitis, deficient in the inhibitory G protein subunit Gi2 (Gi2-/- mice)which spontaneously develop chronic colitis, clinically and pathologically resembling UC. For a long time after this I was the only person keeping a colony of these mice as my boss left academia, and my laboratory has made several major discoveries in this model. With this work I also started a completely new field of research at the Department of Medical Microbiol. & Immunol., Göteborg Univ. I set up my own lab, completely independent from other senior scientists, including buying all the basic equipment. I became Associate Professor in 2001. I was also working as a Research & Development Coordinator at Clinical Immunology and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg between 2004 and 2007

Since returning from my postdoc in the USA I have recruited 7 Ph.D. students as main supervisor, six of which have finished and one will finish in February 2016. In addition I have been/am co-supervisor for three Ph.D. students in both Gothenburg and Örebro. I also have a technician in the group since 1998. In 2007 I accepted a Full Professorship in Immunology at Örebro University, where I am expanding the clinical angle of my research with studies in IBD and MC patients, while still continuing the mouse studies at Göteborg University. In Örebro I have recruited two postdocs; I. Rangel (part-time – also working with Robert Brummer), an expert on microbiota analysis and bioinformatics responsible for our microbiota studies and D. Bergemalm (part-time – being a M.D. resident within Gastroenterology), a proteomics expert and responsible for our fecal biomarker studies

In Örebro I collaborate with gastroenterologists Profs. C Tysk and R. Brummer and Assoc. Profs. J Bohr N. Nyhlin and J Halfvarson, all with good reputation from clinical research on MC and IBD. I also collaborate with Assoc. Prof. O. Hultgren on intracellular regulation of TLR signalling, and Prof. A Sirsjö on Vitamin A metabolism. In Göteborg I collaborate with Prof. P. Bland, a very experienced mucosal immunologist. At the Univ. of Skövde I collaborate with system biologist Dr. A Jansson who is a specialist in mathematical modeling of T cell biology[27].

I am part of the Swedish Organization for IBD studies (SOIBD), the national organization for research and education in IBD. I was also co-founder and co-director of Forum GIMIICum 2009-2014 (Director Prof. J. Söderholm - http://www.hu.liu.se/forum-gimiicum?l=en) a Swedish Research Council-funded translational national research school, with the objective to stimulate life-long careers with combined clinical practice and research within the areas of GI inflammation and infection. I am currently a member of the steering board.

I am part of a COST action (BM0806) on the histamine receptor H4R, where we elucidate the role of the H4R in colitis (www.histamineresearch.com)

My research have been/is enabled by grants from Medicinska Forskningsrådet (MFR)/Vetenskapsrådet (VR); The Cancerf Foundation; EU 5th Framework Program, The Knowledge Foundation, LUA-ALF Västra Götaland, Swedish Society of Medicine, Astra-Zeneca Research Grant; Junior Individual Grant, Swedish Foundation for Strategic Research; Nyckelfonden, Örebro; Project bound Ph.D. student grants, Medical Faculty, Univ. of Gothenburg, Project bound Ph.D. student grants, Örebro University. I currently have 47 peer-reviewed papers, 8 manuscripts and 5 conference contributions/proceedings/book chapters

I was recruited to the full professorship in Immunology at Örebro University in 2007 partly to help writing the application and setting up the Medical School. Our application, where I was in the core writing group, was approved in 2010 and we started the program in January 2011. Since then I have had several major positions including Director of Basic Sciences, Director of Theme Defence, member of the steering committee, member of the examination board. Before moving to Örebro, I have had substantial experience from teaching at Gothenburg University: I was Director of Studies for undergraduate studies in Immunology at Dept. of Clinical Immunology, Course leader for Immunology for Cell Biology students, Advanced Immunology, and Immunology, the two latter PBL-based courses, Examiner at oral examinations of medical, dental, natural science and biomedical analyst students. Extensive lecturing and seminar activities, as well as curriculum work for undergraduate and graduate medical and science students in Immunology. Supervisor of >15 students for their Bachelor and Master degree projects and Lecturer on graduate courses in Inflammation and Mucosal Immunology.

In Örebro I was also Course leader for the Immunology course for Biomedical students and Biomedical Analyst students, 2008-2009.

I have taken several courses including a Leadership Course, Örebro University 2012-2013 and several Pedagogic courses: “Problem-Based Learning”, Univ. of Maastricht 2010-11, ”Leadership Program - Couching Creativity”, MIVAC (Mucosal Immunobiology and Vaccine Center, Univ. of Gothenburg) 2006-07, ”Scientific supervision” 1998, Univ. of Gothenburg. ”Further Pedagogic training for teachers” Univ of Gothenburg, 1999.

I have been/am a member of MIVAC – Mucosal Immunobiology and Vaccine Center, Univ. of Gothenburg 2004-2010, NUPARC - The Örebro Nutrition and Physical Activity Research Centre for optimal health and functionality through life 2009-present, NGBI - The Nutrition-Gut-Brain Interactions Research Centre, Örebro University 2012-present and EMCG - The European Microscopic Colitis Group 2012-present.

Other commissions of trust include Expert Adviser for positions and promotions three times, and for grants applications to the Broad Medical Research Program (BMRP) twice, Opponent for thesis defence at Maastricht University and Karolinska Institute, Thesis evaluation committee member >20 times, Conferrer of doctor´s degrees, Örebro Univerity 2010, Ad hoc reviewer for a broad range of journals within Gastroenterology and Immunology, Member of Meda IBD Club with elected members only, working with gastroenterology and IBD in Sweden, Treasurer: SWIMM (Swedish society for Immunology) 2006-2008, Board member; Center for Gastroenterological Research (CGF), Göteborg Univ. 2000-05, organizer of a three-day symposium;”Immunological aspects on Inflammatory Bowel Disease”, 1997, and co-organizer of 2 symposia; “European Mucosal Immunology Group Meeting (EMIG)” October 2000 and ”Luminal factors in health and disease” 1998, Course leader of graduate course “Basic Gastroenterology” 2000, Invited speaker at >10 scientific meetings and Invited lecturer at >5 institutions in Sweden and abroad, and Oral presentation at >15 international immunology meetings, and “Evolution and Innovation in Problem-based Learning, England 2011.

Publikationer

Artiklar i tidskrifter |  Artiklar, forskningsöversikter |  Konferensbidrag |  Manuskript | 

Artiklar i tidskrifter

Gunaltay, S. , Rademacher, L. , Hultgren Hörnquist, E. & Bohr, J. (2017). Clinical and immunologic effects of faecal microbiota transplantation in a patient with collagenous colitis. World Journal of Gastroenterology, 23 (7), 1319-1324.
Fant, F. , Tina, E. , Andersson, S. O. , Magnuson, A. , Hultgren-Hörnquist, E. & Gupta, A. (2017). Early perioperative immunological effects of anaesthesia and analgesia in patients undergoing prostate cancer surgery: A randomised pilot study.. European Journal of Anaesthesiology, 34 (4), 241-243.
Bergemalm, D. , Kruse, R. , Sapnara, M. , Halfvarson, J. & Hultgren Hörnquist, E. (2017). Elevated fecal peptidase D at onset of colitis in Galphai2(-/-) mice, a mouse model of IBD. PLoS ONE, 12 (3).
Gunaltay, S. , Repsilber, D. , Helenius, G. , Nyhlin, N. , Bohr, J. , Hultgren, O. & Hultgren Hörnquist, E. (2017). Oligoclonal T-cell Receptor Repertoire in Colonic Biopsies of Patients with Microscopic Colitis and Ulcerative Colitis. Inflammatory Bowel Diseases, 23 (6), 932-945.
Günaltay, S. , Ghiboub, M. , Hultgren, O. & Hultgren Hörnquist, E. (2017). Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells. Digestive Diseases and Sciences, 62 (5), 1204-1215.
Rangel, I. , Ganda Mall, J. P. , Roger, W. , Sjöberg, F. & Hultgren-Hörnquist, E. (2016). Degree of colitis correlates with microbial composition and cytokine responses in colon and caecum of Gαi2-deficient mice. FEMS Microbiology Ecology, 92 (7).
Sundin, J. , Rangel, I. , Fuentes, S. , Jong, H. , Hultgren-Hörnquist, E. , de Vos, W. M. & Brummer, R. (2015). Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress. Alimentary Pharmacology and Therapeutics, 41 (4), 342-351.
Gunaltay, S. , Kumawat, A. K. , Nyhlin, N. , Bohr, J. , Tysk, C. , Hultgren, O. & Hultgren-Hörnquist, E. (2015). Enhanced levels of chemokines and their receptors in the colon of microscopic colitis patients indicate mixed immune cell recruitment. Mediators of Inflammation.
Daferera, N. , Kumawat, A. K. , Hultgren-Hörnquist, E. , Ignatova, S. , Ström, M. & Münch, A. (2015). Fecal stream diversion and mucosal cytokine levels in collagenous colitis: A case report. World Journal of Gastroenterology, 21 (19), 6065-6071.
Sundin, J. , Rangel, I. , Kumawat, A. K. , Hultgren-Hörnquist, E. & Brummer, R. J. (2014). Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients. Scandinavian Journal of Gastroenterology, 49 (9), 1068-1075.
Günaltay, S. , Nyhlin, N. , Kumawat, A. K. , Tysk, C. , Bohr, J. , Hultgren, O. & Hultgren-Hörnquist, E. (2014). Differential expression of interleukin-1/Toll-like receptor signaling regulators in microscopic and ulcerative colitis. World Journal of Gastroenterology, 20 (34), 12249-12259.
Gunaltay, S. , Ghiboub, M. , Hultgren, O. & Hultgren-Hörnquist, E. (2014). The role of IL-37 on cytokine responses downstream of TLR4 and TLR5 signalling in intestinal epithelial cells. Immunology, 143, 94-95.
Rangel, I. , Ganda-Mall, J. , Sjöberg, F. , Willen, R. & Hultgren-Hörnquist, E. (2013). Alterations in gut microbiota composition in tissues and feces of G alpha i2(-/-) mice with colitis in parallel with enhanced cytokine secretion. Immunology, 140, 168-169.
Kumawat, A. , Tysk, C. , Bohr, J. , Hultgren, O. & Hultgren-Hörnquist, E. (2013). An in vitro model for analysis of the impact of the colonic milieu in collagenous colitis patients on peripheral T lymphocyte activation and differentiation. Immunology, 140, 168-168.
Gunaltay, S. , Nyhlin, N. , Kumawat, A. , Tysk, C. , Bohr, J. , Hultgren, O. & Hultgren-Hörnquist, E. (2013). IL-1/TLR signaling inhibitors in microscopic and ulcerative colitis: Immunopathogenic markers of active disease and remission. Immunology, 140, 167-167.
Göranzon, C. , Kumawat, A. K. , Hultgren-Hörnqvist, E. , Tysk, C. , Eriksson, S. , Bohr, J. & Nyhlin, N. (2013). Immunohistochemical characterization of lymphocytes in microscopic colitis. Journal of Crohn's and Colitis, 7 (10), e434-e442.
Gunaltay, S. , Nyhlin, N. , Kumawat, A. , Bohr, J. , Tysk, C. , Hultgren, O. & Hultgren-Hörnquist, E. (2013). Increased expression of T cell recruiting chemokines in the colonic mucosa of microscopic colitis patients. Immunology, 140, 135-135.
Götlind, Y. Y. , Fritsch Fredin, M. , Kumawat, A. K. , Strid, H. , Willén, R. , Rangel, I. , Bland, P. W. & Hultgren Hörnquist, E. (2013). Interplay between Th1 and Th17 effector T cell pathways in the pathogenesis of spontaneous colitis and colon cancer in the Gai2-deficient mouse. International Immunology, 25 (1), 35-44.
Kumawat, A. K. , Strid, H. , Tysk, C. , Bohr, J. & Hultgren-Hörnquist, E. (2013). Microscopic colitis patients demonstrate a mixed Th17/Tc17 and Th1/Tc1 mucosal cytokine profile. Molecular Immunology, 55 (3-4), 355-364.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2013). Microscopic colitis patients have increased frequencies of Ki67+proliferating and CD45RO+ active/memory CD8+ and CD4+8mucosal T cells. Journal of Crohn's & Colitis, 7 (9), 694-705.
Fant, F. , Tina, E. , Sandblom, D. , Andersson, S. , Magnuson, A. , Hultgren-Hörnquist, E. , Axelsson, K. & Gupta, A. (2013). Thoracic epidural analgesia inhibits the neuro-hormonal but not the acute inflammatory stress response after radical retropubic prostatectomy. British Journal of Anaesthesia, 110 (5), 747-757.
Sundin, J. , Brummer, R. , Hultgren Hörnquist, E. & Rangel, I. (2012). Increased number of double positive CD3+ CD8+ CD4+ lamina propria T lymphocyte in gut mucosa of post infectious IBS patients compared to healthy controls. Neurogastroenterology and Motility, 24 (Suppl. 2), 104-105.
Strid, H. , Kumawat, A. K. , Tysk, C. , Hultgren Hörnquist, E. & Bohr, J. (2011). Altered gene expression of IL-6 and rennin in colonic biopsies from collagenous colitis and ulcerative colitis compared to healthy controls. Gut, 60 (Suppl. 3), A317.
Gotlind, Y. C. , Raghavan, S. , Bland, P. W. & Hultgren Hörnquist, E. (2011). CD4(+)FoxP3(+) Regulatory T Cells from G alpha i2(-/-) Mice Are Functionally Active In Vitro, but Do Not Prevent Colitis. PLoS ONE, 6 (9), e25073.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Nyhlin, N. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2011). Collagenous colitis patients demonstrate a Th1/CTL-associated gene expression profile with increased frequencies of Ki67+ proliferating and CD45RO+ activated/memory CD8+ and CD4+8+ mucosal T cells. Gut, 60 (Suppl. 3), A318.
Göranzon, C. , Hultgren Hörnquist, E. , Kumawat, A. K. , Halfvarson, J. , Tysk, C. , Eriksson, J. , Bohr, J. & Nyhlin, N. (2011). Immunohistokemisk karakterisering av lymfocyter vid microscopisk kolit. Gastrokuriren, 16 (29), PO16-PO16.
Kumawat, A. , Elgbratt, K. , Bohr, J. , Tysk, C. & Hultgren Hörnquist, E. (2011). Increased frequencies of Ki67+ proliferating and CD45RO+ memory CD8+ and CD4+8+ T lymphocytes in the intestinal mucosa of collagenous colitis patients. Scandinavian Journal of Immunology, 73 (4), 374-374.
Kumawat, A. , Götlind, Y. , Fritsch Fredin, M. , Willén, R. , Chazot, P. , Strid, H. & Hultgren Hörnquist, E. (2011). Modulation of histamine 4 receptor mRNA and protein expression in Gai2-deficient mice during colitis progression. Scandinavian Journal of Immunology, 73 (4), 373-373.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Nyhlin, N. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2011). Ökat uttryck av Th1/CTL-associerade gener samt högre frekvens CD8+ och CD4+8+, Ki67+ prolifererande, CD45RO+ aktiverade/minnes-T-celler i tarmslemhinnan hos patienter med kollagen kolit. Gastrokuriren, 16.
Kumawat, A. K. , Götlind, Y. Y. , Fredin, M. F. , Willén, R. , Strid, H. & Hultgren-Hörnquist, E. (2010). Expression patterns of histamine receptors in the g alpha i2-deficient mouse model of colitis. Inflammation Research, 59, S358-S359.
Kumawat, A. K. , Götlind, Y. Y. , Fritsch Fredin, M. , Willén, R. , Strid, H. & Hultgren Hörnquist, E. (2010). Expression patterns of histamine receptors in the Gai2-deficient mouse model of colitis. Inflammation Research, 59 (Suppl 4), S358-S359.
Berglund, M. , Melgar, S. , Kobayashi, K. S. , Flavell, R. A. , Hultgren Hörnquist, E. & Hultgren, O. H. (2010). IL-1 receptor-associated kinase M downregulates DSS-induced colitis. Inflammatory Bowel Diseases, 16 (10), 1778-1786.
Lindberg, E. , Andersson, B. , Hultgren Hörnquist, E. & Magnusson, Y. (2010). Impaired activation of IFN-gamma+CD4+ T cells in peripheral blood of patients with dilated cardiomyopathy. Cellular Immunology, 263 (2), 224-229.
Elgbratt, K. , Kurlberg, G. , Hahn-Zohric, M. & Hultgren-Hörnquist, E. (2010). Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients. Clinical and Experimental Immunology, 162 (2), 325-336.
Berglund, M. , Thomas, J. A. , Fritsch Fredin, M. , Melgar, S. , Hultgren-Hörnquist, E. & Hultgren, O. H. (2009). Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis. Cellular Immunology, 259 (1), 27-32.
Fritsch Fredin, M. , Hultin, L. , Hyberg, G. , Rehnström, E. , Hultgren Hörnquist, E. , Melgar, S. & Jansson, L. (2008). Predicting and monitoring colitis development in mice by micro-computed tomography. Inflammatory Bowel Diseases, 14 (4), 491-499.
Fritsch Fredin, M. , Vidal, A. , Utkovic, H. , Götlind, Y. , Willén, R. , Jansson, L. , Hultgren Hörnquist, E. & Melgar, S. (2008). The application and relevance of ex vivo culture systems for assessment of IBD treatment in murine models of colitis. Pharmacological Research, 58 (3-4), 222-231.

Artiklar, forskningsöversikter

Bohr, J. , Wickbom, A. , Hegedus, A. , Nyhlin, N. , Hultgren-Hörnquist, E. & Tysk, C. (2014). Diagnosis and management of microscopic colitis: Current perspectives. Clinical and Experimental Gastroenterology, 7, 273-284.
Jansson, A. , Pernestig, A. , Nilsson, P. , Jirstrand, M. & Hultgren Hörnquist, E. (2013). Toward quantifying the thymic dysfunction state in mouse models of inflammatory bowel disease. Inflammatory Bowel Diseases, 19 (4), 881-888.

Konferensbidrag

Strid, H. , Kumawat, A. , Tysk, C. , Hultgren Hörnquist, E. & Bohr, J. (2012). Genuttrycket för Renin och IL-6 i kolonmucosan är förändrad vid kollagen kolit. Konferensbidrag vid Svenska Gastrodagarna, Malmö, 8-11 Maj, 2012.
Sundin, J. , Kumawat, A. K. , Rangel, I. , Brummer, R. & Hultgren Hörnquist, E. (2012). Karakterisering av T-lymfocyter från tarmmukosan hos patienter med postinfektiös IBS. Konferensbidrag vid Svenska Gastrodagarna, Malmö 8-11 Maj 2012.
Kumawat, A. K. , Strid, H. , Tysk, C. , Bohr, J. & Hultgren-Hörnquist, E. (2012). Patienter med mikroskopisk kolit har blandad Th1/Th17 samt CTL-associerad cytokinprofil. Konferensbidrag vid Svenska Gastrodagarna, Malmö, 8-11 Maj, 2012.
Hultgren Hörnquist, E. (2012). The mucosal immune system in microscopic colitis. I: S. Miehlke, A. Münich, Microscopic colitis. Konferensbidrag vid Falk Workshop, Basel, Schweiz, May 3-5, 2012 (ss. 33-39). Basel: S. Karger.
Hultgren Hörnquist, E. , Nilsson, K. , Andersson, T. , Tidefelt, U. & Lidskog, M. (2011). Building a PBL-based integrated curriculum for a new medical school in Sweden. Konferensbidrag vid Celebrating the Past and Embracing the Future: Evolution and Innovation in Problem-based Larning, Conference, Grange-Over-Sands, UK, March 30-31, 2011.
Kumawat, A. K. , Strid, H. , Elgbratt, K. , Nyhlin, N. , Tysk, C. , Bohr, J. & Hultgren Hörnquist, E. (2011). Collagenous colitis patients demonstrate a Th1/CTL-associated gene expression profile with increased frequencies of Ki67+ proliferating and CD45RO+ activated/ memory CD8+ and CD4+8+ mucosal T cells. Konferensbidrag vid International Congress of Mucosal Immunology, Paris, July 5-9, 2011.
Chiu Götlind, Y. Y. , Raghavan, S. , Bland, P. W. & Hultgren Hörnquist, E. (2010). CD4+FoxP3+ regulatory T cellsare functionally active in the Gαi2−/− mouse, but do not prevent thedevelopment of colitis. Konferensbidrag vid 14th International Congress of Immunology. Kobe, Japan, August, 2010.
Rangel, I. , Ganda-Mall, J. , Elgbratt, K. & Hultgren Hörnquist, E. (2010). Development of colitis in Gai2-deficient mice is associated with profound changes in the microbiota. Konferensbidrag vid EMIG2010, European Mucosal Immunology Group meeting, Amsterdam, September 29 - October 2, 2010.
Göranzon, C. , Hultgren Hörnquist, E. , Kumawat, A. K. , Halfvarson, J. , Tysk, C. , Eriksson, S. , Bohr, J. & Nyhlin, N. (2010). Immunohistochemical characterization of lymphocytes in microscopic colitis. Konferensbidrag vid 18th United European Gastroenterology Week, Barcelona, Oct, 2010.

Manuskript

Fant, F. , Tina, E. , Sandblom, D. , Andersson, S. , Magnuson, A. , Hultgren-Hörnquist, E. & Gupta, A. Early perioperative immunological effects of anesthesia and analgesia in patients undergoing prostate cancer surgery.
Günaltay, S. , Repsilber, D. , Helenius, G. , Nyhlin, N. , Bohr, J. & Hultgren-Hörnquist, E. Oligoclonal T cell receptor repertoire in colonic biopsies of microscopic and ulcerative colitis patients.
Günaltay, S. , Ghiboub, M. , Hultgren, O. & Hultgren-Hörnquist, E. Reduced Il-37 production increases the spontaneous chemokine expressions in colon epithelial cells.
Fant, F. , Tina, E. , Hultgren-Hörnquist, E. , Magnuson, A. , Sandblom, D. , Andersson, S. , Axelsson, K. & Gupta, A. Thoracic epidural analgesia inhibits the neuro-hormonal but not the acute inflammatory stress response following radical retropubic prostatectomy.