Knut FälkerTitle: Researcher School/office: School of Medical Sciences
Phone: +46 19 301254
About Knut Fälker
Knut Fälker defended his doctoral thesis entitled “Activation and regulation of the extracellular signal-regulated kinase 2 (ERK2) in human platelets’, conducted at the Department of Pharmacology and Toxicology, Medical Faculty of the Martin-Luther-University Halle-Wittenberg, Halle an der Saale, Germany, in the year 2005.
Thereafter, he worked as a postdoctoral fellow and researcher in the Disease Group Thrombosis & Angiogenesis, Section Molecular Biology and Biochemistry, at Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany, and the Cardiovascular Inflammation Research Centre (CIRC) at the Faculty of Health Sciences, Linköping University, Sweden.
In 2013, Knut joined Örebro University’s School of Medical Sciences as a researcher affiliated with the Cardiovascular Research Centre (CVRC).
Research and associated assignments
Knut Fälker’s research is focused on understanding the physiology of human platelets (also designated thrombocytes.) Platelets play a pivotal role in physiological haemostasis, which is the human body's instant response to blood vessel injury in order to stop bleeding.
In contrast, under pathophysiological conditions, such as atherosclerosis, inappropriate platelet activation and platelet-plug formation can cause vascular occlusions resulting in myocardial infarctions or stroke, which are, according to the World Health Organization (WHO), the worldwide leading causes for death.
Hence, Knut’s research emphasizes on the investigation of diverse platelet receptors and connected signalling pathways involved in, or contribute to, the activation and regulation of human platelets; and how these mechanisms may contribute to both physiological hemostasis as well as to pathologic thrombus formation. Since human platelets, due to their non-nucleated nature, cannot be genetically modified, his main challenge often lies in the development of experimental strategies and the use of pharmacological tools to specifically modulate platelet signalling pathways and functional responses.
As a renowned member of the "platelet community", Knut is frequently invited and serves as reviewer for scientific journals, such as Haematologica, Thrombosis & Haemostasis, or FEBS letters, as well as for committees such as the UK research council or the organizers of the European Platelet Meeting.
Teaching and institutional assignments
Knut Fälker is the current course-coordinator and examiner of the third semester of Örebro University's medical program, the latter in which he also serves as an experienced PBL-group tutor and project-supervisor.
Knut is further a steering member of the council for the international Master’s programme Experimental Medicine, as well as course-coordinator and examiner in the profile Cardiovascular Biomedicine, the latter in which he is vividly involved as lecturer and as supervising tutor for practical trainings and Master’s projects. Further, Knut initiated and substantially develpoped the programme’s quite unique approach to personally counsel and support students in their professional development and networking.
For the School of Medical Sciences’ open seminar series "MV Science Forum", Knut has been designated as the overall coordinator as well as representative for the Cardiovascular Research Centre (CVRC), and frequently arranges for highly appreciated talks from national and international speakers.