Samira Salihovic
Title: Associate Senior Lecturer School/office: School of Medical Sciences
Email:
Phone: +46 19 303226
Room: B3122, C2208
Research Subject
Research environments
About Samira Salihovic
Samira Salihovic is a researcher in chemistry. She did her doctoral studies at Man Technology and Environment (MTM) Research Centre at Örebro University and graduated in 2013. Following postdoctoral postitions at the Molecular Epidemiology Unit at Uppsala University (2013-2018) and Department of Toxic Substances Control, California Environmental Protection Agency (CAL-EPA) in Berkely (2016) she rejoined Örebro University as a part of Inflammation Response and Infection Susceptibility Centre (iRiSC) in November 2018. Her main interests and activities are focused on environmental exposure science, environmental epidemiology, and metabolomics in large population based studies. She is currently expanding her research within the field of immunometabolism.
Research Projects
Research Projects
Research Teams
Research Teams
Publications
Publications
Articles in journals |
Conference papers |
Doctoral theses, comprehensive summaries |
Manuscripts |
Articles in journals
Sinisalu, L. , Sen, P. , Salihovic, S. , Virtanen, S. M. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2020). Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease. Environmental Research, 188.
Lin, Y. , Salihovic, S. , Fall, T. , Hammar, U. , Ingelsson, E. , Ärnlöv, J. , Lind, L.
& Sundström, J. (2020). Global Plasma Metabolomics to Identify Potential Biomarkers of Blood Pressure Progression. Arteriosclerosis, Thrombosis and Vascular Biology, 40 (8), e227-e237.
Fart, F. , Salihovic, S. , McGlinchey, A. J. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T.
& Schoultz, I. (2020). Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis. Journal of Crohn's & Colitis, 14 (Suppl. 1), S138-S139.
Salihovic, S. , Dickens, A. M. , Schoultz, I. , Fart, F. , Sinisalu, L. , Lindeman, T. , Halfvarson, J. , Oresic, M.
& et al.
(2020). Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 412 (10), 2251-2259.
Lind, P. M. , Salihovic, S. , Stubleski, J. , Kärrman, A.
& Lind, L. (2019). Association of Exposure to Persistent Organic Pollutants With Mortality Risk: An Analysis of Data From the Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS) Study. JAMA network open, 2 (4).
Jayasinghe, S. , Lind, L. , Salihovic, S. , Larsson, A.
& Lind, P. M. (2019). DDT and its metabolites could contribute to the aetiology of chronic kidney disease of unknown aetiology (CKDu) and more studies are a priority. Science of the Total Environment, 649, 1638-1639.
Salihovic, S. , Fall, T. , Ganna, A. , Broeckling, C. D. , Prenni, J. E. , Hyötyläinen, T. , Kärrman, A. , Lind, P. M.
& et al.
(2019). Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances. Journal of Exposure Science and Environmental Epidemiology, 29 (2), 196-205.
Stubleski, J. , Kukucka, P. , Salihovic, S. , Lind, P. M. , Lind, L.
& Kärrman, A. (2018). A method for analysis of marker persistent organic pollutants in low-volume plasma and serum samples using 96-well plate solid phase extraction. Journal of Chromatography A, 1546, 18-27.
Salihovic, S. , Stubleski, J. , Kärrman, A. , Larsson, A. , Fall, T. , Lind, L.
& Lind, P. M. (2018). Changes in markers of liver function in relation to changes in perfluoroalkyl substances: A longitudinal study. Environment International, 117, 196-203.
Lind, P. M. , Salihovic, S. , Stubleski, J. , Kärrman, A.
& Lind, L. (2018). Changes in plasma levels of perfluoroalkyl substances (PFASs) are related to increase in carotid intima-media thickness over 10 years - a longitudinal study. Environmental health, 17.
Nowak, C. , Hetty, S. , Salihovic, S. , Castillejo-Lopez, C. , Ganna, A. , Cook, N. L. , Broeckling, C. D. , Prenni, J. E.
& et al.
(2018). Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance. Scientific Reports, 8 (1).
Lind, P. M. , Salihovic, S.
& Lind, L. (2018). High plasma organochlorine pesticide levels are related to increased biological age as calculated by DNA methylation analysis. Environment International, 113, 109-113.
Jayasinghe, S. , Lind, L. , Salihovic, S. , Larsson, A.
& Lind, P. M. (2018). High serum levels of p,p'-DDE are associated with an accelerated decline in GFR during 10 years follow-up. Science of the Total Environment, 644, 371-374.
Stubleski, J. , Lind, L. , Salihovic, S. , Lind, P. M.
& Kärrman, A. (2018). Longitudinal changes in persistent organic pollutants (POPs) from 2001 to 2009 in a sample of elderly Swedish men and women. Environmental Research, 165, 193-200.
La Merrill, M. A. , Lind, P. M. , Salihovic, S. , van Bavel, B.
& Lind, L. (2018). The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity. Environmental Research, 160, 541-546.
Lind, P. M. , Salihovic, S. , van Bavel, B.
& Lind, L. (2017). Circulating levels of perfluoroalkyl substances (PFASs) and carotid artery atherosclerosis. Environmental Research, 152, 157-164.
Lind, L. , Ng, E. , Ingelsson, E. , Lindgren, C. , Salihovic, S. , van Bavel, B. , Mahajan, A. , Lampa, E.
& et al.
(2017). Genetic and methylation variation in the CYP2B6 gene is related to circulating p,p '-dde levels in a population-based sample. Environment International, 98, 212-218.
Park, W. H. , Kang, S. , Lee, H. K. , Salihovic, S. , van Bavel, B. , Lind, P. M. , Pak, Y. K.
& Lind, L. (2017). Relationships between serum-induced AhR bioactivity or mitochondrial inhibition and circulating polychlorinated biphenyls (PCBs). Scientific Reports, 7.
Lind, M. , Salihovic, S. , Stubleski, J. , Kärrman, A. , van Bavel, B.
& Lind, L. (2017). The changes in plasma levels of perfluoroalkyl substances (PFASs) are related to the increase in carotid intima-media thickness over 10 years. Atherosclerosis, 263, E18-E18.
Stubleski, J. , Salihovic, S. , Lind, P. M. , Lind, L. , Dunder, L. , McCleaf, P. , Eurén, K. , Ahrens, L.
& et al.
(2017). The effect of drinking water contaminated with perfluoroalkyl substances on a 10-year longitudinal trend of plasma levels in an elderly Uppsala cohort. Environmental Research, 159, 95-102.
Lee, D. , Lind, P. M. , Jacobs, D. R. , Salihovic, S. , van Bavel, B.
& Lind, L. (2016). Association between background exposure to organochlorine pesticides and the risk of cognitive impairment: A prospective study that accounts for weight change. Environment International, 89-90, 179-184.
Stubleski, J. , Salihovic, S. , Lind, L. , Lind, P. M. , van Bavel, B.
& Kärrman, A. (2016). Changes in serum levels of perfluoroalkyl substances during a 10-year follow-up period in a large population-based cohort. Environment International, 95, 86-92.
Sjögren, P. , Montse, R. , Lampa, E. , Salihovic, S. , van Bavel, B. , Lind, L.
& Lind, P. M. (2016). Circulating levels of perfluoroalkyl substances are associated with dietary patterns: A cross sectional study in elderly Swedish men and women. Environmental Research, 150, 59-65.
Salihovic, S. , Ganna, A. , Fall, T. , Broeckling, C. D. , Prenni, J. E. , van Bavel, B. , Lind, P. M. , Ingelsson, E.
& et al.
(2016). The metabolic fingerprint of p,p'-DDE and HCB exposure in humans. Environment International, 88, 60-66.
Ax, E. , Lampa, E. , Lind, L. , Salihovic, S. , van Bavel, B. , Cederholm, T. , Sjögren, P.
& Lind, P. M. (2015). Circulating levels of environmental contaminants are associated with dietary patterns in older adults. Environment International, 75, 93-102.
Lind, L. , Salihovic, S. , Van Bavel, B.
& Lind, M. (2015). Circulating levels of perfluorinated compounds and left ventricular geometry. Toxicology Letters, 238 (2), S93-S93.
Lind, M. , Salihovic, S. , Larsson, A. , van Bavel, B.
& Lind, L. (2015). Circulating levels of perfluoroalkyl substances and biomarkers of liver function in a large population based sample of elderly men and women from Sweden. Toxicology Letters, 238 (2), S91-S91.
Helmfrid, I. , Salihovic, S. , van Bavel, B. , Wingren, G.
& Berglund, M. (2015). Exposure and body burden of polychlorinated biphenyls (PCB) and metals in a historically contaminated community. Environment International, 76, 41-48.
Ng, E. , Salihovic, S. , Lind, P. M. , Mahajan, A. , Syvänen, A. , Axelsson, T. , Ingelsson, E. , Lindgren, C. M.
& et al.
(2015). Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample. Environmental Research, 140, 95-101.
Salihovic, S. , Kärrman, A. , Lind, L. , Lind, P. M. , Lindström, G.
& van Bavel, B. (2015). Perfluoroalkyl substances (PFAS) including structural PFOS isomers in plasma from elderly men and women from Sweden: Results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). Environment International, 82 (Sept 2015), 21-27.
Lind, L. , Zethelius, B. , Salihovic, S. , van Bavel, B.
& Lind, P. M. (2014). Circulating levels of perfluoroalkyl substances and prevalent diabetes in the elderly. Diabetologia, 57 (3), 473-479.
Lind, P. M. , Penell, J. , Salihovic, S. , van Bavel, B.
& Lind, L. (2014). Circulating levels of p,p '-DDE are related to prevalent hypertension in the elderly. Environmental Research, 129, 27-31.
Lee, D. , Lind, L. , Jacobs, D. R. J. , Salihovic, S. , van Bavel, B.
& Lind, P. M. (2014). Does Mortality Risk of Cigarette Smoking Depend on Serum Concentrations of Persistent Organic Pollutants?: Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) Study. PLoS ONE, 9 (5), e95937.
Lind, L. , Penell, J. , Syvänen, A. , Axelsson, T. , Ingelsson, E. , Morris, A. P. , Lindgren, C. , Salihovic, S.
& et al.
(2014). Genetic variation in the CYP1A1 gene is related to circulating PCB118 levels in a population-based sample. Environmental Research, 133, 135-140.
Penell, J. , Lind, L. , Fall, T. , Syvanen, A. , Axelsson, T. , Lundmark, P. , Morris, A. P. , Lindgren, C.
& et al.
(2014). Genetic variation in the CYP2B6 Gene is related to circulating 2,2 ',4,4 '-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study. Environmental health, 13, 34.
Kumar, J. , Lind, P. M. , Salihovic, S. , van Bavel, B. , Lind, L.
& Ingelsson, E. (2014). Influence of persistent organic pollutants on oxidative stress in population-based samples. Chemosphere, 114, 303-309.
Kumar, J. , Lind, P. M. , Salihovic, S. , van Bavel, B. , Ekdahl, K. N. , Nilsson, B. , Lind, L.
& Ingelsson, E. (2014). Influence of persistent organic pollutants on the complement system in a population-based human sample. Environment International, 71, 94-100.
Kumar, J. , Lind, M. , Salihovic, S. , van Bavel, B. , Ingelsson, E.
& Lind, L. (2014). Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort. Journal of Environmental Health Perspectives, 122 (9), 977-983.
Kumar, J. , Lind, L. , Salihovic, S. , van Bavel, B. , Ingelsson, E.
& Lind, P. M. (2014). Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women. Environmental Research, 134, 251-256.
Penell, J. , Lind, L. , Salihovic, S. , van Bavel, B.
& Lind, R. M. (2014). Persistent organic pollutants are related to the change in circulating lipid levels during a 5 year follow-up. Environmental Research, 134, 190-197.
Ljunggren, S. A. , Helmfrid, I. , Salihovic, S. , van Bavel, B. , Wingren, G. , Lindahl, M.
& Karlsson, H. (2014). Persistent organic pollutants distribution in lipoprotein fractions in relation to cardiovascular disease and cancer. Environment International, 65, 93-99.
Salihovic, S. , Kärrman, A. , Lindström, G. , Lind, P. M. , Lind, L.
& van Bavel, B. (2013). A rapid method for the determination of perfluoroalkyl substances including structural isomers of perfluorooctane sulfonic acid in human serum using 96-well plates and column-switching ultra-high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography A, 1305, 164-170.
Lind, P. M. , Riserus, U. , Salihovic, S. , van Bavel, B.
& Lind, L. (2013). An environmental wide association study (EWAS) approach to the metabolic syndrome. Environment International, 55, 1-8.
Geng, D. , Ericson Jogsten, I. , Salihovic, S. , Dunstan, J. , Ruzzin, J. , Rémi, R.
& van Bavel, B. (2013). Atmospheric pressure gas chromatography (APGC) coupled to triple quadrupole mass spectrometry (MS/MS) for the quantitative analysis of pesticides and PCBs regulated by the Stockholm Convention. Organohalogen Compounds, 75.
Lind, P. M. , Lee, D. , Jacobs, D. R. , Salihovic, S. , van Bavel, B. , Wolff, M. S.
& Lind, L. (2013). Circulating levels of persistent organic pollutants are related to retrospective assessment of life-time weight change. Chemosphere, 90 (3), 998-1004.
Roos, V. , Rönn, M. , Salihovic, S. , Lind, L. , van Bavel, B. , Kullberg, J. , Johansson, L. , Ahlström, H.
& et al.
(2013). Circulating Levels of Persistent Organic Pollutants in Relation to Visceral and Subcutaneous Adipose Tissue by Abdominal MRI. Obesity, 21 (2), 413-418.
Sjöberg Lind, Y. , Lind, P. M. , Salihovic, S. , van Bavel, B.
& Lind, L. (2013). Circulating levels of persistent organic pollutants (POPs) are associated with left ventricular systolic and diastolic dysfunction in the elderly. Environmental Research, 123, 39-45.
Lind, L. , Penell, J. , Luttropp, K. , Nordfors, L. , Syvänen, A. , Axelsson, T. , Salihovic, S. , van Bavel, B.
& et al.
(2013). Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population. Environment International, 59, 456-461.
Lind, Y. S. , Lind, L. , Salihovic, S. , van Bavel, B.
& Lind, P. M. (2013). Persistent organic pollutants and abnormal geometry of the left ventricle in the elderly. Journal of Hypertension, 31 (8), 1547-1553.
Salihovic, S. , Nilsson, H. , Hagberg, J.
& Lindström, G. (2013). Trends in the analysis of persistent organic pollutants (POPs) in human blood. TrAC. Trends in analytical chemistry, 46, 129-138.
Salihovic, S. , Mattioli, L. , Lindström, G. , Lind, L. , Lind, P. M.
& van Bavel, B. (2012). A rapid method for screening of the Stockholm Convention POPs in small amounts of human plasma using SPE and HRGC/HRMS. Chemosphere, 86 (7), 747-753.
Lind, L. , Salihovic, S. , van Bavel, B. , Riserius, U.
& Lind, P. M. (2012). An environmental and life-style wide association study (ELWAS) approach. Toxicology Letters, 211 (Supplement), S81-S81.
Lampa, E. , Lind, L. , Hermansson, A. B. , Salihovic, S. , van Bavel, B.
& Lind, P. M. (2012). An investigation of the co-variation in circulating levels of a large number of environmental contaminants. Journal of Exposure Science and Environmental Epidemiology, 22 (5), 476-482.
Lee, D. , Lind, L. , Jacobs, D. R. J. , Salihovic, S. , van Bavel, B.
& Lind, P. M. (2012). Associations of persistent organic pollutants with abdominal obesity in the elderly: The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Environment International, 40, 170-178.
Lee, D. , Lind, P. M. , Jacobs, D. R. J. , Salihovic, S. , van Bavel, B.
& Lind, L. (2012). Background exposure to persistent organic pollutants predicts stroke in the elderly. Environment International, 47, 115-120.
Ax, E. , Salihovic, S. , Lind, P. M. , van Bavel, B. , Lind, L. , Lampa, E.
& Sjögren, P. (2012). Circulating levels of environmental contaminants are associated with dietary pattern. Toxicology Letters, 211 (Supplement), S101-S101.
Salihovic, S. , Lampa, E. , Lindström, G. , Lind, L. , Lind, P. M.
& van Bavel, B. (2012). Circulating levels of Persistent Organic Pollutants (POPs) among elderly men and women from Sweden: results from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS). Environment International, 44, 59-67.
Lind, P. M. , van Bavel, B. , Salihovic, S.
& Lind, L. (2012). Circulating Levels of Persistent Organic Pollutants (POPs) and Carotid Atherosclerosis in the Elderly. Journal of Environmental Health Perspectives, 120 (1), 38-43.
Lind, P. M. , Salihovic, S. , van Bavel, B.
& Lind, L. (2012). Circulating levels of pp-DDE and hypertension. Toxicology Letters, 211 (Supplement), S83.
Lind, L. , Nordfors, L. , Luttrop, K. , Syvänen, A. , Salihovic, S. , van Bavel, B.
& Lind, P. M. (2012). DNA methylation and persistent organic pollutants. Toxicology Letters, 211 (Supplement), S82.
Lampa, E. , Lind, L. , Salihovic, S. , van Bavel, B.
& Lind, P. M. (2012). Mixtures of environmental contaminants and the metabolic syndrome. Toxicology Letters, 211 (Supplement), S35.
Lind, M. , Roos, V. , Rönn, M. , Salihovic, S. , van Bavel, B. , Ahlström, H. , Johansson, L. , Kullberg, J.
& et al.
(2012). Persistent organic pollutants and adipose tissue distribution. Toxicology Letters, 211 (Supplement), S82.
Sjöberg Lind, Y. , Lind, P. M. , Salihovic, S.
& van Bavel, B. (2012). POPs are associated with left ventricular systolic and diastolic dysfunction. Toxicology Letters, 211 (Supplement), S83.
Rönn, M. , Lind, L. , van Bavel, B. , Salihovic, S. , Michaelsson, K.
& Lind, P. M. (2011). Circulating levels of persistent organic pollutants associate in divergent ways to fat mass measured by DXA in humans. Chemosphere, 85 (3), 335-343.
Ax, E. , Sjögren, P. , Lind, P. M. , Lampa, E. , Salihovic, S. , van Bavel, B.
& Lind, L. (2011). Dietary pattern affects blood levels of environmental pollutants in elderly Swedish men and women. Annals of Nutrition and Metabolism, 58 (Suppl. 3), 59-60.
Lee, D. , Lind, P. M. , Jacobs, D. R. J. , Salihovic, S. , van Bavel, B.
& Lind, L. (2011). Polychlorinated Biphenyls and Organochlorine Pesticides in Plasma Predict Development of Type 2 Diabetes in the Elderly. Diabetes Care, 34 (8), 1778-1784.
Haug, L. S. , Salihovic, S. , Ericson Jogsten, I. , Thomsen, C. , van Bavel, B. , Lindström, G.
& Becher, G. (2010). Levels in food and beverages and daily intake of perfluorinated compounds in Norway. Chemosphere, 80 (10), 1137-1143.
Conference papers
van Bavel, B. , Hagberg, J. , Salihovic, S. , Li, S.
& Xu, M. (2011). Development of a MEPs based clean up for the analysis of dioxinad and Stockholm Convention POPs.
In:
Organohalogen Compounds. Paper presented at Dioxin 2011, 31st International symposium on halogenated persistent organic pollutants - POPs’ Science in the Heart of Europe Brussels, Belgium, 21-25 August, 2011 (pp. 807-809).
Doctoral theses, comprehensive summaries
Salihovic, S. (2013). Development and application of high-throughput methods for analysis of persistent organic pollutants in human blood.
(Doctoral dissertation).
(Comprehensive summary)
Örebro: Örebro universitet.
Manuscripts
Stubleski, J. , Kukucka, P. , Salihovic, S.
& Kärrman, A. A new method for analysis of marker POPs in low-volume plasma and serum samples using 96-well plate solid phase extraction.
Salihovic, S. , Kärrman, A. , Lindström, G. , Lind, P. M. , Lind, L.
& van Bavel, B. A rapid method for analysis of PFAS including structural PFOS isomers in human serum using 96-well plate column-switching UPLC-S/MS.
Stubleski, J. , Lind, L. , Salihovic, S. , Lind, M. P.
& Kärrman, A. Longitudinal changes in persistent organic pollutants (POPs) over 5 years in a sample of elderly men and women.