Articles in journals |
Articles, reviews/surveys |
Chapters in books |
Manuscripts |
Articles in journals
Blanc, M. , Alfonso, S. , Begout, M. , Barrachina, C. , Hyötyläinen, T. , Keiter, S. H.
& Cousin, X. (2021).
An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. Science of the Total Environment, 754.
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Dickens, A. M. , Sen, P. , Kempton, M. J. , Barrantes-Vidal, N. , Iyegbe, C. , Nordentoft, M. , Pollak, T. , Riecher-Rössler, A.
& et al.
(2021).
Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biological Psychiatry, 89 (3), 288-297.
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Castro Alves, V. , Kalbina, I. , Nilsen, A. , Mats, A. , Rosenqvist, E. , Jansen, M. A. K. , Qian, M. , Öström, Å.
& et al.
(2021).
Integration of non-target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality: A case study using dill (Anethum graveolens). Food Chemistry, 344.
Information via DOIFull text in DiVA
Salonurmi, T. , Nabil, H. , Ronkainen, J. , Hyötyläinen, T. , Hautajärvi, H. , Savolainen, M. J. , Tolonen, A. , Oresic, M.
& et al.
(2020).
4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.. Frontiers in Pharmacology, 11.
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Lamichhane, S. , Dickens, A. M. , Sen, P. , Laurikainen, H. , Borgan, F. , Suvisaari, J. , Hyötyläinen, T. , Howes, O.
& et al.
(2020).
Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis. Schizophrenia Bulletin.
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Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , de Vos, W. M.
& et al.
(2020).
Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome. Beneficial Microbes, 1-14.
Information via DOI
Sinisalu, L. , Sen, P. , Salihovic, S. , Virtanen, S. M. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2020).
Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease. Environmental Research, 188.
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Djekic, D. , Shi, L. , Calais, F. , Carlsson, F. , Landberg, R. , Hyötyläinen, T.
& Fröbert, O. (2020).
Effects of a Lacto-Ovo-Vegetarian Diet on the Plasma Lipidome and Its Association with Atherosclerotic Burden in Patients with Coronary Artery Disease-A Randomized, Open-Label, Cross-over Study. Nutrients, 12 (11).
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Luukkonen, P. K. , Tukiainen, T. , Juuti, A. , Sammalkorpi, H. , Haridas, P. A. N. , Niemelä, O. , Arola, J. , Orho-Melander, M.
& et al.
(2020).
Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight, 5 (5).
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Thomas, I. , Dickens, A. M. , Posti, J. P. , Mohammadian, M. , Ledig, C. , Takala, R. S. K. , Hyötyläinen, T. , Tenovuo, O.
& et al.
(2020).
Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury. International Journal of Molecular Sciences, 21 (4).
Information via DOIFull text in DiVA
Dickens, A. M. , Borgan, F. , Laurikainen, H. , Lamichhane, S. , Marques, T. , Rönkkö, T. , Veronese, M. , Lindeman, T.
& et al.
(2020).
Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis. NPJ schizophrenia, 6 (1).
Information via DOI
Luukkonen, P. K. , Juuti, A. , Sammalkorpi, H. , Penttilä, A. K. , Oresic, M. , Hyötyläinen, T. , Arola, J. , Orho-Melander, M.
& et al.
(2020).
MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology, 73 (3), 725-726.
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Sen, P. , Dickens, A. M. , López-Bascón, M. A. , Lindeman, T. , Kemppainen, E. , Lamichhane, S. , Rönkkö, T. , Ilonen, J.
& et al.
(2020).
Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia, 63 (5), 1017-1031.
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Blanc, M. , Cormier, B. , Hyötyläinen, T. , Krauss, M. , Scherbak, N. , Cousin, X.
& Keiter, S. (2020).
Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47: Impact on growth, fertility, behavior and lipid metabolism. Ecotoxicology and Environmental Safety, 205.
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Fart, F. , Salihovic, S. , McGlinchey, A. J. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T.
& Schoultz, I. (2020).
Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis. Journal of Crohn's & Colitis, 14 (Suppl. 1), S138-S139.
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McGlinchey, A. J. , Sinioja, T. , Lamichhane, S. , Sen, P. , Bodin, J. , Siljander, H. , Dickens, A. M. , Geng, D.
& et al.
(2020).
Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes. Environment International, 143.
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Salihovic, S. , Dickens, A. M. , Schoultz, I. , Fart, F. , Sinisalu, L. , Lindeman, T. , Halfvarson, J. , Oresic, M.
& et al.
(2020).
Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 412 (10), 2251-2259.
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Ha, V. T. , Lainšček, D. , Gesslbauer, B. , Jarc-Jovičić, E. , Hyötyläinen, T. , Ilc, N. , Lakota, K. , Tomšič, M.
& et al.
(2020).
Synergy between 15-lipoxygenase and secreted PLA(2) promotes inflammation by formation of TLR4 agonists from extracellular vesicles. Proceedings of the National Academy of Sciences of the United States of America, 117 (41), 25679-25689.
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Qadri, S. , Lallukka-Brück, S. , Luukkonen, P. K. , Zhou, Y. , Gastaldelli, A. , Orho-Melander, M. , Sammalkorpi, H. , Juuti, A.
& et al.
(2020).
The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue. Liver international (Print), 40 (9), 2128-2138.
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Lamichhane, S. , Kemppainen, E. , Trošt, K. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2019).
Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia, 62 (12), 2287-2297.
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Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Dickens, A. M. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J.
& et al.
(2019).
Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules, 9 (1).
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Hernández-Alvarez, M. I. , Sebastián, D. , Vives, S. , Ivanova, S. , Bartoccioni, P. , Kakimoto, P. , Plana, N. , Veiga, S. R.
& et al.
(2019).
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell, 177 (4), 881-895.e17.
Information via DOI
Geng, D. , Musse, A. A. , Wigh, V. , Carlsson, C. , Engwall, M. , Oresic, M. , Scherbak, N.
& Hyötyläinen, T. (2019).
Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo. Ecotoxicology and Environmental Safety, 170, 691-698.
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Luukkonen, P. K. , Nick, A. , Hölttä-Vuori, M. , Thiele, C. , Isokuortti, E. , Lallukka-Brück, S. , Zhou, Y. , Hakkarainen, A.
& et al.
(2019).
Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. JCI Insight, 4 (16).
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Salihovic, S. , Fall, T. , Ganna, A. , Broeckling, C. D. , Prenni, J. E. , Hyötyläinen, T. , Kärrman, A. , Lind, P. M.
& et al.
(2019).
Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances. Journal of Exposure Science and Environmental Epidemiology, 29 (2), 196-205.
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Madrid-Gambin, F. , Focking, M. , Sabherwal, S. , Heurich, M. , English, J. A. , O'Gorman, A. , Suvitaival, T. , Ahonen, L.
& et al.
(2019).
Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children. Biological Psychiatry, 86 (1), 25-34.
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Sen, P. , Carlsson, C. , Virtanen, S. M. , Simell, S. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2019).
Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. Clinical and Translational Gastroenterology, 10.
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Djekic, D. , Pinto, R. , Repsilber, D. , Hyötyläinen, T.
& Henein, M. (2019).
Serum untargeted lipidomic profiling reveals dysfunction of phospholipid metabolism in subclinical coronary artery disease. Vascular Health and Risk Management, 15, 123-135.
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Ahonen, L. , Jäntti, S. , Suvitaival, T. , Theilade, S. , Risz, C. , Kostiainen, R. , Rossing, P. , Oresic, M.
& et al.
(2019).
Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients. Metabolites, 9 (9).
Information via DOIFull text in DiVA
Pedersen, H. K. , Forslund, S. K. , Gudmundsdottir, V. , Østergaard Petersen, A. , Hildebrand, F. , Hyötyläinen, T. , Nielsen, T. , Hansen, T.
& et al.
(2018).
A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links. Nature Protocols, 13 (12), 2781-2800.
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Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2018).
A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes. Scientific Data, 5.
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Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Kemppainen, E. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J.
& et al.
(2018).
Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP). Scientific Reports, 8.
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Suvitaival, T. , Bondia-Pons, I. , Yetukuri, L. , Pöhö, P. , Nolan, J. J. , Hyötyläinen, T. , Kuusisto, J.
& Orešič, M. (2018).
Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men. Metabolism: Clinical and Experimental, 78 (January), 1-12.
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Frank, E. , Maier, D. , Pajula, J. , Suvitaival, T. , Borgan, F. , Butz-Ostendorf, M. , Fischer, A. , Hietala, J.
& et al.
(2018).
Platform for systems medicine research and diagnostic applications in psychotic disorders - The METSY project. European psychiatry, 50, 40-46.
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Luukkonen, P. K. , Sädevirta, S. , Zhou, Y. , Kayser, B. , Ali, A. , Ahonen, L. , Lallukka, S. , Pelloux, V.
& et al.
(2018).
Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. Diabetes Care, 41 (8), 1732-1739.
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Posti, J. P. , Dickens, A. , Takala, R. S. , Ala-Seppälä, H. , Mattila, I. , Coles, J. P. , Frantzén, J. , Hutchinson, P. J.
& et al.
(2018).
SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY. Journal of Neurotrauma, 35 (16), A67-A67.
Dickens, A. M. , Posti, J. P. , Takala, R. S. , Ala-Seppälä, H. M. , Mattila, I. , Coles, J. C. , Frantzén, J. , Hutchinson, P. J.
& et al.
(2018).
Serum Metabolites Associated with Computed TomographyFindings after Traumatic Brain Injury. Journal of Neurotrauma, 35 (22), 2673-2683.
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Grip, T. , Dyrlund, T. S. , Ahonen, L. , Domellöf, M. , Hernell, O. , Hyötyläinen, T. , Knip, M. , Lönnerdal, B.
& et al.
(2018).
Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes. Pediatric Research, 84 (5), 726-732.
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Oresic, M. , Anderson, G. , Mattila, I. , Manoucheri, M. , Soininen, H. , Hyötyläinen, T.
& Basignani, C. (2018).
Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor. Frontiers in Neuroscience, 11.
Information via DOIFull text in DiVA
O'Gorman, A. , Suvitaival, T. , Ahonen, L. , Cannon, M. , Zammit, S. , Lewis, G. , Roche, H. M. , Mattila, I.
& et al.
(2017).
Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Translational Psychiatry, 7.
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Luukkonen, P. K. , Zhou, Y. , Haridas, N. P. A. , Dwivedi, O. P. , Hyötyläinen, T. , Ali, A. , Juuti, A. , Leivonen, M.
& et al.
(2017).
Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. Journal of Hepatology, 67 (1), 128-136.
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Jørgenrud, B. , Stene, L. C. , Tapia, G. , Bøås, H. , Pepaj, M. , Berg, J. P. , Thorsby, P. M. , Orešič, M.
& et al.
(2017).
Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study. Pediatric Diabetes, 18 (2), 111-119.
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Lankinen, M. , Schwab, U. , Kolehmainen, M. , Paananen, J. , Nygren, H. , Seppänen-Laakso, T. , Poutanen, K. , Hyötyläinen, T.
& et al.
(2016).
A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention. Journal of Nutrition, 146 (4), 662-672.
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Hyötyläinen, T. , Jerby, L. , Petäjä, E. M. , Mattila, I. , Jäntti, S. , Auvinen, P. , Gastaldelli, A. , Yki-Järvinen, H.
& et al.
(2016).
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Nature Communications, 7.
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Luukkonen, P. K. , Zhou, Y. , Sädevirta, S. , Leivonen, M. , Arola, J. , Oresic, M. , Hyötyläinen, T.
& Yki-Järvinen, H. (2016).
Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. Journal of Hepatology, 64 (5), 1167-1175.
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Pedersen, H. K. , Gudmundsdottir, V. , Nielsen, H. B. , Hyötyläinen, T. , Nielsen, T. , Jensen, B. A. H. , Forslund, K. , Hildebrand, F.
& et al.
(2016).
Human gut microbes impact host serum metabolome and insulin sensitivity. Nature, 535 (7612), 376-381.
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Oresic, M. , Posti, J. P. , Kamstrup-Nielsen, M. H. , Takala, R. S. K. , Lingsma, H. F. , Mattila, I. , Jäntti, S. , Katila, A. J.
& et al.
(2016).
Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury. EBioMedicine, 12, 118-126.
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Kurko, J. , Tringham, M. , Tanner, L. , Näntö-Salonen, K. , Vähä-Mäkilä, M. , Nygren, H. , Pöhö, P. , Lietzen, N.
& et al.
(2016).
Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI). Metabolism: Clinical and Experimental, 65 (9), 1361-1375.
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Zhou, Y. , Oresic, M. , Leivonen, M. , Gopalacharyulu, P. , Hyysalo, J. , Arola, J. , Verrijken, A. , Francque, S.
& et al.
(2016).
Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites. Clinical Gastroenterology and Hepatology, 14 (10), 1463-1472.e6.
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Aho, V. , Ollila, H. M. , Kronholm, E. , Bondia-Pons, I. , Soininen, P. , Kangas, A. J. , Hilvo, M. , Seppälä, I.
& et al.
(2016).
Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Scientific Reports, 6.
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Suvitaival, T. , Mantere, O. , Kieseppä, T. , Mattila, I. , Pöhö, P. , Hyötyläinen, T. , Suvisaari, J.
& Orešič, M. (2016).
Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis. Translational Psychiatry, 6 (11).
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Luukkonen, P. K. , Zhou, Y. , Hyötyläinen, T. , Leivonen, M. , Arola, J. , Orho-Melander, M. , Oresic, M.
& Yki-Järvinen, H. (2016).
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology, 65 (6), 1263-1265.
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Zhou, Y. , Llauradó, G. , Oresic, M. , Hyötyläinen, T. , Orho-Melander, M.
& Yki-Järvinen, H. (2015).
Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. Journal of Hepatology, 62 (3), 657-663.
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Polinati, P. P. , Ilmarinen, T. , Trokovic, R. , Hyötyläinen, T. , Otonkoski, T. , Suomalainen, A. , Skottman, H.
& Tynitiina, T. (2015).
Patient-specific induced pluripotent stem cell-derived RPE cells: Understanding the pathogenesis of retinopathy in long-chain 3-hydroxyacyl-CoA dehydrogenase deiciency. Investigative Ophthalmology and Visual Science, 56 (5), 3371-3382.
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Foerster, J. , Hyötyläinen, T. , Oresic, M. , Nygren, H.
& Boeing, H. (2015).
Serum Lipid and Serum Metabolite Components in relation to anthropometric parameters in EPIC-Potsdam participants. Metabolism: Clinical and Experimental, 64 (10), 1348-58.
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Kostic, A. D. , Gevers, D. , Siljander, H. , Vatanen, T. , Hyötyläinen, T. , Hämäläinen, A. , Peet, A. , Tillmann, V.
& et al.
(2015).
The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host and Microbe, 17 (2), 260-273.
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Hukkanen, J. , Puurunen, J. , Hyötyläinen, T. , Savolainen, M. J. , Ruokonen, A. , Morin-Papunen, L. , Oresic, M. , Piltonen, T.
& et al.
(2015).
The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity. British Journal of Clinical Pharmacology, 80 (3), 473-479.
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Jørgenrud, B. , Jäntti, S. , Mattila, I. , Pöhö, P. , Rønningen, K. S. , Yki-Järvinen, H. , Oresic, M.
& Hyötyläinen, T. (2015).
The influence of sample collection methodology and sample preprocessing on the blood metabolic profile.. Bioanalysis, 7 (8), 991-1006.
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Jørgenrud, B. , Jalanko, M. , Heliö, T. , Jääskeläinen, P. , Laine, M. , Hilvo, M. , Nieminen, M. S. , Laakso, M.
& et al.
(2015).
The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy. PLoS ONE, 10 (8).
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Naukkarinen, J. , Heinonen, S. , Hakkarainen, A. , Lundbom, J. , Vuolteenaho, K. , Saarinen, L. , Hautaniemi, S. , Rodriguez, A.
& et al.
(2014).
Characterising metabolically healthy obesity in weight-discordant monozygotic twins. Diabetologia, 57 (1), 167-176.
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Hyysalo, J. , Gopalacharyulu, P. , Bian, H. , Hyötyläinen, T. , Leivonen, M. , Jaser, N. , Juuti, A. , Honka, M.
& et al.
(2014).
Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity. Diabetes, 63 (1), 312-322.
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Snowden, S. G. , Grapov, D. , Settergren, M. , D'Alexandri, F. L. , Haeggström, J. Z. , Fiehn, O. , Hyötyläinen, T. , Pedersen, T. L.
& et al.
(2014).
High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy. Circulation: Cardiovascular Genetics, 7 (6), 955-964.
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Bondia-Pons, I. , Pöhö, P. , Bozzetto, L. , Vetrani, C. , Patti, L. , Aura, A. , Annuzzi, G. , Hyötyläinen, T.
& et al.
(2014).
Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk. Molecular Nutrition & Food Research, 58 (9), 1873-1882.
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Bondia-Pons, I. , Maukonen, J. , Mattila, I. , Rissanen, A. , Saarela, M. , Kaprio, J. , Hakkarainen, A. , Lundbom, J.
& et al.
(2014).
Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge. The FASEB Journal, 28 (9), 4169-4179.
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Hilvo, M. , Gade, S. , Hyötyläinen, T. , Nekljudova, V. , Seppänen-Laakso, T. , Sysi-Aho, M. , Untch, M. , Huober, J.
& et al.
(2014).
Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients. International Journal of Cancer, 134 (7), 1725-1733.
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Vetrani, C. , Rivellese, A. A. , Annuzzi, G. , Mattila, I. , Meudec, E. , Hyötyläinen, T. , Oresic, M.
& Aura, A. -. (2014).
Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. Food Research International, 63 (B), 233-238.
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Jäntti, S. E. , Kivilompolo, M. , Öhrnberg, L. , Pietiläinen, K. H. , Nygren, H. , Oresic, M.
& Hyötyläinen, T. (2014).
Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 406 (30), 7799-7815.
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Moravcová, D. , Haapala, M. , Planeta, J. , Hyötyläinen, T. , Kostiainen, R.
& Wiedmer, S. K. (2014).
Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry. Journal of Chromatography A, 1373, 90-96.
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Nygren, H. , Pöhö, P. , Seppänen-Laakso, T. , Lahtinen, U. , Oresic, M.
& Hyötyläinen, T. (2014).
Ultrahigh-performance liquid chromatography-mass spectrometry in Lipidomics. LC GC North America, 32 (4), 286-293.
Hartonen, M. , Mattila, I. , Ruskeepää, A. , Oresic, M.
& Hyötyläinen, T. (2013).
Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. Journal of Chromatography A, 1293, 142-149.
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Aura, A. , Mattila, I. , Hyötyläinen, T. , Gopalacharyulu, P. , Cheynier, V. , Souquet, J. , Bes, M. , Le Bourvellec, C.
& et al.
(2013).
Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches. European Journal of Nutrition, 52 (2), 833-846.
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Oresic, M. , Gopalacharyulu, P. , Mykkänen, J. , Lietzen, N. , Mäkinen, M. , Nygren, H. , Simell, S. , Simell, V.
& et al.
(2013).
Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes. Diabetes, 62 (9), 3268-3274.
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La Torre, D. , Seppänen-Laakso, T. , Larsson, H. E. , Hyötyläinen, T. , Ivarsson, S. A. , Lernmark, Å.
& Oresic, M. (2013).
Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes. Diabetes, 62 (11), 3951-3956.
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Laurila, P. , Surakka, I. , Sarin, A. , Yetukuri, L. , Hyötyläinen, T. , Söderlund, S. , Naukkarinen, J. , Tang, J.
& et al.
(2013).
Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol. Arteriosclerosis, Thrombosis and Vascular Biology, 33 (4), 847-857.
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Sayin, S. I. , Wahlström, A. , Felin, J. , Jäntti, S. , Marschall, H. , Bamberg, K. , Angelin, B. , Hyötyläinen, T.
& et al.
(2013).
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metabolism, 17 (2), 225-235.
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Havula, E. , Teesalu, M. , Hyötyläinen, T. , Seppälä, H. , Hasygar, K. , Auvinen, P. , Oresic, M. , Sandmann, T.
& et al.
(2013).
Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. PLoS Genetics, 9 (4).
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Orešič, M. , Hyötyläinen, T. , Kotronen, A. , Gopalacharyulu, P. , Nygren, H. , Arola, J. , Castillo, S. , Mattila, I.
& et al.
(2013).
Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. Diabetologia, 56 (10), 2266-2274.
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Jäntti, S. E. , Hartonen, M. , Hilvo, M. , Nygren, H. , Hyötyläinen, T. , Ketola, R. A.
& Kostiainen, R. (2013).
Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry. Analytica Chimica Acta, 802, 56-66.
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Nygren, H. , Pöhö, P. , Seppänen-Laakso, T. , Lahtinen, U. , Oresic, M.
& Hyötyläinen, T. (2013).
Ultrahigh-performance liquid chromatography-mass spectrometry in lipidomics. LC GC Europe, 26 (3), 142-148.
Wiedmer, S. K. , Robciuc, A. , Kronholm, J. , Holopainen, J. M.
& Hyötyläinen, T. (2012).
Chromatographic lipid profiling of stress-exposed cells. Journal of Separation Science, 35 (15), 1845-1853.
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Ottestad, I. , Hassani, S. , Borge, G. I. , Kohler, A. , Vogt, G. , Hyötyläinen, T. , Oresic, M. , Brønner, K. W.
& et al.
(2012).
Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLoS ONE, 7 (8).
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Hyötyläinen, T. , Mattila, I. , Wiedmer, S. K. , Koivuniemi, A. , Taskinen, M. , Yki-Järvinen, H.
& Oresic, M. (2012).
Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance. Molecular Biosystems, 8 (10), 2559-2565.
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Oresic, M. , Seppänen-Laakso, T. , Sun, D. , Tang, J. , Therman, S. , Viehman, R. , Mustonen, U. , van Erp, T. G.
& et al.
(2012).
Phospholipids and insulin resistance in psychosis: A lipidomics study of twin pairs discordant for schizophrenia. Genome Medicine, 4 (1).
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Ketola, K. , Hilvo, M. , Hyötyläinen, T. , Vuoristo, A. , Ruskeepää, A. L. , Oresic, M. , Kallioniemi, O. P.
& Iljin, K. (2012).
Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. British Journal of Cancer, 106 (1), 99-106.
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Pflueger, M. , Seppänen-Laakso, T. , Suortti, T. , Hyötyläinen, T. , Achenbach, P. , Bonifacio, E. , Oresic, M.
& Ziegler, A. (2011).
Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes. Diabetes, 60 (11), 2740-2747.
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Pietiläinen, K. H. , Róg, T. , Seppänen-Laakso, T. , Virtue, S. , Gopalacharyulu, P. , Tang, J. , Rodriguez-Cuenca, S. , Maciejewski, A.
& et al.
(2011).
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS biology, 9 (6).
Information via DOI
Castillo, S. , Mattila, I. , Miettinen, J. , Oresic, M.
& Hyötyläinen, T. (2011).
Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Analytical Chemistry, 83 (8), 3058-3067.
Information via DOI
Aura, A. , Mattila, I. , Hyötyläinen, T. , Gopalacharyulu, P. , Bounsaythip, C. , Oresic, M.
& Oksman-Caldentey, K. (2011).
Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro. Molecular Biosystems, 7 (2), 437-446.
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Götz, A. , Tyynismaa, H. , Euro, L. , Ellonen, P. , Hyötyläinen, T. , Ojala, T. , Hämäläinen, R. H. , Tommiska, J.
& et al.
(2011).
Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy. American Journal of Human Genetics, 88 (5), 635-642.
Information via DOI
Nygren, H. , Seppänen-Laakso, T. , Castillo, S. , Hyötyläinen, T.
& Oresic, M. (2011).
Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods in Molecular Biology, 708, 247-257.
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Orešič, M. , Hyötyläinen, T. , Herukka, S. , Sysi-Aho, M. , Mattila, I. , Seppänan-Laakso, T. , Julkunen, V. , Gopalacharyulu, P. V.
& et al.
(2011).
Metabolome in progression to Alzheimer's disease. Translational Psychiatry, 1.
Information via DOI
Oresic, M. , Tang, J. , Seppänen-Laakso, T. , Mattila, I. , Saarni, S. E. , Saarni, S. I. , Lönnqvist, J. , Sysi-Aho, M.
& et al.
(2011).
Metabolome in schizophrenia and other psychotic disorders: a general population-based study. Genome Medicine, 3 (3).
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Hilvo, M. , Denkert, C. , Lehtinen, L. , Müller, B. , Brockmöller, S. , Seppänen-Laakso, T. , Budczies, J. , Bucher, E.
& et al.
(2011).
Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Research, 71 (9), 3236-45.
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Pól, J. , Vidová, V. , Hyötyläinen, T. , Volný, M. , Novák, P. , Strohalm, M. , Kostiainen, R. , Havlíček, V.
& et al.
(2011).
Spatial distribution of glycerophospholipids in the ocular lens. PLoS ONE, 6 (4).
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Helle, A. , Hirsjärvi, S. , Peltonen, L. , Hirvonen, J. , Wiedmer, S. K.
& Hyötyläinen, T. (2010).
Novel, dynamic on-line analytical separation system for dissolution of drugs from poly(lactic acid) nanoparticles. Journal of Pharmaceutical and Biomedical Analysis, 51 (1), 125-130.
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Parshintsev, J. , Hyötyläinen, T. , Hartonen, K. , Kulmala, M.
& Riekkola, M. -. (2010).
Solid-phase extraction of organic compounds in atmospheric aerosol particles collected with the particle-into-liquid sampler and analysis by liquid chromatography-mass spectrometry. Talanta: The International Journal of Pure and Applied Analytical Chemistry, 80 (3), 1170-1176.
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Articles, reviews/surveys
Alves, M. A. , Lamichhane, S. , Dickens, A. , McGlinchey, A. J. , Ribeiro, H. C. , Sen, P. , Wei, F. , Hyötyläinen, T.
& et al.
(2021).
Systems biology approaches to study lipidomes in health and disease. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866 (2).
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Chapters in books
Manuscripts
Blanc, M. , Alfonso, S. , Bégout, M. , Barrachina, C. , Hyötyläinen, T. , Keiter, S.
& Cousin, X.
An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in exposed zebrafish and their unexposed F2 offspring.
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , De Vos, W. M.
& et al.
Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome.
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Lindqvist, C. M. , de Vos, W. , Brummer, R. J.
& König, J.
Faecal microbiota transfer in irritable bowel syndrome results inaltered correlations between the gut microbiota and its metabolites.
Blanc, M. , Cormier, B. , Hyötyläinen, T. , Krauss, M. , Scherbak, N. , Cousin, X.
& Keiter, S.
Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47 : impact on growth, fertility, behavior and lipid metabolism.