Tuulia Hyötyläinen
Title: Professor School/office: School of Science and Technology
Email:
Phone: +46 19 303487
Room: B3301
Research subject
Research environments
About Tuulia Hyötyläinen
I have started at Örebro University as professor of chemistry in 2016. I have a PhD in analytical chemistry from University of Helsinki, Finland. My main research interests are in metabolomics and in environmental studies.
My research focus in the metabolomics research is at the comprehensive analysis of all metabolites in a studied biological system that can describe metabolic changes caused by disease, environmental, nutritional, or genetic factors in an organism. For this, the goal in my research has been the development of efficient, high-throughput methodologies for profiling of the biological samples, based on both more conventional chromatographic methods as well as in comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry, ultra high performance liquid chromatography combined with various mass spectrometers. We have been developing both non-targeted profiling methods in discovery studies, as well as for targeted analysis of specific compounds, with the goal for as comprehensive coverage of the metabolome as possible. Here, the major goal is the development of more reliable and sensitive methodologies, particularly for comprehensive profiling of complex samples. Identification of unknown compounds with the mass spectrometric tools is the main challenge in the research. For this, development of software tools for the treatment of MS data has been a key issue as manual identification of hundreds or even thousands of unknown compounds in large sample series is not a viable option.
My main research areas currently are diabetes, fatty liver disease, traumatic brain injury and exposome studies. We have been able to identify specific biomarkers than enable diagnosis or even early prediction of the disease. Moreover, the goal is the identification of the metabolic pathways leading to the metabolic alterations, in specific diseases or due to different challenges such as environmental exposure of toxic substances, or various nutritional interventions.
Research projects
- Blood-based metabolomics to predict severity and patient outcomes in traumatic brain injury (meTBI)
- EPoS - Elucidating Pathways of Steatohepatitis
- Human exposome study
- Health Consequences of Environmental Exposures in Early Life
- ImprUV
- Butyrate-promoting dietary fibres as a potential strategy for the prevention of type-2 diabetes
- LITMUS
- Metabolic and Proteomic markers for Type 1 Diabetes
- Metabolomics signatures in medical and environmental pattern studies
- Mixture-Risk
- Mother-Infant Interactions in Relation to Potential Biomarkers of Beta-Cell Autoimmunity and Type 1 Diabetes
- Novel analytical and computational tools for the assessment of exposure to environmental chemicals
- PAC-Risk
- PFAS-Risk
- Role of environmental exposure in the initiation and progression of non-alcoholic fatty liver disease and insulin resistance
- Late onset of inflammatory bowel disease
Research teams
Publications
Articles in journals |
Articles, reviews/surveys |
Chapters in books |
Manuscripts |
Articles in journals
Sen, P. , Hyötyläinen, T.
& Oresic, M. (2021). 1-Deoxyceramides: key players in lipotoxicity and progression to type 2 diabetes?. Acta Physiologica.
Karpale, M. , Käräjämäki, A. J. , Kummu, O. , Gylling, H. , Hyötyläinen, T. , Oresic, M. , Tolonen, A. , Hautajärvi, H.
& et al.
(2021). Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2-mediated mechanism. British Journal of Pharmacology.
Blanc, M. , Alfonso, S. , Begout, M. , Barrachina, C. , Hyötyläinen, T. , Keiter, S. H.
& Cousin, X. (2021). An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. Science of the Total Environment, 754.
Hyötyläinen, T. (2021). Analytical challenges in human exposome analysis with focus on environmental analysis combined with metabolomics. Journal of Separation Science.
Lamichhane, S. , Dickens, A. M. , Sen, P. , Laurikainen, H. , Borgan, F. , Suvisaari, J. , Hyötyläinen, T. , Howes, O.
& et al.
(2021). Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis. Schizophrenia Bulletin, 47 (1), 160-169.
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , de Vos, W. M.
& et al.
(2021). Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome. Beneficial Microbes, 12 (1), 17-30.
Dickens, A. M. , Sen, P. , Kempton, M. J. , Barrantes-Vidal, N. , Iyegbe, C. , Nordentoft, M. , Pollak, T. , Riecher-Rössler, A.
& et al.
(2021). Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biological Psychiatry, 89 (3), 288-297.
Brial, F. , Chilloux, J. , Nielsen, T. , Vieira-Silva, S. , Falony, G. , Andrikopoulos, P. , Olanipekun, M. , Hoyles, L.
& et al.
(2021). Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. Gut.
Castro Alves, V. , Kalbina, I. , Nilsen, A. , Mats, A. , Rosenqvist, E. , Jansen, M. A. K. , Qian, M. , Öström, Å.
& et al.
(2021). Integration of non-target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality: A case study using dill (Anethum graveolens). Food Chemistry, 344.
Lamichhane, S. , Sen, P. , Alves, M. A. , Ribeiro, H. C. , Raunioniemi, P. , Hyötyläinen, T.
& Oresic, M. (2021). Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations. Metabolites, 11 (1).
Salonurmi, T. , Nabil, H. , Ronkainen, J. , Hyötyläinen, T. , Hautajärvi, H. , Savolainen, M. J. , Tolonen, A. , Oresic, M.
& et al.
(2020). 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.. Frontiers in Pharmacology, 11.
Sinisalu, L. , Sen, P. , Salihovic, S. , Virtanen, S. M. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2020). Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease. Environmental Research, 188.
Djekic, D. , Shi, L. , Calais, F. , Carlsson, F. , Landberg, R. , Hyötyläinen, T.
& Fröbert, O. (2020). Effects of a Lacto-Ovo-Vegetarian Diet on the Plasma Lipidome and Its Association with Atherosclerotic Burden in Patients with Coronary Artery Disease-A Randomized, Open-Label, Cross-over Study. Nutrients, 12 (11).
Luukkonen, P. K. , Tukiainen, T. , Juuti, A. , Sammalkorpi, H. , Haridas, P. A. N. , Niemelä, O. , Arola, J. , Orho-Melander, M.
& et al.
(2020). Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight, 5 (5).
Thomas, I. , Dickens, A. M. , Posti, J. P. , Mohammadian, M. , Ledig, C. , Takala, R. S. K. , Hyötyläinen, T. , Tenovuo, O.
& et al.
(2020). Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury. International Journal of Molecular Sciences, 21 (4).
Dickens, A. M. , Borgan, F. , Laurikainen, H. , Lamichhane, S. , Marques, T. , Rönkkö, T. , Veronese, M. , Lindeman, T.
& et al.
(2020). Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis. NPJ schizophrenia, 6 (1).
Luukkonen, P. K. , Juuti, A. , Sammalkorpi, H. , Penttilä, A. K. , Oresic, M. , Hyötyläinen, T. , Arola, J. , Orho-Melander, M.
& et al.
(2020). MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology, 73 (3), 725-726.
Sen, P. , Dickens, A. M. , López-Bascón, M. A. , Lindeman, T. , Kemppainen, E. , Lamichhane, S. , Rönkkö, T. , Ilonen, J.
& et al.
(2020). Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia, 63 (5), 1017-1031.
Blanc, M. , Cormier, B. , Hyötyläinen, T. , Krauss, M. , Scherbak, N. , Cousin, X.
& Keiter, S. (2020). Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47: Impact on growth, fertility, behavior and lipid metabolism. Ecotoxicology and Environmental Safety, 205.
Fart, F. , Salihovic, S. , McGlinchey, A. J. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T.
& Schoultz, I. (2020). Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis. Journal of Crohn's & Colitis, 14 (Suppl. 1), S138-S139.
McGlinchey, A. J. , Sinioja, T. , Lamichhane, S. , Sen, P. , Bodin, J. , Siljander, H. , Dickens, A. M. , Geng, D.
& et al.
(2020). Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes. Environment International, 143.
Salihovic, S. , Dickens, A. M. , Schoultz, I. , Fart, F. , Sinisalu, L. , Lindeman, T. , Halfvarson, J. , Oresic, M.
& et al.
(2020). Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 412 (10), 2251-2259.
Ha, V. T. , Lainšček, D. , Gesslbauer, B. , Jarc-Jovičić, E. , Hyötyläinen, T. , Ilc, N. , Lakota, K. , Tomšič, M.
& et al.
(2020). Synergy between 15-lipoxygenase and secreted PLA(2) promotes inflammation by formation of TLR4 agonists from extracellular vesicles. Proceedings of the National Academy of Sciences of the United States of America, 117 (41), 25679-25689.
Qadri, S. , Lallukka-Brück, S. , Luukkonen, P. K. , Zhou, Y. , Gastaldelli, A. , Orho-Melander, M. , Sammalkorpi, H. , Juuti, A.
& et al.
(2020). The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue. Liver international (Print), 40 (9), 2128-2138.
Castro Alves, V. , Kalbina, I. , Öström, Å. , Hyötyläinen, T.
& Strid, Å. (2020). The taste of UV light: Using sensomics to improve horticultural quality. UV4Plants Bulletin (1), 39-43.
Lamichhane, S. , Kemppainen, E. , Trošt, K. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2019). Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia, 62 (12), 2287-2297.
Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Dickens, A. M. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J.
& et al.
(2019). Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules, 9 (1).
Hernández-Alvarez, M. I. , Sebastián, D. , Vives, S. , Ivanova, S. , Bartoccioni, P. , Kakimoto, P. , Plana, N. , Veiga, S. R.
& et al.
(2019). Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell, 177 (4), 881-895.e17.
Geng, D. , Musse, A. A. , Wigh, V. , Carlsson, C. , Engwall, M. , Oresic, M. , Scherbak, N.
& Hyötyläinen, T. (2019). Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo. Ecotoxicology and Environmental Safety, 170, 691-698.
Luukkonen, P. K. , Nick, A. , Hölttä-Vuori, M. , Thiele, C. , Isokuortti, E. , Lallukka-Brück, S. , Zhou, Y. , Hakkarainen, A.
& et al.
(2019). Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. JCI Insight, 4 (16).
Salihovic, S. , Fall, T. , Ganna, A. , Broeckling, C. D. , Prenni, J. E. , Hyötyläinen, T. , Kärrman, A. , Lind, P. M.
& et al.
(2019). Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances. Journal of Exposure Science and Environmental Epidemiology, 29 (2), 196-205.
Madrid-Gambin, F. , Focking, M. , Sabherwal, S. , Heurich, M. , English, J. A. , O'Gorman, A. , Suvitaival, T. , Ahonen, L.
& et al.
(2019). Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children. Biological Psychiatry, 86 (1), 25-34.
Sen, P. , Carlsson, C. , Virtanen, S. M. , Simell, S. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2019). Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. Clinical and Translational Gastroenterology, 10.
Djekic, D. , Pinto, R. , Repsilber, D. , Hyötyläinen, T.
& Henein, M. (2019). Serum untargeted lipidomic profiling reveals dysfunction of phospholipid metabolism in subclinical coronary artery disease. Vascular Health and Risk Management, 15, 123-135.
Ahonen, L. , Jäntti, S. , Suvitaival, T. , Theilade, S. , Risz, C. , Kostiainen, R. , Rossing, P. , Oresic, M.
& et al.
(2019). Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients. Metabolites, 9 (9).
Liu, G. , Hyötyläinen, T.
& Falandysz, J. (2019). Toxicology and Environmental Characteristics of emerging pollutants. Ecotoxicology and Environmental Safety, 181, 264-264.
Pedersen, H. K. , Forslund, S. K. , Gudmundsdottir, V. , Østergaard Petersen, A. , Hildebrand, F. , Hyötyläinen, T. , Nielsen, T. , Hansen, T.
& et al.
(2018). A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links. Nature Protocols, 13 (12), 2781-2800.
Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2018). A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes. Scientific Data, 5.
Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Kemppainen, E. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J.
& et al.
(2018). Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP). Scientific Reports, 8.
Suvitaival, T. , Bondia-Pons, I. , Yetukuri, L. , Pöhö, P. , Nolan, J. J. , Hyötyläinen, T. , Kuusisto, J.
& Orešič, M. (2018). Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men. Metabolism: Clinical and Experimental, 78 (January), 1-12.
Frank, E. , Maier, D. , Pajula, J. , Suvitaival, T. , Borgan, F. , Butz-Ostendorf, M. , Fischer, A. , Hietala, J.
& et al.
(2018). Platform for systems medicine research and diagnostic applications in psychotic disorders - The METSY project. European psychiatry, 50, 40-46.
Luukkonen, P. K. , Sädevirta, S. , Zhou, Y. , Kayser, B. , Ali, A. , Ahonen, L. , Lallukka, S. , Pelloux, V.
& et al.
(2018). Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. Diabetes Care, 41 (8), 1732-1739.
Posti, J. P. , Dickens, A. , Takala, R. S. , Ala-Seppälä, H. , Mattila, I. , Coles, J. P. , Frantzén, J. , Hutchinson, P. J.
& et al.
(2018). SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY. Journal of Neurotrauma, 35 (16), A67-A67.
Dickens, A. M. , Posti, J. P. , Takala, R. S. , Ala-Seppälä, H. M. , Mattila, I. , Coles, J. C. , Frantzén, J. , Hutchinson, P. J.
& et al.
(2018). Serum Metabolites Associated with Computed TomographyFindings after Traumatic Brain Injury. Journal of Neurotrauma, 35 (22), 2673-2683.
Grip, T. , Dyrlund, T. S. , Ahonen, L. , Domellöf, M. , Hernell, O. , Hyötyläinen, T. , Knip, M. , Lönnerdal, B.
& et al.
(2018). Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes. Pediatric Research, 84 (5), 726-732.
Oresic, M. , Anderson, G. , Mattila, I. , Manoucheri, M. , Soininen, H. , Hyötyläinen, T.
& Basignani, C. (2018). Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor. Frontiers in Neuroscience, 11.
Bowden, J. A. , Hyötyläinen, T. , Oresic, M.
& Zhou, S. (2017). Harmonizing Lipidomics: NIST Interlaboratory Comparison Exercise for Lipidomics using Standard Reference Material 1950 Metabolites in Frozen Human Plasma. Journal of Lipid Research, 58 (12), 2275-2288.
O'Gorman, A. , Suvitaival, T. , Ahonen, L. , Cannon, M. , Zammit, S. , Lewis, G. , Roche, H. M. , Mattila, I.
& et al.
(2017). Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Translational Psychiatry, 7.
Luukkonen, P. K. , Zhou, Y. , Haridas, N. P. A. , Dwivedi, O. P. , Hyötyläinen, T. , Ali, A. , Juuti, A. , Leivonen, M.
& et al.
(2017). Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. Journal of Hepatology, 67 (1), 128-136.
Hyötyläinen, T. , Ahonen, L. , Pöhö, P.
& Oresic, M. (2017). Lipidomics in biomedical research-practical considerations. Biochimica et Biophysica Acta, 1862 (8), 800-803.
Jørgenrud, B. , Stene, L. C. , Tapia, G. , Bøås, H. , Pepaj, M. , Berg, J. P. , Thorsby, P. M. , Orešič, M.
& et al.
(2017). Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study. Pediatric Diabetes, 18 (2), 111-119.
Lankinen, M. , Schwab, U. , Kolehmainen, M. , Paananen, J. , Nygren, H. , Seppänen-Laakso, T. , Poutanen, K. , Hyötyläinen, T.
& et al.
(2016). A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention. Journal of Nutrition, 146 (4), 662-672.
Hyötyläinen, T.
& Orešič, M. (2016). Bioanalytical techniques in nontargeted clinical lipidomics. Bioanalysis, 8 (4), 351-364.
Hyötyläinen, T. , Jerby, L. , Petäjä, E. M. , Mattila, I. , Jäntti, S. , Auvinen, P. , Gastaldelli, A. , Yki-Järvinen, H.
& et al.
(2016). Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Nature Communications, 7.
Luukkonen, P. K. , Zhou, Y. , Sädevirta, S. , Leivonen, M. , Arola, J. , Oresic, M. , Hyötyläinen, T.
& Yki-Järvinen, H. (2016). Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. Journal of Hepatology, 64 (5), 1167-1175.
Pedersen, H. K. , Gudmundsdottir, V. , Nielsen, H. B. , Hyötyläinen, T. , Nielsen, T. , Jensen, B. A. H. , Forslund, K. , Hildebrand, F.
& et al.
(2016). Human gut microbes impact host serum metabolome and insulin sensitivity. Nature, 535 (7612), 376-381.
Oresic, M. , Posti, J. P. , Kamstrup-Nielsen, M. H. , Takala, R. S. K. , Lingsma, H. F. , Mattila, I. , Jäntti, S. , Katila, A. J.
& et al.
(2016). Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury. EBioMedicine, 12, 118-126.
Kurko, J. , Tringham, M. , Tanner, L. , Näntö-Salonen, K. , Vähä-Mäkilä, M. , Nygren, H. , Pöhö, P. , Lietzen, N.
& et al.
(2016). Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI). Metabolism: Clinical and Experimental, 65 (9), 1361-1375.
Zhou, Y. , Oresic, M. , Leivonen, M. , Gopalacharyulu, P. , Hyysalo, J. , Arola, J. , Verrijken, A. , Francque, S.
& et al.
(2016). Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites. Clinical Gastroenterology and Hepatology, 14 (10), 1463-1472.e6.
Aho, V. , Ollila, H. M. , Kronholm, E. , Bondia-Pons, I. , Soininen, P. , Kangas, A. J. , Hilvo, M. , Seppälä, I.
& et al.
(2016). Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Scientific Reports, 6.
Suvitaival, T. , Mantere, O. , Kieseppä, T. , Mattila, I. , Pöhö, P. , Hyötyläinen, T. , Suvisaari, J.
& Orešič, M. (2016). Serum metabolite profile associates with the development of metabolic co-morbidities in first-episode psychosis. Translational Psychiatry, 6 (11).
Luukkonen, P. K. , Zhou, Y. , Hyötyläinen, T. , Leivonen, M. , Arola, J. , Orho-Melander, M. , Oresic, M.
& Yki-Järvinen, H. (2016). The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology, 65 (6), 1263-1265.
Hyötyläinen, T.
& Orešič, M. (2015). Analytical Lipidomics in Metabolic and Clinical Research. Trends in endocrinology and metabolism, 26 (12), 671-673.
Zhou, Y. , Llauradó, G. , Oresic, M. , Hyötyläinen, T. , Orho-Melander, M.
& Yki-Järvinen, H. (2015). Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. Journal of Hepatology, 62 (3), 657-663.
Parshintsev, J.
& Hyötyläinen, T. (2015). Methods for characterization of organic compounds in atmospheric aerosol particles. Analytical and Bioanalytical Chemistry, 407 (20), 5877-5897.
Polinati, P. P. , Ilmarinen, T. , Trokovic, R. , Hyötyläinen, T. , Otonkoski, T. , Suomalainen, A. , Skottman, H.
& Tynitiina, T. (2015). Patient-specific induced pluripotent stem cell-derived RPE cells: Understanding the pathogenesis of retinopathy in long-chain 3-hydroxyacyl-CoA dehydrogenase deiciency. Investigative Ophthalmology and Visual Science, 56 (5), 3371-3382.
Foerster, J. , Hyötyläinen, T. , Oresic, M. , Nygren, H.
& Boeing, H. (2015). Serum Lipid and Serum Metabolite Components in relation to anthropometric parameters in EPIC-Potsdam participants. Metabolism: Clinical and Experimental, 64 (10), 1348-58.
Kostic, A. D. , Gevers, D. , Siljander, H. , Vatanen, T. , Hyötyläinen, T. , Hämäläinen, A. , Peet, A. , Tillmann, V.
& et al.
(2015). The dynamics of the human infant gut microbiome in development and in progression toward type 1 diabetes. Cell Host and Microbe, 17 (2), 260-273.
Hukkanen, J. , Puurunen, J. , Hyötyläinen, T. , Savolainen, M. J. , Ruokonen, A. , Morin-Papunen, L. , Oresic, M. , Piltonen, T.
& et al.
(2015). The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity. British Journal of Clinical Pharmacology, 80 (3), 473-479.
Jørgenrud, B. , Jäntti, S. , Mattila, I. , Pöhö, P. , Rønningen, K. S. , Yki-Järvinen, H. , Oresic, M.
& Hyötyläinen, T. (2015). The influence of sample collection methodology and sample preprocessing on the blood metabolic profile.. Bioanalysis, 7 (8), 991-1006.
Jørgenrud, B. , Jalanko, M. , Heliö, T. , Jääskeläinen, P. , Laine, M. , Hilvo, M. , Nieminen, M. S. , Laakso, M.
& et al.
(2015). The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy. PLoS ONE, 10 (8).
Naukkarinen, J. , Heinonen, S. , Hakkarainen, A. , Lundbom, J. , Vuolteenaho, K. , Saarinen, L. , Hautaniemi, S. , Rodriguez, A.
& et al.
(2014). Characterising metabolically healthy obesity in weight-discordant monozygotic twins. Diabetologia, 57 (1), 167-176.
Hyysalo, J. , Gopalacharyulu, P. , Bian, H. , Hyötyläinen, T. , Leivonen, M. , Jaser, N. , Juuti, A. , Honka, M.
& et al.
(2014). Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity. Diabetes, 63 (1), 312-322.
Snowden, S. G. , Grapov, D. , Settergren, M. , D'Alexandri, F. L. , Haeggström, J. Z. , Fiehn, O. , Hyötyläinen, T. , Pedersen, T. L.
& et al.
(2014). High-dose simvastatin exhibits enhanced lipid-lowering effects relative to simvastatin/ezetimibe combination therapy. Circulation: Cardiovascular Genetics, 7 (6), 955-964.
Bondia-Pons, I. , Pöhö, P. , Bozzetto, L. , Vetrani, C. , Patti, L. , Aura, A. , Annuzzi, G. , Hyötyläinen, T.
& et al.
(2014). Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk. Molecular Nutrition & Food Research, 58 (9), 1873-1882.
Bondia-Pons, I. , Maukonen, J. , Mattila, I. , Rissanen, A. , Saarela, M. , Kaprio, J. , Hakkarainen, A. , Lundbom, J.
& et al.
(2014). Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge. The FASEB Journal, 28 (9), 4169-4179.
Hilvo, M. , Gade, S. , Hyötyläinen, T. , Nekljudova, V. , Seppänen-Laakso, T. , Sysi-Aho, M. , Untch, M. , Huober, J.
& et al.
(2014). Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients. International Journal of Cancer, 134 (7), 1725-1733.
Vetrani, C. , Rivellese, A. A. , Annuzzi, G. , Mattila, I. , Meudec, E. , Hyötyläinen, T. , Oresic, M.
& Aura, A. -. (2014). Phenolic metabolites as compliance biomarker for polyphenol intake in a randomized controlled human intervention. Food Research International, 63 (B), 233-238.
Jäntti, S. E. , Kivilompolo, M. , Öhrnberg, L. , Pietiläinen, K. H. , Nygren, H. , Oresic, M.
& Hyötyläinen, T. (2014). Quantitative profiling of bile acids in blood, adipose tissue, intestine, and gall bladder samples using ultra high performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 406 (30), 7799-7815.
Moravcová, D. , Haapala, M. , Planeta, J. , Hyötyläinen, T. , Kostiainen, R.
& Wiedmer, S. K. (2014). Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry. Journal of Chromatography A, 1373, 90-96.
Greiner, T. U. , Hyötyläinen, T. , Knip, M. , Bäckhed, F.
& Oresic, M. (2014). The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice. PLoS ONE, 9 (11).
Nygren, H. , Pöhö, P. , Seppänen-Laakso, T. , Lahtinen, U. , Oresic, M.
& Hyötyläinen, T. (2014). Ultrahigh-performance liquid chromatography-mass spectrometry in Lipidomics. LC GC North America, 32 (4), 286-293.
Hartonen, M. , Mattila, I. , Ruskeepää, A. , Oresic, M.
& Hyötyläinen, T. (2013). Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. Journal of Chromatography A, 1293, 142-149.
Aura, A. , Mattila, I. , Hyötyläinen, T. , Gopalacharyulu, P. , Cheynier, V. , Souquet, J. , Bes, M. , Le Bourvellec, C.
& et al.
(2013). Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches. European Journal of Nutrition, 52 (2), 833-846.
Oresic, M. , Gopalacharyulu, P. , Mykkänen, J. , Lietzen, N. , Mäkinen, M. , Nygren, H. , Simell, S. , Simell, V.
& et al.
(2013). Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes. Diabetes, 62 (9), 3268-3274.
La Torre, D. , Seppänen-Laakso, T. , Larsson, H. E. , Hyötyläinen, T. , Ivarsson, S. A. , Lernmark, Å.
& Oresic, M. (2013). Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes. Diabetes, 62 (11), 3951-3956.
Laurila, P. , Surakka, I. , Sarin, A. , Yetukuri, L. , Hyötyläinen, T. , Söderlund, S. , Naukkarinen, J. , Tang, J.
& et al.
(2013). Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterol. Arteriosclerosis, Thrombosis and Vascular Biology, 33 (4), 847-857.
Sayin, S. I. , Wahlström, A. , Felin, J. , Jäntti, S. , Marschall, H. , Bamberg, K. , Angelin, B. , Hyötyläinen, T.
& et al.
(2013). Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metabolism, 17 (2), 225-235.
Havula, E. , Teesalu, M. , Hyötyläinen, T. , Seppälä, H. , Hasygar, K. , Auvinen, P. , Oresic, M. , Sandmann, T.
& et al.
(2013). Mondo/ChREBP-Mlx-regulated transcriptional network is essential for dietary sugar tolerance in Drosophila. PLoS Genetics, 9 (4).
Orešič, M. , Hyötyläinen, T. , Kotronen, A. , Gopalacharyulu, P. , Nygren, H. , Arola, J. , Castillo, S. , Mattila, I.
& et al.
(2013). Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. Diabetologia, 56 (10), 2266-2274.
Kivilompolo, M. , Öhrnberg, L. , Oresic, M.
& Hyötyläinen, T. (2013). Rapid quantitative analysis of carnitine and acylcarnitines by ultra-high performance-hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1292, 189-194.
Jäntti, S. E. , Hartonen, M. , Hilvo, M. , Nygren, H. , Hyötyläinen, T. , Ketola, R. A.
& Kostiainen, R. (2013). Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry. Analytica Chimica Acta, 802, 56-66.
Nygren, H. , Pöhö, P. , Seppänen-Laakso, T. , Lahtinen, U. , Oresic, M.
& Hyötyläinen, T. (2013). Ultrahigh-performance liquid chromatography-mass spectrometry in lipidomics. LC GC Europe, 26 (3), 142-148.
Wiedmer, S. K. , Robciuc, A. , Kronholm, J. , Holopainen, J. M.
& Hyötyläinen, T. (2012). Chromatographic lipid profiling of stress-exposed cells. Journal of Separation Science, 35 (15), 1845-1853.
Ottestad, I. , Hassani, S. , Borge, G. I. , Kohler, A. , Vogt, G. , Hyötyläinen, T. , Oresic, M. , Brønner, K. W.
& et al.
(2012). Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects. PLoS ONE, 7 (8).
Robciuc, A. , Hyötyläinen, T. , Jauhiainen, M.
& Holopainen, J. M. (2012). Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2. Journal of Lipid Research, 53 (11), 2286-2295.
Hyötyläinen, T. , Mattila, I. , Wiedmer, S. K. , Koivuniemi, A. , Taskinen, M. , Yki-Järvinen, H.
& Oresic, M. (2012). Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance. Molecular Biosystems, 8 (10), 2559-2565.
Hyötyläinen, T. (2012). Novel methodologies in metabolic profiling with a focus on molecular diagnostic applications. Expert Review of Molecular Diagnostics, 12 (5), 527-538.
Oresic, M. , Seppänen-Laakso, T. , Sun, D. , Tang, J. , Therman, S. , Viehman, R. , Mustonen, U. , van Erp, T. G.
& et al.
(2012). Phospholipids and insulin resistance in psychosis: A lipidomics study of twin pairs discordant for schizophrenia. Genome Medicine, 4 (1).
Ketola, K. , Hilvo, M. , Hyötyläinen, T. , Vuoristo, A. , Ruskeepää, A. L. , Oresic, M. , Kallioniemi, O. P.
& Iljin, K. (2012). Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. British Journal of Cancer, 106 (1), 99-106.
Pflueger, M. , Seppänen-Laakso, T. , Suortti, T. , Hyötyläinen, T. , Achenbach, P. , Bonifacio, E. , Oresic, M.
& Ziegler, A. (2011). Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes. Diabetes, 60 (11), 2740-2747.
Pietiläinen, K. H. , Róg, T. , Seppänen-Laakso, T. , Virtue, S. , Gopalacharyulu, P. , Tang, J. , Rodriguez-Cuenca, S. , Maciejewski, A.
& et al.
(2011). Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS biology, 9 (6).
Castillo, S. , Mattila, I. , Miettinen, J. , Oresic, M.
& Hyötyläinen, T. (2011). Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Analytical Chemistry, 83 (8), 3058-3067.
Aura, A. , Mattila, I. , Hyötyläinen, T. , Gopalacharyulu, P. , Bounsaythip, C. , Oresic, M.
& Oksman-Caldentey, K. (2011). Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro. Molecular Biosystems, 7 (2), 437-446.
Götz, A. , Tyynismaa, H. , Euro, L. , Ellonen, P. , Hyötyläinen, T. , Ojala, T. , Hämäläinen, R. H. , Tommiska, J.
& et al.
(2011). Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy. American Journal of Human Genetics, 88 (5), 635-642.
Nygren, H. , Seppänen-Laakso, T. , Castillo, S. , Hyötyläinen, T.
& Oresic, M. (2011). Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods in Molecular Biology, 708, 247-257.
Orešič, M. , Hyötyläinen, T. , Herukka, S. , Sysi-Aho, M. , Mattila, I. , Seppänan-Laakso, T. , Julkunen, V. , Gopalacharyulu, P. V.
& et al.
(2011). Metabolome in progression to Alzheimer's disease. Translational Psychiatry, 1.
Oresic, M. , Tang, J. , Seppänen-Laakso, T. , Mattila, I. , Saarni, S. E. , Saarni, S. I. , Lönnqvist, J. , Sysi-Aho, M.
& et al.
(2011). Metabolome in schizophrenia and other psychotic disorders: a general population-based study. Genome Medicine, 3 (3).
Hilvo, M. , Denkert, C. , Lehtinen, L. , Müller, B. , Brockmöller, S. , Seppänen-Laakso, T. , Budczies, J. , Bucher, E.
& et al.
(2011). Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Research, 71 (9), 3236-45.
Pól, J. , Vidová, V. , Hyötyläinen, T. , Volný, M. , Novák, P. , Strohalm, M. , Kostiainen, R. , Havlíček, V.
& et al.
(2011). Spatial distribution of glycerophospholipids in the ocular lens. PLoS ONE, 6 (4).
Hyötyläinen, T. (2010). Analytical methodologies utilized in the search for chronic disease biomarkers. Bioanalysis, 2 (5), 919-923.
Helle, A. , Hirsjärvi, S. , Peltonen, L. , Hirvonen, J. , Wiedmer, S. K.
& Hyötyläinen, T. (2010). Novel, dynamic on-line analytical separation system for dissolution of drugs from poly(lactic acid) nanoparticles. Journal of Pharmaceutical and Biomedical Analysis, 51 (1), 125-130.
Parshintsev, J. , Hyötyläinen, T. , Hartonen, K. , Kulmala, M.
& Riekkola, M. -. (2010). Solid-phase extraction of organic compounds in atmospheric aerosol particles collected with the particle-into-liquid sampler and analysis by liquid chromatography-mass spectrometry. Talanta: The International Journal of Pure and Applied Analytical Chemistry, 80 (3), 1170-1176.
Articles, reviews/surveys
Alves, M. A. , Lamichhane, S. , Dickens, A. , McGlinchey, A. J. , Ribeiro, H. C. , Sen, P. , Wei, F. , Hyötyläinen, T.
& et al.
(2021). Systems biology approaches to study lipidomes in health and disease. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866 (2).
Oresic, M. , McGlinchey, A. J. , Wheelock, C. E.
& Hyötyläinen, T. (2020). Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health. Metabolites, 10 (11).
Fang, W. , Santosh, L. , Oresic, M.
& Hyötyläinen, T. (2019). Lipidomes in health and disease: Analytical strategies and considerations. TrAC. Trends in analytical chemistry, 120.
Posti, J. P. , Dickens, A. M. , Orešič, M. , Hyötyläinen, T.
& Tenovuo, O. (2017). Metabolomics Profiling As a Diagnostic Tool in Severe Traumatic Brain injury. Frontiers in Neurology, 8.
Hyötyläinen, T.
& Oresic, M. (2015). Optimizing the lipidomics workflow for clinical studies: practical considerations. Analytical and Bioanalytical Chemistry, 407 (17), 4973-4993.
Hyötyläinen, T.
& Oresic, M. (2014). Systems biology strategies to study lipidomes in health and disease. Progress in lipid research, 55 (1), 43-60.
Robciuc, A. , Hyötyläinen, T. , Jauhiainen, M.
& Holopainen, J. M. (2013). Ceramides in the pathophysiology of the anterior segment of the eye. Current Eye Research, 38 (10), 1006-1016.
Hyötyläinen, T. , Bondia-Pons, I.
& Oresic, M. (2013). Lipidomics in nutrition and food research. Molecular Nutrition & Food Research, 57 (8), 1306-1318.
Chapters in books
Lamichhane, S. , Sen, P. , Dickens, A. M. , Hyötyläinen, T.
& Orešič, M. (2018). An Overview of Metabolomics Data Analysis: Current Tools and Future Perspectives.
In:
Joaquim Jaumot; Carmen Bedia; Romà Tauler, Data Analysis for Omic Sciences: Methods and Applications (pp. 387-413).
. Elsevier.
Manuscripts
Blanc, M. , Alfonso, S. , Bégout, M. , Barrachina, C. , Hyötyläinen, T. , Keiter, S.
& Cousin, X. An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in exposed zebrafish and their unexposed F2 offspring.
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , De Vos, W. M.
& et al.
Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome.
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Lindqvist, C. M. , de Vos, W. , Brummer, R. J.
& König, J. Faecal microbiota transfer in irritable bowel syndrome results inaltered correlations between the gut microbiota and its metabolites.
Blanc, M. , Cormier, B. , Hyötyläinen, T. , Krauss, M. , Scherbak, N. , Cousin, X.
& Keiter, S. Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47 : impact on growth, fertility, behavior and lipid metabolism.