Tuulia Hyötyläinen
Tuulia Hyötyläinen Befattning: Professor Organisation: Institutionen för naturvetenskap och teknikE-post: dHV1bGlhLmh5b3R5bGFpbmVuO29ydS5zZQ==
Telefon: 019 303487
Rum: B3304
- Forskningscentrum Människa-Teknik-Miljö (MTM)
- Nutrition-Gut-Brain Interactions Research Centre (NGBI)
-
Responsive Nutrition Research Centre
Om Tuulia Hyötyläinen
I have started at Örebro University as professor of chemistry in 2016. I have a PhD in analytical chemistry from University of Helsinki, Finland. My main research interests are in metabolomics and in environmental studies.
My research focus in the metabolomics research is at the comprehensive analysis of all metabolites in a studied biological system that can describe metabolic changes caused by disease, environmental, nutritional, or genetic factors in an organism. For this, the goal in my research has been the development of efficient, high-throughput methodologies for profiling of the biological samples, based on both more conventional chromatographic methods as well as in comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry, ultra high performance liquid chromatography combined with various mass spectrometers. We have been developing both non-targeted profiling methods in discovery studies, as well as for targeted analysis of specific compounds, with the goal for as comprehensive coverage of the metabolome as possible. Here, the major goal is the development of more reliable and sensitive methodologies, particularly for comprehensive profiling of complex samples. Identification of unknown compounds with the mass spectrometric tools is the main challenge in the research. For this, development of software tools for the treatment of MS data has been a key issue as manual identification of hundreds or even thousands of unknown compounds in large sample series is not a viable option.
My main research areas currently are diabetes, fatty liver disease, traumatic brain injury and exposome studies. We have been able to identify specific biomarkers than enable diagnosis or even early prediction of the disease. Moreover, the goal is the identification of the metabolic pathways leading to the metabolic alterations, in specific diseases or due to different challenges such as environmental exposure of toxic substances, or various nutritional interventions.
Forskningsprojekt
Pågående projekt
- Data Infrastructure and Molecular Atlas for Alzheimer's Disease: Connecting Exposome, Gut Microbiome, and Metabolome
- ImprUV+ - An analytical framework to explore the effects of UV during plant growth on human health
- Inflammation i människans tidiga liv: inriktning på effekter på livsloppshälsan
- Interaction between dietary protein and fibre fermentation - its functional consequences
- Kostfibrer som främjar smörsyra-producerande bakterier som en möjlig förebyggande terapi vid typ-2 diabetes
- LITMUS
- Metabolom vid traumatisk hjärnskada - från biomarkörer och pathways till klinisk översättning
- Metabolomics signatures in medical and environmental pattern studies
- Mixture-Risk
- NanoSafety2
- Nature versus Machine - Using novel robotics platforms for mechanical stress induction, and their effects on plant morphology, metabolism, and sensory preference
- Novel analytical and computational tools for the assessment of exposure to environmental chemicals
- PAC-Risk
- PAN Protein - plant-based proteins contributing to a healthy and sustainable diet
- PFAS-Risk
- Plant responses to ultraviolet radiation and blue light: from perception to crop production
- POPgut - The impact of persistent organic pollutants exposure on gut health
- Rewine The World - Ett projekt för att utveckla nya multidisciplinära metoder för minskat matsvinn och ökad resursanvändning av komplexa livsmedel
- Role of environmental exposure in the initiation and progression of non-alcoholic fatty liver disease and insulin resistance
- Sen debut av inflammatorisk tarmsjukdom
- Undersökning av hormonstörande kemikalier som bidrar till progression av metabolisk dysfunktion associerad steatotisk leversjukdom
- Unpuzzle - Unravelling molecular motifs from dietary fibers responsible for interaction with recognition receptors in human cells
- Utveckling av verktygslåda för exposom- och metabolomiska analyser (MeET)
Avslutade projekt
- Blodbaserad metabolomik för att förutsäga svårighetsgrad och patient prognos vid traumatisk hjärnskada (meTBI)
- EPoS - Elucidating Pathways of Steatohepatitis
- Human exposome study
- Hälsoeffekter av miljöexponering tidigt i livet
- ImprUV - Increasing sensory quality and content of health-promoting components in vegetables and herbs
- Matvanor och fysisk aktivitet för hälsa och välbefinnande
- Metabolic and Proteomic markers for Type 1 Diabetes
- Mother-Infant Interactions in Relation to Potential Biomarkers of Beta-Cell Autoimmunity and Type 1 Diabetes
Forskargrupper
Publikationer
Artiklar i tidskrifter
- Nilén, G. , Larsson, M. , Hyötyläinen, T. & Keiter, S. (2024). A complex mixture of polycyclic aromatic compounds causes embryotoxic, behavioral, and molecular effects in zebrafish larvae (Danio rerio), and in vitro bioassays. Science of the Total Environment, 906. [BibTeX]
- Herzig, M. , Hyötyläinen, T. , Vettese, G. F. , Law, G. T. W. , Vierinen, T. & Bomberg, M. (2024). Altering environmental conditions induce shifts in simulated deep terrestrial subsurface bacterial communities-Secretion of primary and secondary metabolites. Environmental Microbiology, 26 (1). [BibTeX]
- Isokääntä, H. , Pinto da Silva, L. , Karu, N. , Kallonen, T. , Aatsinki, A. , Hankemeier, T. , Schimmel, L. , Diaz, E. & et al. (2024). Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization. Analytical Chemistry, 96 (22), 8893-9304. [BibTeX]
- Karlsson, J. , Lopez-Sanchez, P. , Marques, T. M. , Hyötyläinen, T. , Castro Alves, V. , Krona, A. & Ström, A. (2024). Effect of heating of pea fibres on their swelling, rheological properties and in vitro colon fermentation. Food Hydrocolloids, 147. [BibTeX]
- Salihovic, S. , Eklund, D. , Kruse, R. , Wallgren, U. , Hyötyläinen, T. , Särndahl, E. & Kurland, L. (2024). Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance. Metabolomics, 20 (5). [BibTeX]
- Sen, P. , Fan, Y. , Schlezinger, J. J. , Ehrlich, S. D. , Webster, T. F. , Hyötyläinen, T. , Pedersen, O. & Oresic, M. (2024). Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity. Environment International, 186. [BibTeX]
- Salihovic, S. , Nyström, N. , Mathisen, C. B. , Kruse, R. , Olbjørn, C. , Andersen, S. , Noble, A. J. , Dorn-Rasmussen, M. & et al. (2024). Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease. Nature Communications, 15 (1). [BibTeX]
- Hyötyläinen, T. , Ghaffarzadegan, T. , Karthikeyan, B. S. , Triplett, E. , Oresic, M. & Ludvigsson, J. (2024). Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases. Environmental Science and Technology, 58 (5), 2214-2223. [BibTeX]
- Hyötyläinen, T. , McGlinchey, A. J. , Salihovic, S. , Schubert, A. , Douglas, A. , Hay, D. C. , O'Shaughnessy, P. J. , Iredale, J. P. & et al. (2024). In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study. The Lancet Planetary Health, 8 (1), e5-e17. [BibTeX]
- Ahrens, A. P. , Hyötyläinen, T. , Petrone, J. R. , Igelström, K. , George, C. D. , Garrett, T. J. , Oresic, M. , Triplett, E. W. & et al. (2024). Infant microbes and metabolites point to childhood neurodevelopmental disorders. Cell, 187 (8), 1853-1873.e15. [BibTeX]
- Alijagic, A. , Sinisalu, L. , Duberg, D. , Kotlyar, O. , Scherbak, N. , Engwall, M. , Oresic, M. & Hyötyläinen, T. (2024). Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models. Environment International, 190. [BibTeX]
- Rotander, A. , Ramos, M. J. G. , Mueller, J. F. , Toms, L. & Hyötyläinen, T. (2024). Metabolic changes associated with PFAS exposure in firefighters: A pilot study. Science of the Total Environment, 935. [BibTeX]
- Latif Ali, M. , Ferrieres, L. , Jass, J. & Hyötyläinen, T. (2024). Metabolic Changes in Pseudomonas oleovorans Isolated from Contaminated Construction Material Exposed to Varied Biocide Treatments. Metabolites, 14 (6). [BibTeX]
- Karlsson, J. , Lopez-Sanchez, P. , Marques, T. M. , Hyötyläinen, T. , Castro Alves, V. , Krona, A. & Ström, A. (2024). Physico-chemical properties of pea fibre and pea protein blends and the implications for in vitro batch fermentation using human inoculum. Food Hydrocolloids, 150. [BibTeX]
- Bagavathy Shanmugam, K. , Hyötyläinen, T. , Ghaffarzadegan, T. , Triplett, E. , Oresic, M. & Ludvigsson, J. (2024). Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases. Journal of Exposure Science and Environmental Epidemiology, 34 (4), 647-658. [BibTeX]
- Thomas, I. , Newcombe, V. F. J. , Dickens, A. M. , Richter, S. , Posti, J. P. , Maas, A. I. R. , Tenovuo, O. , Hyötyläinen, T. & et al. (2024). Serum lipidome associates with neuroimaging features in patients with traumatic brain injury. iScience, 27 (9). [BibTeX]
- Alijagic, A. , Scherbak, N. , Kotlyar, O. , Karlsson, P. , Wang, X. , Odnevall, I. , Benada, O. , Amiryousefi, A. & et al. (2023). A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles. Cells, 12 (2). [BibTeX]
- Hylén, U. , Särndahl, E. , Bejerot, S. , Humble, M. B. , Hyötyläinen, T. , Salihovic, S. & Eklund, D. (2023). Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders. BMC Psychiatry, 23 (1). [BibTeX]
- Laudette, M. , Lindbom, M. , Arif, M. , Cinato, M. , Ruiz, M. , Doran, S. , Miljanovic, A. , Rutberg, M. & et al. (2023). Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function. Cardiovascular Research, 119 (7), 1537-1552. [BibTeX]
- Lamichhane, S. , Sen, P. , Dickens, A. M. , Kråkström, M. , Ilonen, J. , Lempainen, J. , Hyöty, H. , Lahesmaa, R. & et al. (2023). Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children. Frontiers in Endocrinology, 14. [BibTeX]
- Hyötyläinen, T. , Bagavathy Shanmugam, K. , Ghaffarzadegan, T. , Triplett, E. W. , Oresic, M. & Ludvigsson, J. (2023). Cord serum metabolic signatures of future progression to immune-mediated diseases. iScience, 26 (3). [BibTeX]
- Kråkström, M. , Dickens, A. M. , Alves, M. A. , Forssten, S. D. , Ouwehand, A. C. , Hyötyläinen, T. , Oresic, M. & Lamichhane, S. (2023). Dynamics of the Lipidome in a Colon Simulator. Metabolites, 13 (3). [BibTeX]
- Seeburger, P. , Forsman, H. , Bevilacqua, G. , Marques, T. M. , Morales, L. O. , Prado, S. B. R. , Strid, Å. , Hyötyläinen, T. & et al. (2023). From farm to fork… and beyond! UV enhances Aryl hydrocarbon receptor-mediated activity of cruciferous vegetables in human intestinal cells upon colonic fermentation. Food Chemistry, 426. [BibTeX]
- Lamichhane, S. , Härkönen, T. , Vatanen, T. , Hyötyläinen, T. , Knip, M. & Oresic, M. (2023). Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads. Environment International, 176. [BibTeX]
- Fan, Y. , Støving, R. K. , Berreira Ibraim, S. , Hyötyläinen, T. , Thirion, F. , Arora, T. , Lyu, L. , Stankevic, E. & et al. (2023). The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice. Nature Microbiology, 8 (5), 787-802. [BibTeX]
- Sommer, S. G. , Castro Alves, V. , Hyötyläinen, T. , Strid, Å. & Rosenqvist, E. (2023). The light spectrum differentially influences morphology, physiology and metabolism of Chrysanthemum × morifolium without affecting biomass accumulation. Physiologia Plantarum, 175 (6). [BibTeX]
- Seeburger, P. , Herdenstam, A. P. F. , Kurtser, P. , Arunachalam, A. , Castro Alves, V. , Hyötyläinen, T. & Andreasson, H. (2022). Controlled mechanical stimuli reveal novel associations between basil metabolism and sensory quality. Food Chemistry, 404 (Pt A). [BibTeX]
- Lamichhane, S. , Sen, P. , Dickens, A. M. , Alves, M. A. , Härkönen, T. , Honkanen, J. , Vatanen, T. , Xavier, R. J. & et al. (2022). Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes. Cell Reports Medicine, 3 (10). [BibTeX]
- Sen, P. , Qadri, S. , Luukkonen, P. K. , Ragnarsdottir, O. , McGlinchey, A. J. , Jäntti, S. , Juuti, A. , Arola, J. & et al. (2022). Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. Journal of Hepatology, 76 (2), 283-293. [BibTeX]
- Sinioja, T. , Bodin, J. , Duberg, D. , Dirven, H. , Berntsen, H. F. , Zimmer, K. , Nygaard, U. C. , Oresic, M. & et al. (2022). Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice. Metabolomics, 18 (11). [BibTeX]
- Lamichhane, S. , Siljander, H. , Salonen, M. , Ruohtula, T. , Virtanen, S. M. , Ilonen, J. , Hyötyläinen, T. , Knip, M. & et al. (2022). Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life. Frontiers in Nutrition, 9. [BibTeX]
- Lützhøft, D. O. , Sinioja, T. , Christoffersen, B. Ø. , Jakobsen, R. R. , Geng, D. , Ahmad, H. F. B. , Straarup, E. M. , Pedersen, K. & et al. (2022). Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model. BMC Microbiology, 22 (1). [BibTeX]
- Palma, C. F. F. , Castro Alves, V. , Morales, L. O. , Rosenqvist, E. , Ottosen, C. , Hyötyläinen, T. & Strid, Å. (2022). Metabolic changes in cucumber leaves are enhanced by blue light and differentially affected by UV interactions with light signalling pathways in the visible spectrum. Plant Science, 321. [BibTeX]
- McGlinchey, A. J. , Govaere, O. , Geng, D. , Ratziu, V. , Allison, M. , Bousier, J. , Petta, S. , de Oliviera, C. & et al. (2022). Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease. JHEP Reports, 4 (5). [BibTeX]
- Yin, X. , Mongan, D. , Cannon, M. , Zammit, S. , Hyötyläinen, T. , Oresic, M. , Brennan, L. & Cotter, D. R. (2022). Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort. Schizophrenia Research, 243, 78-85. [BibTeX]
- Sen, P. , Govaere, O. , Sinioja, T. , McGlinchey, A. J. , Geng, D. , Ratziu, V. , Bugianesi, E. , Schattenberg, J. M. & et al. (2022). Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease. iScience, 25 (9). [BibTeX]
- Thomas, I. , Dickens, A. M. , Posti, J. P. , Czeiter, E. , Duberg, D. , Sinioja, T. , Kråkström, M. , Retel Helmrich, I. R. A. & et al. (2022). Serum metabolome associated with severity of acute traumatic brain injury. Nature Communications, 13 (1). [BibTeX]
- Lahelma, M. , Qadri, S. , Ahlholm, N. , Porthan, K. , Ruuth, M. , Juuti, A. , Oresic, M. , Hyötyläinen, T. & et al. (2022). The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles. Atherosclerosis, 363, 22-29. [BibTeX]
- Sen, P. , Hyötyläinen, T. & Oresic, M. (2021). 1-Deoxyceramides: key players in lipotoxicity and progression to type 2 diabetes?. Acta Physiologica, 232 (1). [BibTeX]
- Karpale, M. , Käräjämäki, A. J. , Kummu, O. , Gylling, H. , Hyötyläinen, T. , Oresic, M. , Tolonen, A. , Hautajärvi, H. & et al. (2021). Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2-mediated mechanism. British Journal of Pharmacology, 178 (12), 2461-2481. [BibTeX]
- Rodriguez-Cuenca, S. , Lelliot, C. J. , Campbell, M. , Peddinti, G. , Martinez-Uña, M. , Ingvorsen, C. , Dias, A. R. , Relat, J. & et al. (2021). Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects. The FASEB Journal, 35 (9). [BibTeX]
- Blanc, M. , Alfonso, S. , Begout, M. , Barrachina, C. , Hyötyläinen, T. , Keiter, S. H. & Cousin, X. (2021). An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring. Science of the Total Environment, 754. [BibTeX]
- Hyötyläinen, T. (2021). Analytical challenges in human exposome analysis with focus on environmental analysis combined with metabolomics. Journal of Separation Science, 44 (8), 1769-1787. [BibTeX]
- Lamichhane, S. , Dickens, A. M. , Sen, P. , Laurikainen, H. , Borgan, F. , Suvisaari, J. , Hyötyläinen, T. , Howes, O. & et al. (2021). Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis. Schizophrenia Bulletin, 47 (1), 160-169. [BibTeX]
- Petersen, A. Ø. , Julienne, H. , Hyötyläinen, T. , Sen, P. , Fan, Y. , Pedersen, H. K. , Jäntti, S. , Hansen, T. H. & et al. (2021). Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species. Scientific Reports, 11 (1). [BibTeX]
- Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , de Vos, W. M. & et al. (2021). Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome. Beneficial Microbes, 12 (1), 17-30. [BibTeX]
- Kurtser, P. , Castro Alves, V. , Arunachalam, A. , Sjöberg, V. , Hanell, U. , Hyötyläinen, T. & Andreasson, H. (2021). Development of novel robotic platforms for mechanical stress induction, and their effects on plant morphology, elements, and metabolism. Scientific Reports, 11 (1). [BibTeX]
- Selvaraj, E. A. , Mózes, F. E. , Ajmer Jayaswal, A. N. , Zafarmand, M. H. , Vali, Y. , Lee, J. A. , Levick, C. K. , Joseph Young, L. A. & et al. (2021). Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. Journal of Hepatology, 75 (4), 770-785. [BibTeX]
- Dickens, A. M. , Sen, P. , Kempton, M. J. , Barrantes-Vidal, N. , Iyegbe, C. , Nordentoft, M. , Pollak, T. , Riecher-Rössler, A. & et al. (2021). Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biological Psychiatry, 89 (3), 288-297. [BibTeX]
- Lamichhane, S. , Siljander, H. , Duberg, D. , Honkanen, J. , Virtanen, S. M. , Oresic, M. , Knip, M. & Hyötyläinen, T. (2021). Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk. Environment International, 157. [BibTeX]
- Andersson, L. , Cinato, M. , Mardani, I. , Miljanovic, A. , Arif, M. , Koh, A. , Lindbom, M. , Laudette, M. & et al. (2021). Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking. European Heart Journal, 42 (43), 4481-4492. [BibTeX]
- Brial, F. , Chilloux, J. , Nielsen, T. , Vieira-Silva, S. , Falony, G. , Andrikopoulos, P. , Olanipekun, M. , Hoyles, L. & et al. (2021). Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. Gut, 70 (11), 2105-2114. [BibTeX]
- Castro Alves, V. , Kalbina, I. , Nilsen, A. , Mats, A. , Rosenqvist, E. , Jansen, M. A. K. , Qian, M. , Öström, Å. & et al. (2021). Integration of non-target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality: A case study using dill (Anethum graveolens). Food Chemistry, 344. [BibTeX]
- Lamichhane, S. , Sen, P. , Alves, M. A. , Ribeiro, H. C. , Raunioniemi, P. , Hyötyläinen, T. & Oresic, M. (2021). Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations. Metabolites, 11 (1). [BibTeX]
- Hyötyläinen, T. , Bodin, J. , Duberg, D. , Dirven, H. , Nygaard, U. C. & Oresic, M. (2021). Lipidomic Analyses Reveal Modulation of Lipid Metabolism by the PFAS Perfluoroundecanoic Acid (PFUnDA) in Non-Obese Diabetic Mice. Frontiers in Genetics, 12. [BibTeX]
- Lanzon, B. , Martin-Taboada, M. , Castro Alves, V. , Vila-Bedmar, R. , González de Pablos, I. , Duberg, D. , Gomez, P. , Rodriguez, E. & et al. (2021). Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity. Metabolites, 11 (12). [BibTeX]
- Ruuth, M. , Lahelma, M. , Luukkonen, P. K. , Lorey, M. B. , Qadri, S. , Sädevirta, S. , Hyötyläinen, T. , Kovanen, P. T. & et al. (2021). Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins. Arteriosclerosis, Thrombosis and Vascular Biology, 41 (11), 2823-2836. [BibTeX]
- Fart, F. , Salihovic, S. , McGlinchey, A. J. , Gareau, M. G. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T. & Schoultz, I. (2021). Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects ex vivo in murine intestinal tissue. Scandinavian Journal of Gastroenterology, 56 (11), 1286-1295. [BibTeX]
- Schlezinger, J. J. , Hyötyläinen, T. , Sinioja, T. , Boston, C. , Puckett, H. , Oliver, J. , Heiger-Bernays, W. & Webster, T. F. (2021). Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPAR α mice fed an American diet. Toxicology and Applied Pharmacology, 426. [BibTeX]
- Jendle, J. , Hyötyläinen, T. , Oresic, M. & Nyström, T. (2021). Pharmacometabolomic profiles in type 2 diabetic subjects treated with liraglutide or glimepiride. Cardiovascular Diabetology, 20 (1). [BibTeX]
- Hylén, U. , McGlinchey, A. J. , Oresic, M. , Bejerot, S. , Humble, M. B. , Särndahl, E. , Hyötyläinen, T. & Eklund, D. (2021). Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness. Frontiers in Psychiatry, 12. [BibTeX]
- Sinisalu, L. , Yeung, L. W. Y. , Wang, J. , Pan, Y. , Dai, J. & Hyötyläinen, T. (2021). Prenatal exposure to poly-/per-fluoroalkyl substances is associated with alteration of lipid profiles in cord-blood. Metabolomics, 17 (12). [BibTeX]
- Sen, P. , Andrabi, S. B. A. , Buchacher, T. , Khan, M. M. , Kalim, U. U. , Lindeman, T. M. , Alves, M. A. , Hinkkanen, V. & et al. (2021). Quantitative genome-scale metabolic modeling of human CD4+ T cell differentiation reveals subset-specific regulation of glycosphingolipid pathways. Cell Reports, 37 (6). [BibTeX]
- Salonurmi, T. , Nabil, H. , Ronkainen, J. , Hyötyläinen, T. , Hautajärvi, H. , Savolainen, M. J. , Tolonen, A. , Oresic, M. & et al. (2020). 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.. Frontiers in Pharmacology, 11. [BibTeX]
- Sinisalu, L. , Sen, P. , Salihovic, S. , Virtanen, S. M. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R. & et al. (2020). Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease. Environmental Research, 188. [BibTeX]
- Djekic, D. , Shi, L. , Calais, F. , Carlsson, F. , Landberg, R. , Hyötyläinen, T. & Fröbert, O. (2020). Effects of a Lacto-Ovo-Vegetarian Diet on the Plasma Lipidome and Its Association with Atherosclerotic Burden in Patients with Coronary Artery Disease-A Randomized, Open-Label, Cross-over Study. Nutrients, 12 (11). [BibTeX]
- Luukkonen, P. K. , Tukiainen, T. , Juuti, A. , Sammalkorpi, H. , Haridas, P. A. N. , Niemelä, O. , Arola, J. , Orho-Melander, M. & et al. (2020). Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight, 5 (5). [BibTeX]
- Thomas, I. , Dickens, A. M. , Posti, J. P. , Mohammadian, M. , Ledig, C. , Takala, R. S. K. , Hyötyläinen, T. , Tenovuo, O. & et al. (2020). Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury. International Journal of Molecular Sciences, 21 (4). [BibTeX]
- Dickens, A. M. , Borgan, F. , Laurikainen, H. , Lamichhane, S. , Marques, T. , Rönkkö, T. , Veronese, M. , Lindeman, T. & et al. (2020). Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis. NPJ schizophrenia, 6 (1). [BibTeX]
- Luukkonen, P. K. , Juuti, A. , Sammalkorpi, H. , Penttilä, A. K. , Oresic, M. , Hyötyläinen, T. , Arola, J. , Orho-Melander, M. & et al. (2020). MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology, 73 (3), 725-726. [BibTeX]
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- Moravcová, D. , Haapala, M. , Planeta, J. , Hyötyläinen, T. , Kostiainen, R. & Wiedmer, S. K. (2014). Separation of nucleobases, nucleosides, and nucleotides using two zwitterionic silica-based monolithic capillary columns coupled with tandem mass spectrometry. Journal of Chromatography A, 1373, 90-96. [BibTeX]
- Greiner, T. U. , Hyötyläinen, T. , Knip, M. , Bäckhed, F. & Oresic, M. (2014). The gut microbiota modulates glycaemic control and serum metabolite profiles in non-obese diabetic mice. PLOS ONE, 9 (11). [BibTeX]
- Nygren, H. , Pöhö, P. , Seppänen-Laakso, T. , Lahtinen, U. , Oresic, M. & Hyötyläinen, T. (2014). Ultrahigh-performance liquid chromatography-mass spectrometry in Lipidomics. LC GC North America, 32 (4), 286-293. [BibTeX]
- Hartonen, M. , Mattila, I. , Ruskeepää, A. , Oresic, M. & Hyötyläinen, T. (2013). Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. Journal of Chromatography A, 1293, 142-149. [BibTeX]
- Aura, A. , Mattila, I. , Hyötyläinen, T. , Gopalacharyulu, P. , Cheynier, V. , Souquet, J. , Bes, M. , Le Bourvellec, C. & et al. (2013). Characterization of microbial metabolism of Syrah grape products in an in vitro colon model using targeted and non-targeted analytical approaches. European Journal of Nutrition, 52 (2), 833-846. [BibTeX]
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- La Torre, D. , Seppänen-Laakso, T. , Larsson, H. E. , Hyötyläinen, T. , Ivarsson, S. A. , Lernmark, Å. & Oresic, M. (2013). Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes. Diabetes, 62 (11), 3951-3956. [BibTeX]
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- Kivilompolo, M. , Öhrnberg, L. , Oresic, M. & Hyötyläinen, T. (2013). Rapid quantitative analysis of carnitine and acylcarnitines by ultra-high performance-hydrophilic interaction liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1292, 189-194. [BibTeX]
- Jäntti, S. E. , Hartonen, M. , Hilvo, M. , Nygren, H. , Hyötyläinen, T. , Ketola, R. A. & Kostiainen, R. (2013). Steroid and steroid glucuronide profiles in urine during pregnancy determined by liquid chromatography-electrospray ionization-tandem mass spectrometry. Analytica Chimica Acta, 802, 56-66. [BibTeX]
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- Hyötyläinen, T. , Mattila, I. , Wiedmer, S. K. , Koivuniemi, A. , Taskinen, M. , Yki-Järvinen, H. & Oresic, M. (2012). Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance. Molecular Biosystems, 8 (10), 2559-2565. [BibTeX]
- Hyötyläinen, T. (2012). Novel methodologies in metabolic profiling with a focus on molecular diagnostic applications. Expert Review of Molecular Diagnostics, 12 (5), 527-538. [BibTeX]
- Oresic, M. , Seppänen-Laakso, T. , Sun, D. , Tang, J. , Therman, S. , Viehman, R. , Mustonen, U. , van Erp, T. G. & et al. (2012). Phospholipids and insulin resistance in psychosis: A lipidomics study of twin pairs discordant for schizophrenia. Genome Medicine, 4 (1). [BibTeX]
- Ketola, K. , Hilvo, M. , Hyötyläinen, T. , Vuoristo, A. , Ruskeepää, A. L. , Oresic, M. , Kallioniemi, O. P. & Iljin, K. (2012). Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. British Journal of Cancer, 106 (1), 99-106. [BibTeX]
- Pflueger, M. , Seppänen-Laakso, T. , Suortti, T. , Hyötyläinen, T. , Achenbach, P. , Bonifacio, E. , Oresic, M. & Ziegler, A. (2011). Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes. Diabetes, 60 (11), 2740-2747. [BibTeX]
- Pietiläinen, K. H. , Róg, T. , Seppänen-Laakso, T. , Virtue, S. , Gopalacharyulu, P. , Tang, J. , Rodriguez-Cuenca, S. , Maciejewski, A. & et al. (2011). Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS biology, 9 (6). [BibTeX]
- Castillo, S. , Mattila, I. , Miettinen, J. , Oresic, M. & Hyötyläinen, T. (2011). Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Analytical Chemistry, 83 (8), 3058-3067. [BibTeX]
- Aura, A. , Mattila, I. , Hyötyläinen, T. , Gopalacharyulu, P. , Bounsaythip, C. , Oresic, M. & Oksman-Caldentey, K. (2011). Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro. Molecular Biosystems, 7 (2), 437-446. [BibTeX]
- Götz, A. , Tyynismaa, H. , Euro, L. , Ellonen, P. , Hyötyläinen, T. , Ojala, T. , Hämäläinen, R. H. , Tommiska, J. & et al. (2011). Exome sequencing identifies mitochondrial alanyl-tRNA synthetase mutations in infantile mitochondrial cardiomyopathy. American Journal of Human Genetics, 88 (5), 635-642. [BibTeX]
- Nygren, H. , Seppänen-Laakso, T. , Castillo, S. , Hyötyläinen, T. & Oresic, M. (2011). Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods in Molecular Biology, 708, 247-257. [BibTeX]
- Orešič, M. , Hyötyläinen, T. , Herukka, S. , Sysi-Aho, M. , Mattila, I. , Seppänan-Laakso, T. , Julkunen, V. , Gopalacharyulu, P. V. & et al. (2011). Metabolome in progression to Alzheimer's disease. Translational Psychiatry, 1. [BibTeX]
- Oresic, M. , Tang, J. , Seppänen-Laakso, T. , Mattila, I. , Saarni, S. E. , Saarni, S. I. , Lönnqvist, J. , Sysi-Aho, M. & et al. (2011). Metabolome in schizophrenia and other psychotic disorders: a general population-based study. Genome Medicine, 3 (3). [BibTeX]
- Hilvo, M. , Denkert, C. , Lehtinen, L. , Müller, B. , Brockmöller, S. , Seppänen-Laakso, T. , Budczies, J. , Bucher, E. & et al. (2011). Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Research, 71 (9), 3236-45. [BibTeX]
- Pól, J. , Vidová, V. , Hyötyläinen, T. , Volný, M. , Novák, P. , Strohalm, M. , Kostiainen, R. , Havlíček, V. & et al. (2011). Spatial distribution of glycerophospholipids in the ocular lens. PLOS ONE, 6 (4). [BibTeX]
- Hyötyläinen, T. (2010). Analytical methodologies utilized in the search for chronic disease biomarkers. Bioanalysis, 2 (5), 919-923. [BibTeX]
- Helle, A. , Hirsjärvi, S. , Peltonen, L. , Hirvonen, J. , Wiedmer, S. K. & Hyötyläinen, T. (2010). Novel, dynamic on-line analytical separation system for dissolution of drugs from poly(lactic acid) nanoparticles. Journal of Pharmaceutical and Biomedical Analysis, 51 (1), 125-130. [BibTeX]
- Parshintsev, J. , Hyötyläinen, T. , Hartonen, K. , Kulmala, M. & Riekkola, M. -. (2010). Solid-phase extraction of organic compounds in atmospheric aerosol particles collected with the particle-into-liquid sampler and analysis by liquid chromatography-mass spectrometry. Talanta: The International Journal of Pure and Applied Analytical Chemistry, 80 (3), 1170-1176. [BibTeX]
Artiklar, forskningsöversikter
- Niarchos, G. , Alygizakis, N. , Carere, M. , Dulio, V. , Engwall, M. , Hyötyläinen, T. , Kallenborn, R. , Karakitsios, S. & et al. (2024). Pioneering an effect-based early warning system for hazardous chemicals in the environment. TrAC. Trends in analytical chemistry, 180. [BibTeX]
- Heuckeroth, S. , Damiani, T. , Smirnov, A. , Mokshyna, O. , Brungs, C. , Korf, A. , Smith, J. D. , Stincone, P. & et al. (2024). Reproducible mass spectrometry data processing and compound annotation in MZmine 3. Nature Protocols, 19 (9), 2597-2641. [BibTeX]
- Salihovic, S. , Lamichane, S. , Hyötyläinen, T. & Oresic, M. (2023). Recent advances towards mass spectrometry-based clinical lipidomics. Current opinion in chemical biology, 76. [BibTeX]
- Castro Alves, V. , Oresic, M. & Hyötyläinen, T. (2022). Lipidomics in nutrition research. Current opinion in clinical nutrition and metabolic care, 25 (5), 311-318. [BibTeX]
- Masoodi, M. , Gastaldelli, A. , Hyötyläinen, T. , Arretxe, E. , Alonso, C. , Gaggini, M. , Brosnan, J. , Anstee, Q. M. & et al. (2021). Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests. Nature Reviews. Gastroenterology & Hepatology, 18 (12), 835-856. [BibTeX]
- Alves, M. A. , Lamichhane, S. , Dickens, A. , McGlinchey, A. J. , Ribeiro, H. C. , Sen, P. , Wei, F. , Hyötyläinen, T. & et al. (2021). Systems biology approaches to study lipidomes in health and disease. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1866 (2). [BibTeX]
- Oresic, M. , McGlinchey, A. J. , Wheelock, C. E. & Hyötyläinen, T. (2020). Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health. Metabolites, 10 (11). [BibTeX]
- Fang, W. , Santosh, L. , Oresic, M. & Hyötyläinen, T. (2019). Lipidomes in health and disease: Analytical strategies and considerations. TrAC. Trends in analytical chemistry, 120. [BibTeX]
- Posti, J. P. , Dickens, A. M. , Orešič, M. , Hyötyläinen, T. & Tenovuo, O. (2017). Metabolomics Profiling As a Diagnostic Tool in Severe Traumatic Brain injury. Frontiers in Neurology, 8. [BibTeX]
- Hyötyläinen, T. & Oresic, M. (2015). Optimizing the lipidomics workflow for clinical studies: practical considerations. Analytical and Bioanalytical Chemistry, 407 (17), 4973-4993. [BibTeX]
- Hyötyläinen, T. & Oresic, M. (2014). Systems biology strategies to study lipidomes in health and disease. Progress in lipid research, 55 (1), 43-60. [BibTeX]
- Robciuc, A. , Hyötyläinen, T. , Jauhiainen, M. & Holopainen, J. M. (2013). Ceramides in the pathophysiology of the anterior segment of the eye. Current Eye Research, 38 (10), 1006-1016. [BibTeX]
- Hyötyläinen, T. , Bondia-Pons, I. & Oresic, M. (2013). Lipidomics in nutrition and food research. Molecular Nutrition & Food Research, 57 (8), 1306-1318. [BibTeX]
Kapitel i böcker, del av antologier
- Lamichhane, S. , Sen, P. , Dickens, A. M. , Hyötyläinen, T. & Orešič, M. (2018). An Overview of Metabolomics Data Analysis: Current Tools and Future Perspectives. I: Joaquim Jaumot; Carmen Bedia; Romà Tauler, Data Analysis for Omic Sciences: Methods and Applications (ss. 387-413). . Elsevier. [BibTeX]
Konferensbidrag
- Salihovic, S. , Nyström, N. , Mathisen, C. B. , Andersen, S. , Olbjørn, C. , Perminow, G. , Opheim, R. , Detlie, T. E. & et al. (2023). Identification and validation of a lipidomic signature as a novel diagnostic biomarker of paediatric Inflammatory Bowel Disease. I: Journal of Crohn's & Colitis. Oxford University Press. [BibTeX]
- Qadri, S. , Vartiainen, E. , Ahlholm, N. , Porthan, K. , Juuti, A. , Sammalkorpi, H. , Penttilä, A. , Arola, J. & et al. (2022). Hepatic insulin resistance is the basis of bile acid dysmetabolism in non-alcoholic fatty liver disease. I: Journal of Hepatology. Konferensbidrag vid The International Liver Congress 2022, London, UK, June 22-26, 2022. (ss. S694-S695). Elsevier. [BibTeX]
- Qadri, S. , Blom, S. , Pitkänen, K. , Ahlholm, N. , Porthan, K. , Luukkonen, P. K. , Juuti, A. , Sammalkorpi, H. & et al. (2022). Heterogeneity of phosphatidylcholine metabolism in nonalcoholic fatty liver disease. I: Journal of Hepatology. Konferensbidrag vid The International Liver Congress 2022, London, UK, June 22-26, 2022. (ss. S111-S111). Elsevier. [BibTeX]
- Oresic, M. , Sen, P. , Quadri, S. , Luukkonen, P. , Ragnarsdottir, O. , Jäntti, S. , Juuti, A. , Arola, J. & et al. (2021). Exposure to environmental contaminants is associated with sex-specific disturbances of hepatic lipid metabolism in non-alcoholic fatty liver disease. I: Journal of Hepatology. Konferensbidrag vid The International Liver Congress, (Digital congress), June 23–26, 2021. (ss. S605-S606). Elsevier. [BibTeX]
- Sen, P. , Govaere, O. , Sinioja, T. , McGlinchey, A. J. , Geng, D. , Ratziu, V. , Bugianesi, E. , Schattenberg, J. & et al. (2021). Genome-scale metabolic modeling of human hepatocytes reveals dysregulation of glycosphingolipid pathways in progressive non-alcoholic fatty liver disease. I: Journal of Hepatology. Konferensbidrag vid The International Liver Congress, (Digital congress), June 23–26, 2021. (ss. S256-S256). Elsevier. [BibTeX]
- Sen, P. , Andrabi, S. B. A. , Buchacher, T. , Khan, M. M. , Ullah, U. , Lindeman, T. M. , Alves, M. A. , Hinkkanen, V. & et al. (2021). Quantitative analysis of human CD4+T-cell differentiation reveals subset-specific regulation of glycosphingolipid pathways. I: European Journal of Immunology. Konferensbidrag vid 6th European Congress of Immunology, (Virtual meeting), September 1–4, 2021. (ss. 237-237). John Wiley & Sons. [BibTeX]
- Ha, V. T. , Lainscek, D. , Gesslbauer, B. , Jarc, E. , Hyötyläinen, T. , Ilc, N. , Lakota, K. , Tomsic, M. & et al. (2021). Synergy between 15-lipoxygenase and secreted PLA2 promotes inflammation by formation of TLR4 agonists from extracellular vesicles. I: FEBS Open Bio. Konferensbidrag vid 45th FEBS Congress, Molecules of Life: Towards New Horizons, Ljubljana, Slovenia, July 3–8, 2021. (ss. 480-480). John Wiley & Sons. [BibTeX]
- McGlinchey, A. J. , Geng, D. , Govaere, O. , Ratziu, V. , Bugianesi, E. , Schattenberg, J. M. , Daley, A. , Hyötyläinen, T. & et al. (2021). The Metabolomics of Non-Alcoholic Fatty Liver Disease: Of Networks and Biomarkers. I: Journal of Hepatology. Konferensbidrag vid The International Liver Congress, (Digital congress), June 23–26, 2021. (ss. S579-S580). Elsevier. [BibTeX]
- Sen, P. , Govaere, O. , McGlinchey, A. J. , Ratziu, V. , Bugianesi, E. , Schattenberg, J. M. , Allison, M. , Cockell, S. & et al. (2020). Metabolism of human liver on a genome scale in non-alcoholic fatty liver disease. I: Journal of Hepatology. Konferensbidrag vid The Digital International Liver Congress (EASL 2020), August 27-29, 2020. (ss. S671-S672). Elsevier. [BibTeX]
- McGlinchey, A. J. , Geng, D. , Govaere, O. , Ratziu, V. , Bugianesi, E. , Schattenberg, J. M. , Daly, A. K. , Hyötyläinen, T. & et al. (2020). Metabolomics approaches to identify biomarkers of nonalcoholic fatty liver disease. I: Journal of Hepatology. Konferensbidrag vid The Digital International Liver Congress (EASL 2020), August 27-29, 2020. (ss. S438-S438). Elsevier. [BibTeX]
- Fart, F. , Salihovic, S. , McGlinchey, A. J. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T. & Schoultz, I. (2020). Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis. I: Journal of Crohn's & Colitis. Oxford University Press. [BibTeX]
- Posti, J. P. , Dickens, A. , Takala, R. S. , Ala-Seppälä, H. , Mattila, I. , Coles, J. P. , Frantzén, J. , Hutchinson, P. J. & et al. (2018). SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY. I: Journal of Neurotrauma. Konferensbidrag vid 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, Toronto, Canada, August 11-16, 2018. (ss. A67-A67). Mary Ann Liebert. [BibTeX]
Manuskript
- Nilén, G. , Sunder, S. , Hyötyläinen, T. , Scherbak, N. & Keiter, S. A binary, ternary, and quaternary mixture of PFOS, B[a]P, PCB126, and Arsenic alters behavior, gene expression, and lipid content in zebrafish larvae (Danio rerio). [BibTeX]
- Blanc, M. , Alfonso, S. , Bégout, M. , Barrachina, C. , Hyötyläinen, T. , Keiter, S. & Cousin, X. An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in exposed zebrafish and their unexposed F2 offspring. [BibTeX]
- Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , De Vos, W. M. & et al. Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome. [BibTeX]
- Hylén, U. , Särndahl, E. , Bejerot, S. , Humble, M. B. , Hyötyläinen, T. , Eklund, D. & Salihovic, S. Elevated plasma levels of polyamines and kynurenines in individuals with psychiatric disorders. [BibTeX]
- Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Lindqvist, C. M. , de Vos, W. , Brummer, R. J. & König, J. Faecal microbiota transfer in irritable bowel syndrome results inaltered correlations between the gut microbiota and its metabolites. [BibTeX]
- Hylén, U. , Särndahl, E. , Bejerot, S. , Humble, M. B. , Hyötyläinen, T. & Salihovic, S. Individuals with severe psychiatric disorders display altered pattern of plasma immunometabolites. [BibTeX]
- Blanc, M. , Cormier, B. , Hyötyläinen, T. , Krauss, M. , Scherbak, N. , Cousin, X. & Keiter, S. Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47 : impact on growth, fertility, behavior and lipid metabolism. [BibTeX]