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Yvonne Freund Levi

Title: Senior Lecturer School/office: School of Medical Sciences

Email:

Phone: +46 19 302414, +46 736 841130

Room: C2101

Yvonne Freund Levi

Research subject

Research teams

Publications

Articles in journals |  Articles, reviews/surveys | 

Articles in journals

Tijms, B. M. , Gobom, J. , Teunissen, C. , Dobricic, V. , Tsolaki, M. , Verhey, F. , Popp, J. , Martinez-Lage, P. & et al. (2021). CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals. Proteomes, 9 (3).
Tofiq, A. , Zetterberg, H. , Blennow, K. , Basun, H. , Cederholm, T. , Eriksdotter, M. , Faxén-Irving, G. , Hjorth, E. & et al. (2021). Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study. Journal of Alzheimer's Disease, 83 (3), 1291-1301.
Zhai, Q. , Freund-Levi, Y. , Horn, A. , Fridenberger, A. -. , Lager, E. , Montgomery, S. & Persson, J. (2021). Physical training for patients with depression and anxiety - a randomized controlled study. European psychiatry, 64 (Suppl. 1), S690-S690.
Shi, L. , Freund-Levi, Y. & Nevado-Holgado, A. J. (2021). Replication study of plasma proteins relating to Alzheimer's pathology. Alzheimer's & Dementia.
Bloniecki, V. , Zetterberg, H. , Aarsland, D. , Vannini, P. , Kvartsberg, H. , Winblad, B. , Blennow, K. & Freund-Levi, y. (2020). Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?. Alzheimer's Research & Therapy, 12 (1).
Westwood, S. , Baird, A. L. , Anand, S. N. , Nevado-Holgado, A. J. , Kormilitzin, A. , Shi, L. , Hye, A. , Ashton, N. J. & et al. (2020). Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. Journal of Alzheimer's Disease, 74 (1), 213-225.
Stamate, D. , Kim, M. , Proitsi, P. , Weestwood, S. , Baird, A. , Nevado-Holgado, A. , Hye, A. , Bos, I. & et al. (2019). A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5 (C), 933-938.
van Maurik, I. S. , Vos, S. J. , Bos, I. , Bouwman, F. H. , Teunissen, C. E. , Scheltens, P. , Barkhof, F. , Frolich, L. & et al. (2019). Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study. Lancet Neurology, 18 (11), 1034-1044.
Bos, I. , Vos, S. , Verhey, F. , Scheltens, P. , Teunissen, C. , Engelborghs, S. , Sleegers, K. , Frisoni, G. & et al. (2019). Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum. Alzheimer's & Dementia, 15 (5), 644-654.
Vermunt, L. , Sikkes, S. A. M. , van den Hout, A. , Handels, R. , Bos, I. , van der Flier, W. M. , Kern, S. , Ousset, P. & et al. (2019). Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimer's & Dementia, 15 (7), 888-898.
Jernerén, F. , Cederholm, T. , Refsum, H. , Smith, A. D. , Turner, C. , Palmblad, J. , Eriksdotter, M. , Hjorth, E. & et al. (2019). Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study. Journal of Alzheimer's Disease, 69 (1), 189-197.
Lleó, A. , Alcolea, D. , Martínez-Lage, P. , Scheltens, P. , Parnetti, L. , Poirier, J. , Simonsen, A. H. , Verbeek, M. M. & et al. (2019). Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study. Alzheimer's & Dementia, 15 (6), 742-753.
Bos, I. , Vos, S. J. B. , Jansen, W. J. , Vandenberghe, R. , Gabel, S. , Estanga, A. , Ecay-Torres, M. , Tomassen, J. & et al. (2018). Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data.. Frontiers in Aging Neuroscience, 10.
Jansen, W. J. , Visser, P. J. , Amyloid Biomarker Study Group, . & Freund-Levi, Y. (2018). Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA psychiatry, 75 (1), 84-95.
Bos, I. , Verhey, F. R. , Ramakers, I. H. G. B. , Jacobs, H. I. L. , Soininen, H. , Freund-Levi, Y. , Hampel, H. , Tsolaki, M. & et al. (2018). Correction to: Cerebrovascular and amyloid pathology in predementia stages. Alzheimer's Research & Therapy, 10 (56).
Faxen-Irving, G. , Falahati, F. , Basun, H. , Eriksdotter, M. , Vedin, I. , Wahlund, L. , Schultzberg, M. , Hjorth, E. & et al. (2018). Does Fatty Acid Composition in Subcutaneous Adipose Tissue Differ between Patients with Alzheimer's Disease and Cohabiting Proxies?. Journal of Alzheimer's Disease, 61 (2), 515-519.
Mattsson, N. , Freund-Levi, Y. & Ossenkoppele, R. (2018). Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease. Alzheimer's & Dementia, 14 (7), 913-924.
Reijs, B. L. R. , Vos, S. J. B. , Soininen, H. , Lötjonen, J. , Koikkalainen, J. , Pikkarainen, M. , Hall, A. , Vanninen, R. & et al. (2017). Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. Journal of Alzheimer's Disease, 60 (4), 1387-1395.
Bos, I. , Verhey, F. R. , Ramakers, I. H. G. B. , Jacobs, H. I. L. , Soininen, H. , Freund-Levi, Y. , Hampel, H. , Tsolaki, M. & et al. (2017). Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimer's Research & Therapy, 9 (1).
Karimi, M. , Vedin, I. , Freund-Levi, Y. , Basun, H. , Faxén Irving, G. , Eriksdotter, M. , Wahlund, L. , Schultzberg, M. & et al. (2017). DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study. American Journal of Clinical Nutrition, 106 (4), 1157-1165.
Bloniecki, V. , Aarsland, D. , Blennow, K. , Cummings, J. , Falahati, F. , Winblad, B. & Freund-Levi, Y. (2017). Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid. Journal of Alzheimer's Disease, 57 (2), 387-393.
van Waalwijk van Doorn, L. J. C. , Freund-Levi, Y. & Verbeek, M. M. (2017). Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes. Journal of Alzheimer's Disease, 56 (2), 543-555.
Shlisky, J. , Bloom, D. E. , Beaudreault, A. R. , Tucker, K. L. , Keller, H. H. , Freund-Levi, Y. , Fielding, R. A. , Cheng, F. W. & et al. (2017). Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease. Advances in Nutrition, 8 (1), 17-26.
Handels, R. L. H. , Vos, S. J. B. , Kramberger, M. G. , Jelic, V. , Blennow, K. , van Buchem, M. , van der Flier, W. , Freund-Levi, Y. & et al. (2017). Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers. Alzheimer's & Dementia, 13 (8), 903-912.
Bos, I. , Vos, S. J. , Frölich, L. , Kornhuber, J. , Wiltfang, J. , Maier, W. , Peters, O. , Rüther, E. & et al. (2017). The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiology of Aging, 56, 33-40.
Wang, X. , Hjorth, E. , Vedin, I. , Eriksdotter, M. , Freund-Levi, Y. , Wahlund, L. , Cederholm, T. , Palmblad, J. & et al. (2015). Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study. Journal of Lipid Research, 56 (3), 674-681.
Eriksdotter, M. , Vedin, I. , Falahati, F. , Freund-Levi, Y. , Hjorth, E. , Faxen-Irving, G. , Wahlund, L. , Schultzberg, M. & et al. (2015). Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. Journal of Alzheimer's Disease, 48 (3), 805-812.
Hall, A. , Mattila, J. , Koikkalainen, J. , Lötjonen, J. , Wolz, R. , Scheltens, P. , Frisoni, G. , Tsolaki, M. & et al. (2015). Predicting progression from cognitive impairment to Alzheimer's disease with the Disease State Index. Current Alzheimer Research, 12 (1), 69-79.
Vos, S. J. B. , Verhey, F. , Frölich, L. , Kornhuber, J. , Wiltfang, J. , Maier, W. , Peters, O. , Rüther, E. & et al. (2015). Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage. Brain, 138 (5), 1327-1338.
Jansen, W. J. , Ossenkoppele, R. , Knol, D. L. , Tijms, B. M. , Scheltens, P. , Verhey, F. R. J. , Visser, P. J. , The Amyloid Biomarker Study Group, . & et al. (2015). Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. Journal of the American Medical Association (JAMA), 313 (19), 1924-1938.
Bloniecki, V. , Aarsland, D. , Cummings, J. , Blennow, K. & Freund-Levi, Y. (2014). Agitation in dementia: relation to core cerebrospinal fluid biomarker levels. Dementia and geriatric cognitive disorders extra, 4 (2), 335-43.
Freund-Levi, Y. , Vedin, I. , Hjorth, E. , Basun, H. , Faxén Irving, G. , Schultzberg, M. , Eriksdotter, M. , Palmblad, J. & et al. (2014). Effects of supplementation with omega-3 fatty acids on oxidative stress and inflammation in patients with Alzheimer's disease: the OmegAD study. Journal of Alzheimer's Disease, 42 (3), 823-831.
Freund-Levi, Y. , Bloniecki, V. , Auestad, B. , Tysen Bäckström, A. C. , Lärksäter, M. & Aarsland, D. (2014). Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study. Dementia and Geriatric Cognitive Disorders, 38 (3-4), 234-244.
Freund-Levi, Y. , Jedenius, E. , Tysen-Bäckström, A. C. , Lärksäter, M. , Wahlund, L. & Eriksdotter, M. (2014). Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial. The American journal of geriatric psychiatry, 22 (4), 341-248.
Holmgren, S. , Hjorth, E. , Schultzberg, M. , Lärksäter, M. , Frenkel, D. , Tysen-Bäckström, A. C. , Aarsland, D. & Freund-Levi, Y. (2014). Neuropsychiatric symptoms in dementia: a role for neuroinflammation?. Brain Research Bulletin, 108, 88-93.
Freund-Levi, Y. , Jedenius, E. , Wahlund, L. , Eriksdotter, M. , Tysen-Bäckström, A. C. & Lärksäter, M. (2014). Response to Bogaiksy's Letter to the Editor. The American journal of geriatric psychiatry, 22 (9), 951-951.
Freund-Levi, Y. , Vedin, I. , Cederholm, T. , Basun, H. , Faxén Irving, G. , Eriksdotter, M. , Hjorth, E. , Schultzberg, M. & et al. (2014). Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. Journal of Internal Medicine, 275 (4), 428-436.
Faxén-Irving, G. , Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Basun, H. , Hjorth, E. , Palmblad, J. , Vedin, I. , Cederholm, T. & et al. (2013). Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. Journal of Alzheimer's Disease, 36 (1), 1-6.
Forsberg, A. , Juréus, A. , Cselényi, Z. , Eriksdotter, M. , Freund-Levi, Y. , Jeppsson, F. , Swahn, B. , Sandell, J. & et al. (2013). Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients. European Journal of Nuclear Medicine and Molecular Imaging, 40 (4), 580-593.
Hjorth, E. , Zhu, M. , Toro, V. C. , Vedin, I. , Palmblad, J. , Cederholm, T. , Freund-Levi, Y. , Faxen-Irving, G. & et al. (2013). Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. Journal of Alzheimer's Disease, 35 (4), 697-713.
Bloniecki, V. , Freund-Levi, Y. , Aarsland, D. & Blennow, K. (2012). Agitation - relation to clinical and dementia biomarkers in cerebrospinal fluid. European Journal of Neurology, 19 (s1), 112-112.
Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Garlind, A. , Irving, G. F. , Eriksdotter-Jönhagen, M. , Wahlund, L. & et al. (2012). Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLOS ONE, 7 (4).
Hjorth, E. & Freund-Levi, Y. (2012). Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid.. Current opinion in clinical nutrition and metabolic care, 15 (2), 134-143.
Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Hjorth, E. , Faxén Irving, G. , Eriksdotter-Jönhagen, M. , Schultzberg, M. & et al. (2010). Reduced prostaglandin F-2 alpha release from blood mononuclear leukocytes after oral supplementation of omega 3 fatty acids: the OmegAD study. Journal of Lipid Research, 51 (5), 1179-1185.
Fjellström, C. , Starkenberg, Å. , Wesslén, A. , Tysén Bäckstrom, A. , Faxén-Irving, G. , The OmegAD Study group, . & Freund-Levi, Y. (2010). To Be a Good Food Provider: An Exploratory Study Among Spouses of Persons With Alzheimer's Disease. American Journal of Alzheimer’s Disease and Other Dementia, 25 (6), 521-526.
Nyberg, S. , Eriksdotter Jönhagen, M. , Cselényi, Z. , Halldin, C. , Julin, P. , Olsson, H. , Freund-Levi, Y. , Andersson, J. & et al. (2009). Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184. European Journal of Nuclear Medicine and Molecular Imaging, 36 (11), 1859-1863.
Freund-Levi, Y. , Hjorth, E. , Lindberg, C. , Cederholm, T. , Faxen-Irving, G. , Vedin, I. , Palmblad, J. , Wahlund, L. & et al. (2009). Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study. Dementia and Geriatric Cognitive Disorders, 27 (5), 481-490.
Irving, G. F. , Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Basun, H. , Brismar, K. , Hjorth, E. , Palmblad, J. , Vessby, B. & et al. (2009). Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. Journal of The American Geriatrics Society, 57 (1), 11-17.
Visser, P. J. , Verhey, F. , Knol, D. L. , Scheltens, P. , Wahlund, L. , Freund-Levi, Y. , Tsolaki, M. , Minthon, L. & et al. (2009). Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurology, 8 (7), 619-627.
Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Garlind, A. , Faxén Irving, G. , Jönhagen, M. E. , Vessby, B. & et al. (2008). Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. American Journal of Clinical Nutrition, 87 (6), 1616-1622.
Freund-Levi, Y. , Basun, H. , Cederholm, T. , Faxén-Irving, G. , Garlind, A. , Grut, M. , Vedin, I. , Palmblad, J. & et al. (2008). Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms. International Journal of Geriatric Psychiatry, 23 (2), 161-169.
Palmblad, J. , Eriksdotter-Jönhagen, M. , Freund-Levi, Y. & Cederholm, T. (2007). [Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited]. Läkartidningen, 104 (44), 3268-3271.
Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Cederholm, T. , Basun, H. , Faxén-Irving, G. , Garlind, A. , Vedin, I. , Vessby, B. & et al. (2006). Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study - A randomized double-blind trial. Archives of Neurology, 63 (10), 1402-1408.
Nordberg, A. , Eriksdotter-Jönhagen, M. , Garlind, A. , Grut, M. , Freund-Levi, Y. , Cornelius, C. , Ekström, A. , Fastbom, J. & et al. (2006). Värt ge symtomlindrande läkemedel vid Alzheimers sjukdom [Administration of symptom-relieving drugs in Alzheimer disease is beneficial]. Läkartidningen, 103 (6), 369-371.
Vedin, I. , Cederholm, T. , Liden, J. , Freund-Levi, Y. , Palmblad, J. & OmegAD, S. G. (2004). Inflammatory gene expression changes by omega-3 fatty acids in patients with Alzheimer's disease. The FASEB Journal, 18 (4), A501-A501.
Freund-Levi, Y. , Jonhagen, M. , Wahlund, L. , Basun, H. , Palmblad, J. & Cederholm, T. (2004). Safety and tolerability of omega-3 fatty acids in patients with Alzheimer's disease. Neurobiology of Aging, 25 (Supplement 2), S471-S471.

Articles, reviews/surveys

Bateman, D. R. , Sascha, G. , Hu, S. , Foster, E. D. , Ruthirakuhan, M. T. , Sellek, A. F. , Mortby, M. E. , Matušková, V. & et al. (2020). Agitation and impulsivity in mid and late life as possible riskmarkers for incident dementia. Alzheimer's & Dementia, 6 (1).