This page in English

Yvonne Freund Levi

Tjänstetitel: Universitetslektor Organisation: Institutionen för medicinska vetenskaper

E-post:

Telefon: 019 302414, 0736 841130

Rum: C2101

Yvonne Freund Levi

Forskningsämne

Om Yvonne Freund Levi

Yvonne Freund-Levi är nytillträdd lektor i klinisk neurovetenskap vid Örebro universitet, överläkare i psykiatri i Region Örebro samt docent på KI. Hon är psykiatriker och geriatriker, kognitiv psykoterapeut och mindfulnessinstruktör, och har haft flera chefspositioner.

Nya modeller kan räkna fram mer exakt risk för demens

https://karriarlakare.se/artikel/chefens-tips-gor-annat/

B-vitaminer påverkar positiv effekt av Omega-3 för människor med Alzheimers sjukdom

 

Forskargrupper

Publikationer

Artiklar i tidskrifter |  Artiklar, forskningsöversikter | 

Artiklar i tidskrifter

Tijms, B. M. , Gobom, J. , Teunissen, C. , Dobricic, V. , Tsolaki, M. , Verhey, F. , Popp, J. , Martinez-Lage, P. & et al. (2021). CSF Proteomic Alzheimer's Disease-Predictive Subtypes in Cognitively Intact Amyloid Negative Individuals. Proteomes, 9 (3).
Tofiq, A. , Zetterberg, H. , Blennow, K. , Basun, H. , Cederholm, T. , Eriksdotter, M. , Faxén-Irving, G. , Hjorth, E. & et al. (2021). Effects of Peroral Omega-3 Fatty Acid Supplementation on Cerebrospinal Fluid Biomarkers in Patients with Alzheimer's Disease: A Randomized Controlled Trial-The OmegAD Study. Journal of Alzheimer's Disease, 83 (3), 1291-1301.
Zhai, Q. , Freund-Levi, Y. , Horn, A. , Fridenberger, A. -. , Lager, E. , Montgomery, S. & Persson, J. (2021). Physical training for patients with depression and anxiety - a randomized controlled study. European psychiatry, 64 (Suppl. 1), S690-S690.
Shi, L. , Freund-Levi, Y. & Nevado-Holgado, A. J. (2021). Replication study of plasma proteins relating to Alzheimer's pathology. Alzheimer's & Dementia.
Bloniecki, V. , Zetterberg, H. , Aarsland, D. , Vannini, P. , Kvartsberg, H. , Winblad, B. , Blennow, K. & Freund-Levi, y. (2020). Are neuropsychiatric symptoms in dementia linked to CSF biomarkers of synaptic and axonal degeneration?. Alzheimer's Research & Therapy, 12 (1).
Westwood, S. , Baird, A. L. , Anand, S. N. , Nevado-Holgado, A. J. , Kormilitzin, A. , Shi, L. , Hye, A. , Ashton, N. J. & et al. (2020). Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. Journal of Alzheimer's Disease, 74 (1), 213-225.
Stamate, D. , Kim, M. , Proitsi, P. , Weestwood, S. , Baird, A. , Nevado-Holgado, A. , Hye, A. , Bos, I. & et al. (2019). A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 5 (C), 933-938.
van Maurik, I. S. , Vos, S. J. , Bos, I. , Bouwman, F. H. , Teunissen, C. E. , Scheltens, P. , Barkhof, F. , Frolich, L. & et al. (2019). Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study. Lancet Neurology, 18 (11), 1034-1044.
Bos, I. , Vos, S. , Verhey, F. , Scheltens, P. , Teunissen, C. , Engelborghs, S. , Sleegers, K. , Frisoni, G. & et al. (2019). Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum. Alzheimer's & Dementia, 15 (5), 644-654.
Vermunt, L. , Sikkes, S. A. M. , van den Hout, A. , Handels, R. , Bos, I. , van der Flier, W. M. , Kern, S. , Ousset, P. & et al. (2019). Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Alzheimer's & Dementia, 15 (7), 888-898.
Jernerén, F. , Cederholm, T. , Refsum, H. , Smith, A. D. , Turner, C. , Palmblad, J. , Eriksdotter, M. , Hjorth, E. & et al. (2019). Homocysteine Status Modifies the Treatment Effect of Omega-3 Fatty Acids on Cognition in a Randomized Clinical Trial in Mild to Moderate Alzheimer's Disease: The OmegAD Study. Journal of Alzheimer's Disease, 69 (1), 189-197.
Lleó, A. , Alcolea, D. , Martínez-Lage, P. , Scheltens, P. , Parnetti, L. , Poirier, J. , Simonsen, A. H. , Verbeek, M. M. & et al. (2019). Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study. Alzheimer's & Dementia, 15 (6), 742-753.
Bos, I. , Vos, S. J. B. , Jansen, W. J. , Vandenberghe, R. , Gabel, S. , Estanga, A. , Ecay-Torres, M. , Tomassen, J. & et al. (2018). Amyloid-β, Tau, and Cognition in Cognitively Normal Older Individuals: Examining the Necessity to Adjust for Biomarker Status in Normative Data.. Frontiers in Aging Neuroscience, 10.
Jansen, W. J. , Visser, P. J. , Amyloid Biomarker Study Group, . & Freund-Levi, Y. (2018). Association of Cerebral Amyloid-β Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA psychiatry, 75 (1), 84-95.
Bos, I. , Verhey, F. R. , Ramakers, I. H. G. B. , Jacobs, H. I. L. , Soininen, H. , Freund-Levi, Y. , Hampel, H. , Tsolaki, M. & et al. (2018). Correction to: Cerebrovascular and amyloid pathology in predementia stages. Alzheimer's Research & Therapy, 10 (56).
Faxen-Irving, G. , Falahati, F. , Basun, H. , Eriksdotter, M. , Vedin, I. , Wahlund, L. , Schultzberg, M. , Hjorth, E. & et al. (2018). Does Fatty Acid Composition in Subcutaneous Adipose Tissue Differ between Patients with Alzheimer's Disease and Cohabiting Proxies?. Journal of Alzheimer's Disease, 61 (2), 515-519.
Mattsson, N. , Freund-Levi, Y. & Ossenkoppele, R. (2018). Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease. Alzheimer's & Dementia, 14 (7), 913-924.
Reijs, B. L. R. , Vos, S. J. B. , Soininen, H. , Lötjonen, J. , Koikkalainen, J. , Pikkarainen, M. , Hall, A. , Vanninen, R. & et al. (2017). Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. Journal of Alzheimer's Disease, 60 (4), 1387-1395.
Bos, I. , Verhey, F. R. , Ramakers, I. H. G. B. , Jacobs, H. I. L. , Soininen, H. , Freund-Levi, Y. , Hampel, H. , Tsolaki, M. & et al. (2017). Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimer's Research & Therapy, 9 (1).
Karimi, M. , Vedin, I. , Freund-Levi, Y. , Basun, H. , Faxén Irving, G. , Eriksdotter, M. , Wahlund, L. , Schultzberg, M. & et al. (2017). DHA-rich n-3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study. American Journal of Clinical Nutrition, 106 (4), 1157-1165.
Bloniecki, V. , Aarsland, D. , Blennow, K. , Cummings, J. , Falahati, F. , Winblad, B. & Freund-Levi, Y. (2017). Effects of Risperidone and Galantamine Treatment on Alzheimer's Disease Biomarker Levels in Cerebrospinal Fluid. Journal of Alzheimer's Disease, 57 (2), 387-393.
van Waalwijk van Doorn, L. J. C. , Freund-Levi, Y. & Verbeek, M. M. (2017). Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes. Journal of Alzheimer's Disease, 56 (2), 543-555.
Shlisky, J. , Bloom, D. E. , Beaudreault, A. R. , Tucker, K. L. , Keller, H. H. , Freund-Levi, Y. , Fielding, R. A. , Cheng, F. W. & et al. (2017). Nutritional Considerations for Healthy Aging and Reduction in Age-Related Chronic Disease. Advances in Nutrition, 8 (1), 17-26.
Handels, R. L. H. , Vos, S. J. B. , Kramberger, M. G. , Jelic, V. , Blennow, K. , van Buchem, M. , van der Flier, W. , Freund-Levi, Y. & et al. (2017). Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers. Alzheimer's & Dementia, 13 (8), 903-912.
Bos, I. , Vos, S. J. , Frölich, L. , Kornhuber, J. , Wiltfang, J. , Maier, W. , Peters, O. , Rüther, E. & et al. (2017). The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiology of Aging, 56, 33-40.
Wang, X. , Hjorth, E. , Vedin, I. , Eriksdotter, M. , Freund-Levi, Y. , Wahlund, L. , Cederholm, T. , Palmblad, J. & et al. (2015). Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD study. Journal of Lipid Research, 56 (3), 674-681.
Eriksdotter, M. , Vedin, I. , Falahati, F. , Freund-Levi, Y. , Hjorth, E. , Faxen-Irving, G. , Wahlund, L. , Schultzberg, M. & et al. (2015). Plasma Fatty Acid Profiles in Relation to Cognition and Gender in Alzheimer's Disease Patients During Oral Omega-3 Fatty Acid Supplementation: The OmegAD Study. Journal of Alzheimer's Disease, 48 (3), 805-812.
Hall, A. , Mattila, J. , Koikkalainen, J. , Lötjonen, J. , Wolz, R. , Scheltens, P. , Frisoni, G. , Tsolaki, M. & et al. (2015). Predicting progression from cognitive impairment to Alzheimer's disease with the Disease State Index. Current Alzheimer Research, 12 (1), 69-79.
Vos, S. J. B. , Verhey, F. , Frölich, L. , Kornhuber, J. , Wiltfang, J. , Maier, W. , Peters, O. , Rüther, E. & et al. (2015). Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage. Brain, 138 (5), 1327-1338.
Jansen, W. J. , Ossenkoppele, R. , Knol, D. L. , Tijms, B. M. , Scheltens, P. , Verhey, F. R. J. , Visser, P. J. , The Amyloid Biomarker Study Group, . & et al. (2015). Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. Journal of the American Medical Association (JAMA), 313 (19), 1924-1938.
Bloniecki, V. , Aarsland, D. , Cummings, J. , Blennow, K. & Freund-Levi, Y. (2014). Agitation in dementia: relation to core cerebrospinal fluid biomarker levels. Dementia and geriatric cognitive disorders extra, 4 (2), 335-43.
Freund-Levi, Y. , Vedin, I. , Hjorth, E. , Basun, H. , Faxén Irving, G. , Schultzberg, M. , Eriksdotter, M. , Palmblad, J. & et al. (2014). Effects of supplementation with omega-3 fatty acids on oxidative stress and inflammation in patients with Alzheimer's disease: the OmegAD study. Journal of Alzheimer's Disease, 42 (3), 823-831.
Freund-Levi, Y. , Bloniecki, V. , Auestad, B. , Tysen Bäckström, A. C. , Lärksäter, M. & Aarsland, D. (2014). Galantamine versus risperidone for agitation in people with dementia: a randomized, twelve-week, single-center study. Dementia and Geriatric Cognitive Disorders, 38 (3-4), 234-244.
Freund-Levi, Y. , Jedenius, E. , Tysen-Bäckström, A. C. , Lärksäter, M. , Wahlund, L. & Eriksdotter, M. (2014). Galantamine versus risperidone treatment of neuropsychiatric symptoms in patients with probable dementia: an open randomized trial. The American journal of geriatric psychiatry, 22 (4), 341-248.
Holmgren, S. , Hjorth, E. , Schultzberg, M. , Lärksäter, M. , Frenkel, D. , Tysen-Bäckström, A. C. , Aarsland, D. & Freund-Levi, Y. (2014). Neuropsychiatric symptoms in dementia: a role for neuroinflammation?. Brain Research Bulletin, 108, 88-93.
Freund-Levi, Y. , Jedenius, E. , Wahlund, L. , Eriksdotter, M. , Tysen-Bäckström, A. C. & Lärksäter, M. (2014). Response to Bogaiksy's Letter to the Editor. The American journal of geriatric psychiatry, 22 (9), 951-951.
Freund-Levi, Y. , Vedin, I. , Cederholm, T. , Basun, H. , Faxén Irving, G. , Eriksdotter, M. , Hjorth, E. , Schultzberg, M. & et al. (2014). Transfer of omega-3 fatty acids across the blood-brain barrier after dietary supplementation with a docosahexaenoic acid-rich omega-3 fatty acid preparation in patients with Alzheimer's disease: the OmegAD study. Journal of Internal Medicine, 275 (4), 428-436.
Faxén-Irving, G. , Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Basun, H. , Hjorth, E. , Palmblad, J. , Vedin, I. , Cederholm, T. & et al. (2013). Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. Journal of Alzheimer's Disease, 36 (1), 1-6.
Forsberg, A. , Juréus, A. , Cselényi, Z. , Eriksdotter, M. , Freund-Levi, Y. , Jeppsson, F. , Swahn, B. , Sandell, J. & et al. (2013). Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients. European Journal of Nuclear Medicine and Molecular Imaging, 40 (4), 580-593.
Hjorth, E. , Zhu, M. , Toro, V. C. , Vedin, I. , Palmblad, J. , Cederholm, T. , Freund-Levi, Y. , Faxen-Irving, G. & et al. (2013). Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. Journal of Alzheimer's Disease, 35 (4), 697-713.
Bloniecki, V. , Freund-Levi, Y. , Aarsland, D. & Blennow, K. (2012). Agitation - relation to clinical and dementia biomarkers in cerebrospinal fluid. European Journal of Neurology, 19 (s1), 112-112.
Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Garlind, A. , Irving, G. F. , Eriksdotter-Jönhagen, M. , Wahlund, L. & et al. (2012). Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. PLOS ONE, 7 (4).
Hjorth, E. & Freund-Levi, Y. (2012). Immunomodulation of microglia by docosahexaenoic acid and eicosapentaenoic acid.. Current opinion in clinical nutrition and metabolic care, 15 (2), 134-143.
Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Hjorth, E. , Faxén Irving, G. , Eriksdotter-Jönhagen, M. , Schultzberg, M. & et al. (2010). Reduced prostaglandin F-2 alpha release from blood mononuclear leukocytes after oral supplementation of omega 3 fatty acids: the OmegAD study. Journal of Lipid Research, 51 (5), 1179-1185.
Fjellström, C. , Starkenberg, Å. , Wesslén, A. , Tysén Bäckstrom, A. , Faxén-Irving, G. , The OmegAD Study group, . & Freund-Levi, Y. (2010). To Be a Good Food Provider: An Exploratory Study Among Spouses of Persons With Alzheimer's Disease. American Journal of Alzheimer’s Disease and Other Dementia, 25 (6), 521-526.
Nyberg, S. , Eriksdotter Jönhagen, M. , Cselényi, Z. , Halldin, C. , Julin, P. , Olsson, H. , Freund-Levi, Y. , Andersson, J. & et al. (2009). Detection of amyloid in Alzheimer's disease with positron emission tomography using [11C]AZD2184. European Journal of Nuclear Medicine and Molecular Imaging, 36 (11), 1859-1863.
Freund-Levi, Y. , Hjorth, E. , Lindberg, C. , Cederholm, T. , Faxen-Irving, G. , Vedin, I. , Palmblad, J. , Wahlund, L. & et al. (2009). Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study. Dementia and Geriatric Cognitive Disorders, 27 (5), 481-490.
Irving, G. F. , Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Basun, H. , Brismar, K. , Hjorth, E. , Palmblad, J. , Vessby, B. & et al. (2009). Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study. Journal of The American Geriatrics Society, 57 (1), 11-17.
Visser, P. J. , Verhey, F. , Knol, D. L. , Scheltens, P. , Wahlund, L. , Freund-Levi, Y. , Tsolaki, M. , Minthon, L. & et al. (2009). Prevalence and prognostic value of CSF markers of Alzheimer's disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurology, 8 (7), 619-627.
Vedin, I. , Cederholm, T. , Freund-Levi, Y. , Basun, H. , Garlind, A. , Faxén Irving, G. , Jönhagen, M. E. , Vessby, B. & et al. (2008). Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study. American Journal of Clinical Nutrition, 87 (6), 1616-1622.
Freund-Levi, Y. , Basun, H. , Cederholm, T. , Faxén-Irving, G. , Garlind, A. , Grut, M. , Vedin, I. , Palmblad, J. & et al. (2008). Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms. International Journal of Geriatric Psychiatry, 23 (2), 161-169.
Palmblad, J. , Eriksdotter-Jönhagen, M. , Freund-Levi, Y. & Cederholm, T. (2007). [Omega-3-fatty acids protect against dementia. Also early symptoms of mild Alzheimer disease seem to be inhibited]. Läkartidningen, 104 (44), 3268-3271.
Freund-Levi, Y. , Eriksdotter-Jönhagen, M. , Cederholm, T. , Basun, H. , Faxén-Irving, G. , Garlind, A. , Vedin, I. , Vessby, B. & et al. (2006). Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study - A randomized double-blind trial. Archives of Neurology, 63 (10), 1402-1408.
Nordberg, A. , Eriksdotter-Jönhagen, M. , Garlind, A. , Grut, M. , Freund-Levi, Y. , Cornelius, C. , Ekström, A. , Fastbom, J. & et al. (2006). Värt ge symtomlindrande läkemedel vid Alzheimers sjukdom [Administration of symptom-relieving drugs in Alzheimer disease is beneficial]. Läkartidningen, 103 (6), 369-371.
Vedin, I. , Cederholm, T. , Liden, J. , Freund-Levi, Y. , Palmblad, J. & OmegAD, S. G. (2004). Inflammatory gene expression changes by omega-3 fatty acids in patients with Alzheimer's disease. The FASEB Journal, 18 (4), A501-A501.
Freund-Levi, Y. , Jonhagen, M. , Wahlund, L. , Basun, H. , Palmblad, J. & Cederholm, T. (2004). Safety and tolerability of omega-3 fatty acids in patients with Alzheimer's disease. Neurobiology of Aging, 25 (Supplement 2), S471-S471.

Artiklar, forskningsöversikter

Bateman, D. R. , Sascha, G. , Hu, S. , Foster, E. D. , Ruthirakuhan, M. T. , Sellek, A. F. , Mortby, M. E. , Matušková, V. & et al. (2020). Agitation and impulsivity in mid and late life as possible riskmarkers for incident dementia. Alzheimer's & Dementia, 6 (1).