S. aureus-induced sepsis

S. aureus are natural colonizers of the human skin generally without causing disease. However, this Gram-positive bacterium is also one of the most important human pathogens causing fatal infections, such as bacteraemia and sepsis.

• This study investigates the involvement of various inflammasome-mediated processes during the disease cause of sepsis, and relates this information to disease outcome (28-days mortality).
• The inflammasome mechanisms are investigated in patients with S. aureus sepsis; enrolled at the Department of Infectious Diseases at Örebro University Hospital, Sweden.
• The progression is monitored by performing measurements at several time-points during the disease (1, 2, 3, 5 and 7 days after admission).
• Bacterial strains are characterised regarding toxin profile.