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Research projects

S. aureus-induced sepsis

About this project

Project information

Project status

In progress


Bo Söderquist

Research subject

Research environments

S. aureus are natural colonizers of the human skin generally without causing disease. However, this Gram-positive bacterium is also one of the most important human pathogens causing fatal infections, such as bacteraemia and sepsis.

  • This study investigates the involvement of various inflammasome-mediated processes during the disease cause of sepsis, and relates this information to disease outcome (28-days mortality).
  • The inflammasome mechanisms are investigated in patients with S. aureus sepsis; enrolled at the Department of Infectious Diseases at Örebro University Hospital, Sweden.
  • The progression is monitored by performing measurements at several time-points during the disease (1, 2, 3, 5 and 7 days after admission).
  • Bacterial strains are characterised regarding toxin profile.


  • Jan Källman, Örebro Läns Landsting
  • Kristoffer Strålin, KI