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Research Projects

Functional characterization of tyrosine, alanine and tryptophan transport in human fibroblast cells

About this project

About this project

Project information

Projekt Status

In progress

Contact

Nikolaos Venizelos

Research Subject

Research environments

Disturbed dopaminergic, noradrenergic and serotoninergic systems are implicated as causes of schizophrenia and bipolar disorder. Our working hypothesis in this project is that one reason behind this disturbed neurotransmission can be a change in the transport of the precursor amino acids, tyrosine and tryptophan, which secondarily could lead to disturbances in the dopaminergic.-noradrenergic and serotoninergic neurotransmitter system. We to perform a systematic functional characterization of tyrosine, tryptophan and alanine transport in fibroblasts from healthy controls, with respect to the system-, L and A and to their isoforms (LAT1, LAT2, LAT3, LAT4) (ATA1, ATA2).

Researchers

Research Teams

Research funding bodies

  • The Magnus Bergvall Foundation
  • Swedish Research Council

Collaborators

  • Tommy Lewander, Uppsala universitet