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Robert Kruse

Befattning: Universitetslektor, adjungerad Organisation: Institutionen för medicinska vetenskaper

Telefon: Telefonnummer saknas

Rum: X3111

Forskningsämne

Biomedicin

Om Robert Kruse

Jag är i grunden utbildad till molekylärbiolog vid Lunds universitet och både min tidigare och pågående vetenskapliga verksamhet grundar sig i en önskan av att förstå komplexa förhållanden vid sjukdomar, ex kroppens systemiska svar vid infektion. En del av min forskning har fokus på värdsvar vid urinvägsinfektion med bakterien Escherichia coli där jag fokuserar på globala analyser av transkriptomets förändringar i både human vävnad och i uropatogena bakterier vid infektion samt resistensutveckling vid behandling av antibiotika.

Min grundanställning på Kliniskt Forsknings Centrum möjliggör forskningssamarbeten med många olika forskningsgrupper, där min roll varierar mellan projektledning, handledning samt metodologiska och bioinformatiska analyser och konsultation. Projekten innefattar omics-relaterad forskning, till exempel transkriptomet, proteomet och metabolomet, vid olika sjukdomar, till exempel inflammatorisk tarmsjukdom, diabetes, bröstcancer, låg födselvikt, samt muskulära förändringar vid muskelkontraktion.

Jag ingår i forskningsmiljön Inflammatory Response and Infection Susceptibility Centre (iRiSC) där jag bland annat leder ett tema runt metabolismens koppling till immunologiskt svar, så kallat immunometabolism, vid inflammation. Utöver detta är jag del i ett nationellt forskningsprojekt kring inflammatorisk tarmsjukdom, BIO IBD, där jag är vetenskaplig koordinator. Projektet har fokus på upptäckt av biomarkörer för diagnos, prognos och terapisvar där olika delar av projektet berör min egen forskning kring mikroRNAs (miRNAs) regulatoriska roll samt deras samspel med mikrobiota och de förändringar i mikrobiotan som ses vid inflammatorisk tarmsjukdomen.

Pågående projekt

Avslutade projekt

Forskargrupper

Publikationer

Artiklar i tidskrifter | Konferensbidrag | Manuskript |

Artiklar i tidskrifter

Lundström, M. L. , Peterson, C. , Lampinen, M. , Hedin, C. R. H. , Keita, Å. V. , Kruse, R. , Magnusson, M. K. , Lindqvist, C. M. & et al. (2023). Fecal Biomarkers of Neutrophil and Eosinophil Origin Reflect the Response to Biological Therapy and Corticosteroids in Patients With Inflammatory Bowel Disease. Clinical and Translational Gastroenterology, 14 (8).
Scherbak, N. N. , Kruse, R. , Nyström, T. & Jendle, J. (2023). Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial. Diabetes & metabolism journal, 47 (5), 668-681.
Scherbak, N. , Kruse, R. , Nyström, T. & Jendle, J. (2023). Glimepiride Compared to Liraglutide Increases Plasma Levels of miR-206, miR-182-5p, and miR-766-3p in Type 2 Diabetes Mellitus: A Randomized Controlled Trial (Diabetes Metab J 2023;47:668-81). Diabetes & metabolism journal, 47 (6), 882-883.
Nikaein, N. , Tuerxun, K. , Cedersund, G. , Eklund, D. , Kruse, R. , Särndahl, E. , Nånberg, E. , Thonig, A. & et al. (2023). Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation. Journal of Biological Chemistry, 299 (10).
Tuerxun, K. , Eklund, D. , Wallgren, U. , Dannenberg, K. , Repsilber, D. , Kruse, R. , Särndahl, E. & Kurland, L. (2023). Predicting sepsis using a combination of clinical information and molecular immune markers sampled in the ambulance. Scientific Reports, 13 (1).
Chelslín, F. , Lodefalk, M. & Kruse, R. (2023). Smoking during pregnancy is associated with the placental proteome. Reproductive Toxicology, 119.
Tuerxun, K. , Midtbö, K. , Särndahl, E. , Vorontsov, E. , Karlsson, R. , Persson, A. , Kruse, R. & Eklund, D. (2022). Cytokine responses to LPS in reprogrammed monocytes are associated with the transcription factor PU.1. Journal of Leukocyte Biology, 112 (4), 679-692.
Juzenas, S. , Hübenthal, M. , Lindqvist, C. M. , Kruse, R. , Steiert, T. A. , Degenhardt, F. , Schulte, D. , Nikolaus, S. & et al. (2022). Detailed transcriptional landscape of peripheral blood points to increased neutrophil activation in treatment-naïve inflammatory bowel disease. Journal of Crohn's & Colitis, 16 (7), 1097-1109.
Moraes Holst, L. , Halfvarson, J. , Carlson, M. , Hedin, C. , Kruse, R. , Lindqvist, C. M. , Bergemalm, D. , Almér, S. & et al. (2022). Downregulated Mucosal Autophagy, Alpha Kinase-1 and IL-17 Signaling Pathways in Active and Quiescent Ulcerative Colitis. Clinical and Experimental Gastroenterology, 15, 129-144.
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in human term placenta. Frontiers in Medicine, 9.
Persson, K. , Petersson, U. , Johansson, C. , Demirel, I. & Kruse, R. (2022). Transcriptional alterations in bladder epithelial cells in response to infection with different morphological states of uropathogenic Escherichia coli. Scientific Reports, 12 (1).
Chelslín, F. , Kruse, R. , Östling, H. & Lodefalk, M. (2021). Differential microRNA expression in placentas of small-for-gestational age neonates with and without exposure to poor maternal gestational weight gain. Journal of Perinatal Medicine, 49 (5), 632-635.
Berg von Linde, M. , Johansson, K. , Kruse, R. , Helenius, G. , Samano, N. , Friberg, Ö. , Frøbert, A. M. & Fröbert, O. (2021). Expression of Paracrine Effectors in Human Adipose-Derived Mesenchymal Stem Cells Treated With Plasma From Brown Bears (Ursus arctos). Clinical and Translational Science, 14 (1), 317-325.
Demirel, I. , Persson, A. , Brauner, A. , Särndahl, E. , Kruse, R. & Persson, K. (2020). Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils. Scientific Reports, 10 (1).
Serhan, C. N. , Gupta, S. K. , Perretti, M. , Godson, C. , Brennan, E. , Li, Y. , Soehnlein, O. , Shimizu, T. & et al. (2020). The Atlas of Inflammation Resolution (AIR). Molecular Aspects of Medicine, 74.
Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2019). Placental expression of microRNAs in infants born small for gestational age. Placenta, 81, 46-53.
Demirel, I. , Persson, A. , Brauner, A. , Särndahl, E. , Kruse, R. & Persson, K. (2018). Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells. Frontiers in Cellular and Infection Microbiology, 8.
Bergemalm, D. , Kruse, R. , Sapnara, M. , Halfvarson, J. & Hultgren Hörnquist, E. (2017). Elevated fecal peptidase D at onset of colitis in Galphai2(-/-) mice, a mouse model of IBD. PLOS ONE, 12 (3).
Bang, C. S. , Demirel, I. , Kruse, R. & Persson, K. (2017). Global gene expression profiling and antibiotic susceptibility after repeated exposure to the carbon monoxide-releasing molecule-2 (CORM-2) in multidrug-resistant ESBL-producing uropathogenic Escherichia coli. PLOS ONE, 12 (6).
Andersson, E. , Bergemalm, D. , Kruse, R. , Neumann, G. , D'Amato, M. , Repsilber, D. & Halfvarson, J. (2017). Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles. PLOS ONE, 12 (10).
Demirel, I. , Rangel, I. , Petersson, U. , Persson, K. & Kruse, R. (2017). Transcriptional Alterations of Virulence-Associated Genes in Extended Spectrum Beta-Lactamase (ESBL)-Producing Uropathogenic Escherichia coli during Morphologic Transitions Induced by Ineffective Antibiotics. Frontiers in Microbiology, 8.
Vumma, R. , Bang, C. S. , Kruse, R. , Johansson, K. & Persson, K. (2016). Antibacterial effects of nitric oxide on uropathogenic Escherichia coli during bladder epithelial cell colonization-a comparison with nitrofurantoin. Journal of antibiotics (Tokyo. 1968), 69 (3), 183-186.
Sahlberg Bang, C. , Kruse, R. , Johansson, K. & Persson, K. (2016). Carbon monoxide releasing molecule-2 (CORM-2) inhibits growth of multidrug-resistant uropathogenic Escherichia coli in biofilm and following host cell colonization. BMC Microbiology, 16 (1).
Demirel, I. , Kruse, R. , Önnberg, A. & Persson, K. (2015). Ceftibuten-induced filamentation of extended spectrum beta lactamase (ESBL)-producing uropathogenic Escherichia coli alters host cell responses during an in vitro infection. Microbial Pathogenesis, 78, 52-62.
Kruse, R. , Demirel, I. , Säve, S. & Persson, K. (2014). IL-8 and global gene expression analysis define a key role of ATP in renal epithelial cell responses induced by uropathogenic bacteria. Purinergic Signalling Purinergic Signalling, 10 (3), 499-508.
Bang, C. S. , Kruse, R. , Demirel, I. , Önnberg, A. , Söderquist, B. & Persson, K. (2014). Multiresistant uropathogenic extended-spectrum β-lactamase (ESBL)-producing Escherichia coli are susceptible to the carbon monoxide releasing molecule-2 (CORM-2).. Microbial Pathogenesis, 66, 29-35.
Demirel, I. , Säve, S. , Kruse, R. & Persson, K. (2013). Expression of suppressor of cytokine signalling 3 (SOCS3) in human bladder epithelial cells infected with uropathogenic Escherichia coli. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 121 (2), 158-167.
Zhang, B. , Elmabsout, A. A. , Khalaf, H. , Basic, V. T. , Jayaprakash, K. , Kruse, R. , Bengtsson, T. & Sirsjö, A. (2013). The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation. BMC Genomics, 14, 770.
Kruse, R. , Säve, S. & Persson, K. (2012). Adenosine triphosphate induced P2Y(2) receptor activation induces proinflammatory cytokine release in uroepithelial cells. Journal of Urology, 188 (6), 2419-2425.
Jensen-Waern, M. , Kruse, R. & Lundgren, T. (2012). Oral immunosuppressive medication for growing pigs in transplantation studies. Laboratory Animals, 46 (2), 148-151.
Kruse, R. , Dutta, P. C. & Morrell, J. M. (2011). Colloid centrifugation removes seminal plasma and cholesterol from boar spermatozoa. Reproduction, Fertility and Development, 23 (7), 858-65.
Kruse, R. , Essén-Gustavsson, B. , Fossum, C. & Jensen-Waern, M. (2008). Blood concentrations of the cytokines IL-1beta, IL-6, IL-10, TNF-alpha and IFN-gamma during experimentally induced swine dysentery. Acta Veterinaria Scandinavica, 50.

Konferensbidrag

Grännö, O. , Salomon, B. , Lindqvist, C. M. , Hedin, C. R. H. , Carlson, M. , Dannenberg, K. , Andersson, E. , Söderholm, J. D. & et al. (2024). Preclinical protein signatures in blood predict Crohn's disease and Ulcerative colitis several years before the diagnosis. I: Journal of Crohn's & Colitis. Konferensbidrag vid 9th Congress of ECCO, Stockholm, Sweden, February 21-24, 2024. (ss. I660-I661). Oxford University Press.
Salomon, B. , Carlson, M. , Bergemalm, D. , Hedin, C. R. H. , Söderholm, J. D. , Keita, Å. V. , Carsten, A. , Grip, O. & et al. (2024). Prognostic potential of mucosal proteins in Ulcerative Colitis. I: Journal of Crohn's & Colitis. Konferensbidrag vid 16th Congress of ECCO - European Crohn’s and Colitis Organisation (ECCO'21), (Virtual congress), July 2-3, 8-10, 2021. (ss. I544-I545). Oxford University Press.
Mathisen, C. B. , Nyström, N. , Bazov, I. , Andersen, S. , Olbjørn, C. , Perminow, G. , Kristensen, V. A. , Opheim, R. & et al. (2023). A novel diagnostic serum protein signature for paediatric Inflammatory Bowel Disease: A discovery and validation study in two independent inception cohorts. I: Journal of Crohn's & Colitis. Konferensbidrag vid 8th Congress of ECCO Copenhagen, Denmark, March 1-4, 2023. (ss. I71-I73). Oxford University Press.
Bazov, I. , Kruse, R. , Bergemalm, D. , Eriksson, C. , Hedin, C. R. , Carlson, M. , van Nieuwenhoven, M. , Keita, Å. V. & et al. (2023). A novel serum protein signature as biomarker for Inflammatory Bowel Disease: A diagnostic performance and prediction modelling study using data from two independent inception cohorts. I: Journal of Crohn's & Colitis. Konferensbidrag vid 18th Congress of ECCO Copenhagen, Denmark, March 1-4, 2023. (ss. I314-I315). Oxford University Press.
Salihovic, S. , Nyström, N. , Mathisen, C. B. , Andersen, S. , Olbjørn, C. , Perminow, G. , Opheim, R. , Detlie, T. E. & et al. (2023). Identification and validation of a lipidomic signature as a novel diagnostic biomarker of paediatric Inflammatory Bowel Disease. I: Journal of Crohn's & Colitis. Oxford University Press.
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in human term placenta may improve our understanding of fetal growth. I: Hormone Research in Paediatrics. Konferensbidrag vid 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (ss. 247-247). S. Karger.
Östling, H. , Lodefalk, M. , Backman, H. & Kruse, R. (2022). Global microRNA and protein expression in humanterm placenta may improve our understandingof fetal growth. I: Hormone Research in Paediatrics. Konferensbidrag vid 60th Annual Meeting of the European Society for Paediatric Endocrinology (ESPE), Rome, Italy, September 15–17, 2022. (ss. 247-247). S. Karger.
Welander, E. , Åström, M. , Enonge Fotabe, L. , Kardeby, C. , Tina, E. , Elgbratt, K. , Pourlotfi, A. , Abawi, A. & et al. (2018). Integrated analysis indicates reciprocal immune response dysregulations between bone marrow multipotent stromal cells and granulocytes at the mRNA but not at the protein level in myelofibrosis. Konferensbidrag vid Fortbildningsdagar i hematologi, Umeå, 3-5 Oktober, 2018.
Östling, H. , Kruse, R. , Helenius, G. & Lodefalk, M. (2017). Infants born small-for-gestational age have different placental expression of microRNAs. I: Hormone Research in Paediatrics. Konferensbidrag vid 10th International Meeting of Pediatric Endocrinology, Washington D.C., USA, September 14-17, 2017. (ss. 100-101). S. Karger.
Andersson, E. , Bergemalm, D. , Kruse, R. , D'Amato, M. , Repsilber, D. & Halfvarson, J. (2016). Inflammatory biomarkers in serum discriminate Crohn's disease and ulcerative colitis from healthy controls. I: Journal of Crohn's & Colitis. Oxford University Press.

Manuskript

Demirel, I. , Kruse, R. , Önnberg, A. & Persson, K. Antibiotic-induced filamentation of extended spectrum beta lactamase (ESBL)-producing uropathogenic E. coli alters host cell responses during an in vitro infection.
Göthlin Eremo, A. , Tina, E. , Kruse, R. , Fransén, K. , Wegman, P. , Repsilber, D. , Montgomery, S. , Sollie, T. & et al. Gene expression profiles in breast tumors from tamoxifen treated patients with and without distant recurrence.
Sahlberg Bang, C. , Kruse, R. & Persson, K. Global gene expression profiling and antibiotic susceptibility after repeated exposure to the carbon monoxide-releasing molecule-2 (CORM-2) in multidrug-resistant ESBL-producing uropathogenic Escherichia coli.
Carstens, A. , Björkqvist, O. , Lindqvist, C. M. , Rangel, I. , Repsilber, D. , Eriksson, C. , Bergemalm, D. , Bresso, F. & et al. Gut microbiota associated with treatment outcome to biological treatment in inflammatory bowel disease.
Folkesson, M. , Kruse, R. & Kadi, F. HSP27 is not mandatory for the hypertrophy of human skeletal muscle cells.