Systems medicine
About this team
Team information
Our main research area is systems medicine, particularly metabolomics applications in biomedical research and related integrative bioinformatics. Specifically, we am particularly interested in the identification of disease vulnerabilities associated with different metabolic phenotypes and the underlying mechanisms linking these vulnerabilities with the development of specific disorders or their co-morbidities. Such in depth understanding of the metabolic phenotypes in health and disease is crucial if one is to implement personalized medicine. The primary research areas have been non-alcoholic fatty liver disease, metabolic co-morbidities in psychotic disorders and investigations of early metabolic disturbances preceding immune mediated inflammatory disorders, specifically type 1 diabetes and celiac disease.
Dr. Orešič also initiated the popular MZmine open source project, leading to popular software for metabolomics data processing. We are interested in continuing to contribute to this project with novel methods.
Research projects
- Blood-based metabolomics to predict severity and patient outcomes in traumatic brain injury (meTBI)
- EPoS - Elucidating Pathways of Steatohepatitis
- Health Consequences of Environmental Exposures in Early Life
- Human exposure to per- and polyfluoroalkyl substances? Role of the gut microbiome and bile acid metabolism in mediating impact (PFASgut)
- Lipid pathways en route to islet autoimmunity and type 1 diabetes
- LipidNET- Pan-European Network in Lipidomics and Epilipidomics?
- LITMUS
- Metabolomic and Proteomic markers staging progression to type 1 diabetes in autoantibody positive children
