Maria Larsson
Title: Researcher School/office: School of Science and Technology
Email:
Phone: +46 19 301370
Room: B3313
About Maria Larsson
My research area is environmental chemistry focusing on identification, exposure and receptor-mediated mixture effects (cocktail effects) of organic pollutants in complex mixtures. I am using an effect-directed analysis (EDA) approach, combining GC/MS and LC/MS analysis, and mechanism-specific bioreporter assays and high-resolution fractionation techniques for chemical and toxicological characterization and identification of key toxicants in complex mixtures, like soil, air and dust. Special focus is on polycyclic aromatic compounds.
I am the lab director of the bioanalytical laboratory in the Environment and Health group at MTM Research Centre.
Research projects
- APPLICERA: Applicable site-specific environmental risk assessment of contaminated soils
- Bioanalytical screening of POPs in otters
- Bioanalytical studies of soils and sediments
- Biokol - Från organiskt avfall till resurs för nyttiggörande av jordavfall
- Chemical and toxicological characterisation of PAHs and related compounds in road dust
- Effect-based strategy for identification and assessment of potential health effects of hazardous organic chemicals in indoor environments
- EPHEMARE - Ecotoxicological effects of microplastics in marine ecosystems
- Fish & Cocktails
- Identifiera: Identification of toxicity driving polycyclic aromatic compounds (PAC s) for improving environmental risk assessment of contaminated sites
- Mixture-Risk
- Nanosafety Project
- PAC-Risk
- PFAS-Risk
- Environmental and health effects of fire fighting foams
- SOILEFFECT: Development of bioreporter-based survey and health risk assessment of toxic chemicals in contaminated areas
- SOILTOX: processoptimering och innovation av marksaneringsmetoder med hjälp av bioanalytiska toxicitetstester
Research teams
Publications
Articles in journals |
Articles, reviews/surveys |
Doctoral theses, comprehensive summaries |
Manuscripts |
Reports |
Articles in journals
Titaley, I. , Lam, M. M. , Bülow, R. , Enell, A. , Wiberg, K.
& Larsson, M. (2021). Characterization of polycyclic aromatic compounds in historically contaminated soil by targeted and non-targeted chemical analysis combined with in vitro bioassay. Environmental Pollution, 289.
Cormier, B. , Le Bihanic, F. , Cabar, M. , Crebassa, J. , Blanc, M. , Larsson, M. , Dubocq, F. , Yeung, L. W. Y.
& et al.
(2021). Chronic feeding exposure to virgin and spiked microplastics disrupts essential biological functions in teleost fish. Journal of Hazardous Materials, 415.
Volchko, Y. , Berggren Kleja, D. , Back, P. , Tiberg, C. , Enell, A. , Larsson, M. , Jones, C. M. , Taylor, A.
& et al.
(2020). Assessing costs and benefits of improved soil quality management in remediation projects: A study of an urban site contaminated with PAH and metals. Science of the Total Environment, 707.
Titaley, I. A. , Eriksson, U.
& Larsson, M. (2020). Rapid extraction method of polycyclic aromatic compounds in soil using basic silica selective pressurized liquid extraction. Journal of Chromatography A, 1618.
Titaley, I. , Massey Simonich, S. L.
& Larsson, M. (2020). Recent Advances in the Study of the Remediation of Polycyclic Aromatic Compound (PAC)-Contaminated Soils: Transformation Products, Toxicity, and Bioavailability Analyses. Environmental Science and Technology Letters, 7 (12), 873-882.
Schönlau, C. , Larsson, M. , Lam, M. M. , Engwall, M. , Giesy, J. P. , Rochman, C.
& Kärrman, A. (2019). Aryl hydrocarbon receptor-mediated potencies in field-deployed plastics vary by type of polymer. Environmental Science and Pollution Research, 26 (9), 9097-9088.
Meyer-Alert, H. , Larsson, M. , Hollert, H.
& Keiter, S. (2019). Benzo[a]pyrene and 2,3-benzofuran induce divergent temporal patterns of AhR-regulated responses in zebrafish embryos (Danio rerio). Ecotoxicology and Environmental Safety, 183.
Schönlau, C. , Larsson, M. , Dubocq, F. , Rotander, A. , Van der Zande, R. , Engwall, M.
& Kärrman, A. (2019). Effect-Directed Analysis of Ah Receptor-Mediated Potencies in Microplastics Deployed in a Remote Tropical Marine Environment. Frontiers in Environmental Science, 7.
Meyer-Alert, H. , Ladermann, K. , Larsson, M. , Schiwy, S. , Hollert, H.
& Keiter, S. H. (2018). A temporal high-resolution investigation of the Ah-receptor pathway during early development of zebrafish (Danio rerio). Aquatic Toxicology, 204, 117-129.
Lam, M. M. , Bülow, R. , Engwall, M. , Giesy, J. P.
& Larsson, M. (2018). Methylated PACs Are More Potent than Their Parent Compounds: A Study on AhR-mediated Activity, Degradability and Mixture Interactions in the H4IIE-luc Assay. Environmental Toxicology and Chemistry, 37 (5), 1409-1419.
Lam, M. M. , Engwall, M. , Denison, M. S.
& Larsson, M. (2018). Methylated polycyclic aromatic hydrocarbons and/or their metabolites are important contributors to the overall estrogenic activity of polycyclic aromatic hydrocarbon-contaminated soils. Environmental Toxicology and Chemistry, 37 (2), 385-397.
Larsson, M. , Lam, M. M. , van Hees, P. , Giesy, J. P.
& Engwall, M. (2018). Occurrence and leachability of polycyclic aromatic compounds in contaminated soils: Chemical and bioanalytical characterization. Science of the Total Environment, 622-623, 1476-1484.
Hafner, C. , Gartiser, S. , Garcia-Kaeufer, M. , Schiwy, S. , Hercher, C. , Meyer, W. , Achten, C. , Larsson, M.
& et al.
(2015). Investigations on sediment toxicity of German rivers applying a standardized bioassay battery. Environmental Science and Pollution Research, 22 (21), 16358-16370.
Larsson, M. , Giesy, J. P.
& Engwall, M. (2014). AhR-mediated activities of polycyclic aromatic compound (PAC) mixtures are predictable by the concept of concentration addition. Environment International, 73, 94-103.
Westman, O. , Larsson, M. , Venizelos, N. , Hollert, H.
& Engwall, M. (2014). An oxygenated metabolite of benzo[a]pyrene increases hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 21 (9), 6243-6251.
Larsson, M. , Hagberg, J. , Giesy, J. P.
& Engwall, M. (2014). Time-dependent relative potency factors for polycyclic aromatic hydrocarbons and their derivatives in the H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 33 (4), 943-953.
Larsson, M. , Hagberg, J. , Rotander, A. , van Bavel, B.
& Engwall, M. (2013). Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils. Environmental Science and Pollution Research, 20 (12), 8511-8520.
Buitrago, B. H. , Munoz, P. F. , Ribe, V. , Larsson, M. , Engwall, M. , Wojciechowska, E.
& Waara, S. (2013). Hazard assessment of sediments from a wetland system for treatment of landfill leachate using bioassays. Ecotoxicology and Environmental Safety, 97, 255-262.
Engwall, M. , Venizelos, N. , Westman, O. , Larsson, M. , Nordén, M. , Hollert, H.
& Johansson, J. (2013). Polycyclic aromatic hydrocarbons (PAHs) reduce hepatic beta-oxidation of fatty acids in chick embryos. Environmental Science and Pollution Research, 20 (3), 1881-1888.
Larsson, M. , Orbe, D.
& Engwall, M. (2012). Ah receptor activating capacity of polycyclic aromatic hydrocarbon derivatives. Toxicology Letters, 211 (Supplement), s127.
Larsson, M. , Orbe, D.
& Engwall, M. (2012). Exposure time-dependent effects on the relative potencies and additivity of PAHs in the Ah receptor-based H4IIE-luc bioassay. Environmental Toxicology and Chemistry, 31 (5), 1149-1157.
Westman, O. , Nordén, M. , Larsson, M. , Venizelos, N. , Hollert, H.
& Engwall, M. (2012). Reduced beta-oxidation in avian following exposure of polycyclic aromatic hydrocarbons. Toxicology Letters, 211 (Supplement), s86-s87.
Articles, reviews/surveys
Lundstedt, S. , Bandowe, B. A. M. , Wilcke, W. , Boll, E. , Christensen, J. H. , Vila, J. , Grifoll, M. , Faure, P.
& et al.
(2014). First intercomparison study on the analysis of oxygenated polycyclic aromatic hydrocarbons (oxy-PAHs) and nitrogen heterocyclic polycyclic aromatic compounds (N-PACs) in contaminated soil. TrAC. Trends in analytical chemistry, 57, 83-92.
Doctoral theses, comprehensive summaries
Larsson, M. (2013). Chemical and bioanalytical characterisation of PAH-contaminated soils: identification, availability and mixture toxicity of AhR agonists.
(Doctoral dissertation).
(Comprehensive summary)
Örebro: Örebro universitet.
Manuscripts
Westman, O. , Larsson, M. , Venizelos, N. , Hollert, H.
& Engwall, M. An oxygenated metabolite of benzo[a]pyrene increases hepatic β-oxidation of fatty acids in chick embryos.
Larsson, M. , Hagberg, J. , Rotander, A. , van Bavel, B.
& Engwall, M. Chemical and bioanalytical characterisation of PAHs in risk assessment of remediated PAH-contaminated soils.
Westman, O. , Larsson, M. , Hollert, H.
& Engwall, M. Comparative study and characterization of mutagenicity and AhR-agonistic potency of contaminated soil, remediated soil, urban city soil and rural soil.
Larsson, M. , Giesy, J. P.
& Engwall, M. Concentration-addition in risk assessment : prediction of potential AhR-mediated activity in multiple polycyclic aromatic compound (PAC) mixtures.
Lam, M. M. , Bülow, R. , Engwall, M. , Giesy, J. P.
& Larsson, M. Methylated PACs are more potent than their parent compounds : a study on AhR-mediated activity, degradability and mixture interactions in the H4IIE-luc assay.
Lam, M. M. , Engwall, M. , Denison, M. S. , Giesy, J. P.
& Larsson, M. Polyoxymethylene (POM) is a suitable tool for effect-based hazard assessment of PAC-contaminated soil.
Schönlau, C. , Holmes, B. , Larsson, M. , Engwall, M.
& Kärrman, A. Screening for bioactivities in three types of microplastics deployed in Swedish aquatic environments using a battery of reporter gene assays.
Larsson, M. , Hagberg, J. , Giesy, J. P.
& Engwall, M. Time-dependent relative potency factors (REPS) for polycyclic aromatic hydrocarbons and their derivatives in the h4iie-luc.
Reports
Kärrman, A. , Bjurlid, F. , Hagberg, J. , Ricklund, N. , Larsson, M. , Stubleski, J.
& Hollert, H. (2016). Study of environmental and human health impacts of firefighting agents: A technical report. Örebro, Sweden: Örebro University.
Engwall, M.
& Larsson, M. (2009). Bioanalys av organiska föroreningars biotillgänglighet: tillämpning i sanerade massor. Stockholm: Naturvårdsverket (Rapport 5931).