This page in English

Hong Zhang

Befattning: Biträdande professor Organisation: Institutionen för medicinska vetenskaper

Rum: X1101

Om Hong Zhang

With MD and PhD, I became a “docent” in experimental oncology and in biomedicine. As an associate (biträdande) professor, I am now working at School of Medical Sciences, Örebro University.
Research and future plan
I have been working with medical research since 1985, and have set up broad international and national collaborations, working with a variety of research projects. As a major and co-supervisor, I have been guiding several post-doctors, PhD students, master students and other research students. As main and co-applicant, I have received various international and national research grants. Together with my co-workers, I have published >100 scientific publications in various international journals including Lancet, JCO, JNCI, etc., reviews and chapter of book.
Colorectal cancer is a common malignancy and one of the most predominant causes of death in cancer. Although long-standing efforts on early diagnosis and efficient treatment have improved patient survival, the successes have not been fully confirmed, and the benefits from radiotherapy and chemotherapy are still under investigation. Molecular biology study to identify genetic alterations of colorectal cancer should lead to improvements in early diagnosis and may provide precise method to select patients benefiting from radiotherapy and chemotherapy.

Teaching and future plan
I have been deeply engaged in university teaching from ground to advanced courses in pathology, tumour biology, endocrinology, pharmacology and toxicology. I have been involved in problem based learning (PBL) in medicine and biomedicine. My strong desire is to improve the quality and quantity in our medical program: such as to create video golden lectures from the best lectures; to contribute more high quality lectures in cancer biology and pathology; to create more efficient model of PBL including to introduce my modified PBL methods to the PBL teaching; and to qualify a tutorship in PBL etc.

Publikationer

Publikationer

Artiklar i tidskrifter | Artiklar, forskningsöversikter | Konferensbidrag | Manuskript |

Artiklar i tidskrifter

Zhang, X. , Li, M. , Ye, S. , Shen, K. , Yuan, H. , Bakhtyar, S. , Peng, Q. , Liu, Y. & et al. (2024). CBD2: A functional biomarker database for colorectal cancer. iMeta, 3 (1).
Fan, C. , Fang, C. , Wang, W. , Lv, Z. , Zhang, X. , Long, F. , Jiang, Z. , Li, Y. & et al. (2024). Mismatch repair protein deficiency and its implications on distant metastasis in colorectal cancer: A comprehensive analysis. Cancer Medicine, 13 (7).
Pathak, S. , Meng, W. , Sriramulu, S. , Jothimani, G. , Jangamreddy, J. R. , Banerjee, A. , Ganesan, A. T. , Adell, G. & et al. (2023). Association of MicroRNA-652 Expression with Radiation Response of Colorectal Cancer: A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy. Current Gene Therapy, 23 (5), 356-367.
Cui, W. , Xie, N. , Lam, E. W. , Hahn-Stromberg, V. , Liu, N. , Zhang, H. & Sun, X. (2023). High expression of cytoplasmic FOXO3 protein associated with poor prognosis of rectal cancer patients: A study from Swedish clinical trial of preoperative radiotherapy to big database analysis. Heliyon, 9 (5).
Ma, S. , Zhao, Y. , Liu, X. , Zhang, A. S. , Zhang, H. , Hu, G. & Sun, X. (2022). CD163 as a Potential Biomarker in Colorectal Cancer for Tumor Microenvironment and Cancer Prognosis: A Swedish Study from Tissue Microarrays to Big Data Analyses. Cancers, 14 (24).
Zhang, X. , Zhang, H. , Fan, C. , Hildesjö, C. , Shen, B. & Sun, X. (2022). Loss of CHGA Protein as a Potential Biomarker for Colon Cancer Diagnosis: A Study on Biomarker Discovery by Machine Learning and Confirmation by Immunohistochemistry in Colorectal Cancer Tissue Microarrays. Cancers, 14 (11).
Ganesan, H. , Nandy, S. K. , Banerjee, A. , Pathak, S. , Zhang, H. & Sun, X. (2022). RNA-Interference-Mediated miR-122-Based Gene Regulation in Colon Cancer, a Structural In Silico Analysis. International Journal of Molecular Sciences, 23 (23).
Fan, C. , Lu, R. , Fang, C. , Zhang, X. , Lv, Z. , Li, Y. , Zhang, H. , Zhou, Z. & et al. (2021). Expression profile, molecular functions, and prognostic significance of miRNAs in primary colorectal cancer stem cells. Aging, 13 (8), 12067-12085.
Pham, T. D. , Fan, C. , Zhang, H. & Sun, X. (2020). Artificial intelligence-based 5-year survival prediction and prognosis of DNp73 expression in rectal cancer patients. Clinical and translational medicine, 10 (4).
Liu, X. , Xueli, Z. , Chen, J. , Ye, B. , Ren, S. , Lin, Y. , Sun, X. , Zhang, H. & et al. (2020). CRC-EBD: Epigenetic Biomarker Database for Colorectal Cancer. Frontiers in Genetics, 11.
Meng, W. , Pathak, S. , Xueli, Z. , Adell, G. , Jarlsfelt, I. , Holmlund, B. , Wang, Z. , Zhang, A. S. & et al. (2020). Expressions of miR-302a, miR-105, and miR-888 Play Critical Roles in Pathogenesis, Radiotherapy, and Prognosis on Rectal Cancer Patients: A Study From Rectal Cancer Patients in a Swedish Rectal Cancer Trial of Preoperative Radiotherapy to Big Database Analyses. Frontiers in Oncology, 10.
Pham, T. D. , Fan, C. , Pfeifer, D. , Zhang, H. & Sun, X. (2020). Image-Based Network Analysis of DNp73 Expression by Immunohistochemistry in Rectal Cancer Patients. Frontiers in Physiology, 10.
Zhang, X. , Zhang, H. , Shen, B. & Sun, X. (2020). Novel MicroRNA Biomarkers for Colorectal Cancer Early Diagnosis and 5-Fluorouracil Chemotherapy Resistance but Not Prognosis: A Study from Databases to AI-Assisted Verifications. Cancers, 12 (2).
Fan, C. , Kopsida, M. , Liu, Y. , Zhang, H. , Gao, J. , Arbman, G. , Cao, S. , Li, Y. & et al. (2020). Prognostic Heterogeneity of MRE11 Based on the Location of Primary Colorectal Cancer Is Caused by Activation of Different Immune Signals. Frontiers in Oncology, 9.
Han, S. , Jiang, X. , Sun, X. , Zhang, H. , Li, C. , Zhao, Z. & Yu, W. (2019). Application value of CyTOF 2 mass cytometer technology at single-cell level in human gastric cancer cells. Experimental Cell Research, 384 (1).
Zhang, X. , Zhang, H. , Shen, B. & Sun, X. (2019). Chromogranin-A Expression as a Novel Biomarker for Early Diagnosis of Colon Cancer Patients. International Journal of Molecular Sciences, 20 (12).
Zhang, X. , Sun, X. , Shen, B. & Zhang, H. (2019). Potential Applications of DNA, RNA and Protein Biomarkers in Diagnosis, Therapy and Prognosis for Colorectal Cancer: A Study from Databases to AI-Assisted Verification. Cancers, 11 (2).
Wang, C. , Chao, C. , Liu, H. , Zhu, Y. , Adell, G. , Jarlsfelt, I. , Zhang, H. & Sun, X. (2019). Prognostic value of nuclear FBI-1 in patients with rectal cancer with or without preoperative radiotherapy. Oncology Letters, 18 (5), 5301-5309.
Evert, J. , Pathak, S. , Sun, X. & Zhang, H. (2018). A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer. Journal of Cancer, 9 (11), 2046-2053.
Zhang, X. , Sun, X. , Cao, Y. , Ye, B. , Peng, Q. , Liu, X. , Shen, B. & Zhang, H. (2018). CBD: a biomarker database for colorectal cancer. Database: The Journal of Biological Databases and Curation.
Wang, C. , Zhou, J. , Cheng, Q. , Zhou, Y. , Zhang, H. & Sun, X. (2018). FBI-1 mRNA in normal mucosa is an independent prognostic factor in colorectal cancer patients. International Journal of Clinical and Experimental Pathology, 11 (2), 642-649.
Xiao, C. , Wang, Y. , Zheng, M. , Chen, J. , Song, G. , Zhou, Z. , Zhou, C. , Sun, X. & et al. (2018). RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer. Cancer Science, 109 (4), 1075-1087.
Song, G. , Xu, S. , Zhang, H. , Wang, Y. , Xiao, C. , Jiang, T. , Wu, L. , Zhang, T. & et al. (2016). TIMP1 is a prognostic marker for the progression and metastasis of colon cancer through FAK-PI3K/AKT and MAPK pathway. Journal of Experimental & Clinical Cancer Research, 35 (1).
Zhang, H. , Zhu, Z. , Wang, D. , Yang, Y. , Wang, H. & Sun, X. (2016). Upregulation of nucleoporin 88 is associated with nodal metastasis and poor differentiation in oral squamous cell carcinoma. International Journal of Clinical and Experimental Medicine, 9 (5), 8399-8404.
Meng, W. , Yang, L. , Ma, Q. , Zhang, H. , Adell, G. , Arbman, G. , Wang, Z. , Li, Y. & et al. (2015). MicroRNA Expression Profile Reveals miR-17-92 and miR-143-145 Cluster in Synchronous Colorectal Cancer. Medicine, 94 (32).
Wang, M. , Ping, J. , Li, Y. , Holmqvist, A. , Adell, G. , Arbman, G. , Zhang, H. , Zhou, Z. & et al. (2015). Prognostic significance and molecular features of colorectal mucinous adenocarcinomas: A strobe-compliant study. Medicine, 94 (51).
Meng, W. , Pathak, S. , Ding, Z. , Zhang, H. , Adell, G. , Holmlund, B. , Li, Y. , Zhou, Z. & et al. (2015). Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer. Cancer Biology & Therapy, 16 (12), 1738-1745.
Wang, M. , Ping, J. , Li, Y. , Adell, G. , Arbman, G. , Nodin, B. , Meng, W. , Zhang, H. & et al. (2015). The prognostic factors and multiple biomarkers in young patients with colorectal cancer. Scientific Reports, 5.
Gnosa, S. , Zhang, H. , Brodin, V. P. , Carstensen, J. , Adell, G. & Sun, X. (2014). AEG-1 expression is an independent prognostic factor in rectal cancer patients with preoperative radiotherapy: a study in a Swedish clinical trial. British Journal of Cancer, 111 (1), 166-173.
Pathak, S. , Meng, W. , Zhang, H. , Gnosa, S. , Nandy, S. K. , Adell, G. , Holmlund, B. & Sun, X. (2014). Tafazzin Protein Expression Is Associated with Tumorigenesis and Radiation Response in Rectal Cancer: A Study of Swedish Clinical Trial on Preoperative Radiotherapy. PLOS ONE, 9 (5).
Wang, C. , Frayennbergh-Karlson, H. , Wang, D. , Arbman, G. , Zhang, H. & Sun, X. (2013). Clinicopathological significance of BTF3 expression in colorectal cancer. Tumor Biology, 34 (4), 2141-2146.
Ding, Z. , Zhang, H. , Adell, G. , Olsson, B. & Sun, X. (2013). Livin expression is an independent factor in rectal cancer patients with or without preoperative radiotherapy. Radiation Oncology, 8 (1).
Lööf, J. , Pfeifer, D. , Ding, Z. , Sun, X. & Zhang, H. (2012). Effects of ΔNp73β on cisplatin treatment in colon cancer cells. Molecular Carcinogenesis, 51 (8), 628-35.

Artiklar, forskningsöversikter

Nagainallur Ravichandran, S. , Das, D. , Dayananda, E. K. , Dey, A. , Banerjee, A. , Sun-Zhang, A. , Zhang, H. , Sun, X. & et al. (2024). A Review on Emerging Techniques for Diagnosis of Colorectal Cancer. Cancer Investigation, 42 (2), 119-140.
Shruthi, N. R. , Makalakshmi, M. K. , Das, A. , Banerjee, A. , Veronica, S. , Sun-Zhang, A. , Zhang, H. , Anbalagan, M. & et al. (2024). An Updated Review on Molecular Biomarkers in Diagnosis and Therapy of Colorectal Cancer. Current Cancer Drug Targets, 24 (6), 595-611.
Jain, S. M. , Nagainallur Ravichandran, S. , Murali Kumar, M. , Banerjee, A. , Sun-Zhang, A. , Zhang, H. , Pathak, R. , Sun, X. & et al. (2024). Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy: A review. Cancer Biology & Therapy, 25 (1).
Banerjee, A. , Deka, D. , Muralikumar, M. , Sun-Zhang, A. , Bisgin, A. , Christopher, C. , Zhang, H. , Sun, X. & et al. (2023). A concise review on miRNAs as regulators of colon cancer stem cells and associated signalling pathways. Clinical and Translational Oncology, 25, 3345-3356.
Banerjee, A. , Somasundaram, I. , Das, D. , Jain Manoj, S. , Banu, H. , Mitta Suresh, P. , Paul, S. , Bisgin, A. & et al. (2023). Functional Foods: A Promising Strategy for Restoring Gut Microbiota Diversity Impacted by SARS-CoV-2 Variants. Nutrients, 15 (11).
Dey, A. , Mitra, A. , Pathak, S. , Prasad, S. , Zhang, A. S. , Zhang, H. , Sun, X. & Banerjee, A. (2023). Recent Advancements, Limitations, and Future Perspectives of the use of Personalized Medicine in Treatment of Colon Cancer. Technology in Cancer Research & Treatment, 22.
Das, A. , Deka, D. , Banerjee, A. , Radhakrishnan, A. K. , Zhang, H. , Sun, X. & Pathak, S. (2022). A concise review on the role of natural and synthetically derived peptides involved in colorectal cancer. Current Topics in Medicinal Chemistry, 22 (31), 2571-2588.
Sriramulu, S. , Sun, X. , Malayaperumal, S. , Ganesan, H. , Zhang, H. , Ramachandran, M. , Banerjee, A. & Pathak, S. (2021). Emerging Role and Clinicopathological Significance of AEG-1 in Different Cancer Types: A Concise Review. Cells, 10 (6).

Konferensbidrag

Pham, T. D. , Fan, C. , Zhang, H. & Sun, X. (2019). Deep Learning of P73 Biomarker Expression in Rectal Cancer Patients. I: 2019 International Joint Conference on Neural Networks (IJCNN). Konferensbidrag vid International Joint Conference on Neural Networks (IJCNN), Budapest, Hungary, July 14-19, 2019. IEEE.
Fan, C. , Kopsida, M. , Liu, Y. , Zhang, H. , Gao, J. , Arbman, G. , Cao, S. , Li, Y. & et al. (2019). The clinical significance of MRE11 expression based on location of primary tumor in colorectal cancer patients: an integrative analysis of multi-center data. I: Cancer Research. Konferensbidrag vid Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, USA, March 29 - April 3, 2019. American Association for Cancer Research Inc..
Gnosa, S. , Brodin, V. P. , Ticha, I. , Adell, G. , Arbman, G. , Zhang, H. & Sun, X. (2014). Genetic variants and expression of AEG-1 in relation to clinical outcome and radiotherapy response in colorectal cancer patients and cell lines. I: Cancer Research. Konferensbidrag vid 105th Annual Meeting of the American-Association-for-Cancer-Research (AACR), San Diego, CA, USA, April 5-9, 2014.

Manuskript

Xueli, Z. , Zhang, H. , Fan, C. , Haapaniemi, S. , Shen, B. & Sun, X. Loss of CHGA protein as a potential biomarker for colon cancer diagnosis : a study on biomarker discovery by machine learning and confirmation by immunohistochemistry in colorectal cancer tissue microarrays.
Evert, J. , Pathak, S. , Sun, X. & Zhang, H. Modification of microRNA expression profiles by oxaliplatin, p53 and p73 in human colon cancer cells in vitro.