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Julia König

Tjänstetitel: Universitetslektor Organisation: Institutionen för medicinska vetenskaper

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Telefon: 019 303645

Rum: C2106

Julia König

Om Julia König

Julia König joined the NGBI research centre as a postdoctoral researcher in December 2012. She received a Master’s degree in nutrition science in 2008 from the University of Hohenheim in Germany and graduated from the international PhD program ‘Molecular Medicine’ from the Medical University of Graz, Austria in 2011. The topic of her PhD thesis was ‘Endothelial differentiation potential of amnion-derived mesenchymal stromal cells’, in which she investigated a potential therapeutic use of human placenta-derived cells in vascular biology. After her PhD, she worked as a postdoctoral researcher for the Department of Obstetrics and Gynaecology at the Medical University of Graz for the project ‘Detection of biomarkers for preterm birth in saliva and cervico-vaginal fluid of pregnant women using proteomics’.

As part of the NGBI group, she is now combining her background in nutrition science with her interest in translational clinical research. With her research she is investigating the interactions between nutrition, gut microbiota, the gut and the brain, and tries to find new treatments for gastrointestinal disorders such as irritable bowel syndrome (IBS).

One of Julia’s main projects is to investigate the potential of faecal microbiota transfer (FMT) in disorders/diseases such as IBS and microscopic colitis. FMT aims at re-establishing a healthy gut microbiota by infusing suspended stool from a healthy donor into the intestine of the patients. In addition, she is involved in human studies investigating the effects and modes of action of probiotics, the human gut barrier function as well as the gut-brain axis (fMRI studies). 

Forskargrupper

Publikationer

Artiklar i tidskrifter |  Artiklar, forskningsöversikter |  Kapitel i böcker, del av antologier |  Konferensbidrag |  Manuskript | 

Artiklar i tidskrifter

Rode, J. , Yang, L. , König, J. , Hutchinson, A. , Wall, R. , Venizelos, N. , Brummer, R. J. , Rangel, I. & et al. (2020). Butyrate Rescues Oxidative Stress-Induced Transport Deficits of Tryptophan: Potential Implication in Affective or Gut-Brain Axis Disorders. Neuropsychobiology, 1-11.
Holster, S. , Rode, J. , Bohr, J. , Kumawat, A. K. , Veress, G. , Hultgren Hörnquist, E. , Brummer, R. J. & König, J. (2020). Faecal microbiota transfer in patients with microscopic colitis: a pilot study in collagenous colitis. Scandinavian Journal of Gastroenterology, 1-13.
König, J. & Brummer, R. J. (2020). Faecal microbiota transplantation in IBS - new evidence for success?. Nature Reviews. Gastroenterology & Hepatology.
Holster, S. , Hooiveld, G. J. , Repsilber, D. , de Vos, W. , Brummer, R. J. & König, J. (2019). Allogenic Faecal Microbiota Transfer Induces Immune-Related Gene Sets in the Colon Mucosa of Patients with Irritable Bowel Syndrome. Biomolecules, 9 (10).
Holster, S. , Lindqvist, C. M. , Repsilber, D. , Salonen, A. , de Vos, W. , König, J. & Brummer, R. J. (2019). The Effect of Allogenic Versus Autologous Fecal Microbiota Transfer on Symptoms, Visceral Perception and Fecal and Mucosal Microbiota in Irritable Bowel Syndrome: A Randomized Controlled Study. Clinical and Translational Gastroenterology, 10 (4).
König, J. & Brummer, R. J. (2018). Is an enzyme supplement for celiac disease finally on the cards?. Expert Review of Gastroenterology & Hepatology, 12 (6), 531-533.
König, J. , Siebenhaar, A. , Högenauer, C. , Arkkila, P. , Nieuwdorp, M. , Norén, T. , Ponsioen, C. Y. , Rosien, U. & et al. (2017). Consensus report: Faecal microbiota transfer - clinical applications and procedures. Alimentary Pharmacology and Therapeutics, 45 (2), 222-239.
König, J. , Lang, I. , Siwetz, M. , Fröhlich, J. & Huppertz, B. (2014). Amnion-derived mesenchymal stromal cells show a mesenchymal-epithelial phenotype in culture.. Cell and Tissue Banking, 15 (2), 193-198.
Kinzer, M. , Hingerl, K. , König, J. , Reinisch, A. , Strunk, D. , Huppertz, B. & Lang, I. (2014). Mesenchymal stromal cells from the human placenta promote neovascularization in a mouse model in vivo.. Placenta, 35 (7), 517-519.
König, J. , Weiss, G. , Rossi, D. , Wankhammer, K. , Reinisch, A. , Kinzer, M. , Huppertz, B. , Pfeiffer, D. & et al. (2014). Placental Mesenchymal Stromal Cells Derived from Blood Vessels or Avascular Tissues: What Is the Better Choice to Support Endothelial Cell Function?. Stem Cells and Development, 24 (1), 115-131.
König, J. , Rangel, I. & Brummer, R. J. (2013). The Role of Lactic Acid Bacteria in the Pathophysiology and Treatment of Irritable Bowel Syndrome (IBS). Food and Nutrition Sciences, 4 (11), 27-39.
König, J. , Huppertz, B. , Desoye, G. , Parolini, O. , Fröhlich, J. D. , Weiss, G. , Dohr, G. , Sedlmayr, P. & et al. (2012). Amnion-derived mesenchymal stromal cells show angiogenic properties but resist differentiation into mature endothelial cells. Stem Cells and Development, 21 (8), 1309-1320.
Fröhlich, J. D. , Huppertz, B. , Abuja, P. M. , König, J. & Desoye, G. (2012). Oxygen modulates the response of first-trimester trophoblasts to hyperglycemia. American Journal of Pathology, 180 (1), 153-164.
Huppertz, B. , Gauster, M. , Orendi, K. , König, J. & Moser, G. (2009). Oxygen as modulator of trophoblast invasion. Journal of Anatomy, 215 (1), 14-20.

Artiklar, forskningsöversikter

König, J. , Wells, J. , Cani, P. D. , García-Ródenas, C. L. , MacDonald, T. , Mercenier, A. , Whyte, J. , Troost, F. & et al. (2016). Human Intestinal Barrier Function in Health and Disease. Clinical and Translational Gastroenterology, 7 (10).

Kapitel i böcker, del av antologier

Marques, T. M. , Holster, S. , Wall, R. , König, J. & Brummer, R. J. (2016). Correlating the gut microbiome to health and disease. I: Niall Hyland, Catherine Stanton, The Gut-Brain Axis: Dietary, Probiotic, and Prebiotic Interventions on the Microbiota (ss. 261-291). . Elsevier.
König, J. , Ganda-Mall, J. , Rangel, I. , Edebol-Carlman, H. & Brummer, R. J. (2015). The Role of the Gut Microbiota in Brain Function. I: Koen Venema & Ana Paula do Carmo, Probiotics and Prebiotics: Current Research and Future Trends. Poole, UK: Caister Academic Press.
König, J. & Brummer, R. (2014). Modulation of the gut ecosystem in irritable bowel syndrome. I: Gert Folkerts, Johan Garssen, Pharma-Nutrition: an overview (ss. 55-73). . Springer.

Konferensbidrag

Edebol-Carlman, H. , Rode, J. , König, J. , Hutchinson, A. , Repsilber, D. , Kiselev, A. , Thunberg, P. , Lathrop Stern, L. & et al. (2019). Evaluating the effects of probiotic intake on brain activity during an emotional attention task and blood markers related to stress in healthy subjects. Konferensbidrag vid Mind, Mood & Microbes, 2nd International Conference on Microbiota-Gut-Brain Axis, Amsterdam, The Netherlands, 17-18 January, 2019.
König, J. , Holster, S. , Bruins, M. & Brummer, R. J. (2017). Aspergillus Niger-Derived Enzyme Degrades Gluten in the Stomach of Gluten-Sensitive Subjects. I: 2017 DDW Abstracts. Konferensbidrag vid Digestive Disease Week (DDW), Chicago, IL, USA, May 6-9, 2017 (ss. S481-S481). Saunders Elsevier.
König, J. , Holster, S. , Bruins, M. & Brummer, R. J. (2017). Effective gluten degradation in non-coeliac gluten-sensitive subjects by Aspergillus Niger derived enzyme: A placebo-controlled randomized clinical trial. Konferensbidrag vid United European Gastroenterology (UEG) Week, Barcelona (Oct 28-Nov 1, 2017) (ss. A28-. Sage Publications.
Holster, S. , Repsilber, D. , Brummer, R. J. & König, J. (2017). Faecal microbiota transfer in irritable bowel syndrome: clinical outcomes of a randomised placebo-controlled trial. I: UEG Week 2017 Oral Presentations. Konferensbidrag vid United European Gastroenterology (UEG) Week, Barcelona, Spain, October 28 - November 1, 2017 (ss. A155-A156). Sage Publications.
Holster, S. , Brummer, R. J. , Repsilber, D. & König, J. (2017). Fecal Microbiota Transplantation in Irritable Bowel Syndrome and a Randomized Placebo-Controlled Trial. I: 2017 DDW Abstracts. Konferensbidrag vid Digestive Disease Week (DDW), Chicago, IL, USA, May 6-9, 2017 (ss. S101-S102). Saunders Elsevier.

Manuskript

Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Salonen, A. , Lindqvist, C. M. , Rajan, S. K. , De Vos, W. M. & et al. Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome.
Holster, S. , Repsilber, D. , Geng, D. , Hyötyläinen, T. , Lindqvist, C. M. , de Vos, W. , Brummer, R. J. & König, J. Faecal microbiota transfer in irritable bowel syndrome results inaltered correlations between the gut microbiota and its metabolites.
Holster, S. , Rode, J. , Bohr, J. , Kumawat, A. K. , Hultgren Hörnquist, E. , Brummer, R. J. & König, J. Faecal microbiota transfer in patients with microscopic colitis : A proof-of-concept study in collagenous colitis.