Wessam Melik
Befattning: Universitetslektor Organisation: Institutionen för medicinska vetenskaperE-post: wessam.melik@oru.se
Telefon: 019 301307
Rum: X5508

Forskningsämne
Forskningsprojekt
Pågående projekt
- Developvaccines@oru
- Molekylär epidemiologi för fästing-buren encefalitvirus (TBE)
- Nya peptidläkemedel mot infektioner orsakade av höljeförsedda virus
- Nya Prime-Boost-strategier för DNA lanserade suicidala flavivirusvaccin
Avslutade projekt
Forskargrupper
Publikationer
Artiklar i tidskrifter |
Artiklar, forskningsöversikter |
Konferensbidrag |
Manuskript |
Artiklar i tidskrifter
- Tran, P. T. H. , Höglund, U. , Larsson, O. , Appelberg, S. , Mirazimi, A. , Johansson, M. & Melik, W. (2022). Enhanced Seroconversion to West Nile Virus Proteins in Mice by West Nile Kunjin Replicon Virus-like Particles Expressing Glycoproteins from Crimean-Congo Hemorrhagic Fever Virus. Pathogens, 11 (2).
- Omer, A. A. M. , Hinkula, J. , Tran, P. T. H. , Melik, W. , Zattarin, E. , Aili, D. , Selegård, R. , Bengtsson, T. & et al. (2022). Plantaricin NC8 αβ rapidly and efficiently inhibits flaviviruses and SARS-CoV-2 by disrupting their envelopes. PLOS ONE, 17 (11).
- Tran, P. T. H. , Chiramel, A. I. , Johansson, M. & Melik, W. (2022). Roles of ESCRT Proteins ALIX and CHMP4A and Their Interplay with Interferon-Stimulated Gene 15 during Tick-Borne Flavivirus Infection. Journal of Virology, 96 (3).
- Asghar, N. , Melik, W. , Paulsen, K. M. , Pedersen, B. N. , Bø-Granquist, E. G. , Vikse, R. , Stuen, S. , Andersson, S. & et al. (2022). Transient Expression of Flavivirus Structural Proteins in Nicotiana benthamiana . Vaccines, 10 (10).
- Tran, P. , Asghar, N. , Johansson, M. & Melik, W. (2021). Roles of the Endogenous Lunapark Protein during Flavivirus Replication. Viruses, 13 (7).
- Tran, P. T. H. , Asghar, N. , Höglund, U. , Larsson, O. , Haag, L. , Mirazimi, A. , Johansson, M. & Melik, W. (2020). Development of a Multivalent Kunjin Virus Reporter Virus-Like Particle System Inducing Seroconversion for Ebola and West Nile Virus Proteins in Mice. Microorganisms, 8 (12).
- Mlera, L. , Melik, W. , Offerdahl, D. K. , Dahlstrom, E. , Porcella, S. F. & Bloom, M. E. (2016). Analysis of the Langat Virus Genome in Persistent Infection of an Ixodes scapularis Cell Line. Viruses, 8 (9).
- Asghar, N. , Lee, Y. , Nilsson, E. , Lindqvist, R. , Melik, W. , Kröger, A. , Överby, A. K. & Johansson, M. (2016). The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus. Scientific Reports, 6.
- Asghar, N. , Lindblom, P. , Melik, W. , Lindqvist, R. , Haglund, M. , Forsberg, P. , Överby, A. K. , Andreassen, Å. & et al. (2014). Tick-Borne Encephalitis Virus Sequenced Directly from Questing and Blood-Feeding Ticks Reveals Quasispecies Variance. PLOS ONE, 9 (7).
- Wigerius, M. , Asghar, N. , Melik, W. & Johansson, M. (2013). Scribble controls NGF-mediated neurite outgrowth in PC12 cells. European Journal of Cell Biology, 92 (6-7), 213-221.
- Bertrand, Y. , Töpel, M. , Elväng, A. , Melik, W. & Johansson, M. (2012). First dating of a recombination event in mammalian tick-borne flaviviruses. PLOS ONE, 7 (2).
- Melik, W. , Ellencrona, K. , Wigerius, M. , Hedström, C. , Elväng, A. & Johansson, M. (2012). Two PDZ binding motifs within NS5 have roles in Tick-borne encephalitis virus replication. Virus Research, 169 (1), 54-62.
- Elväng, A. , Melik, W. , Bertrand, Y. , Lönn, M. & Johansson, M. (2011). Sequencing of a tick-borne encephalitis virus from Ixodes ricinus reveals a thermosensitive RNA switch significant for virus propagation in ectothermic arthropods. Vector Borne and Zoonotic Diseases, 11 (6), 649-658.
Artiklar, forskningsöversikter
- Kellman, E. M. , Offerdahl, D. K. , Melik, W. & Bloom, M. E. (2018). Viral Determinants of Virulence in Tick-Borne Flaviviruses. Viruses, 10 (6).
Konferensbidrag
- Alim, A. , Pelli, F. , Asghar, N. , Melik, W. & Johansson, M. (2023). Tick-borne encephalitis virus protein expression to develop novel subunit vaccines and diagnostic tools. Konferensbidrag vid 20th Smögen Summer Symposium on Virology, Smögen, Sweden, August 24-26, 2023.
- Tran, P. T. H. , Asghar, N. , Karlsson, R. , Karlsson, A. , Johansson, M. & Melik, W. (2019). Identification and characterization of host proteins inducing the endoplasmic reticulum invagination during Flavivirus infection. I: Positive-Strand RNA Viuses. Konferensbidrag vid Positive-Strand RNA Viuses, KILLARNEY, Co.Kerry, Ireland, June 9-13,2019. (ss. 280-280).
- Johansson, M. , Frelin, L. , Maravelia, P. , Asghar, N. , Melik, W. , Caro-Perez, N. , Pasetto, A. , Ahlen, G. & et al. (2019). Immunogenicity of a New Flaviviral-Based DNA Launched Suicidal Replicon for Protective Vaccination Against Hepatitis C. I: Molecular Therapy. Konferensbidrag vid 22nd Annual Meeting of the American-Society-of-Gene-and-Cell-Therapy (ASGCT), Washington, DC, USA, April 29 - May 2, 2019,. (ss. 139-139). Cell Press.
- Asghar, N. , Maravelia, P. , Caro-Perez, N. , Tran, P. T. H. , Melik, W. , Pasetto, A. , Ahlen, G. , Frelin, L. & et al. (2019). Immunogenicity of DNA launched suicidal flavivirus replicons for protective vaccination against hepatitis viruses. Konferensbidrag vid 16th Smögen Summer Symposium on Virology, Smögen, Sweden, August 22-24, 2019.
- Asghar, N. , Maravelia, P. , Caro-Perez, N. , Tran, H. , Melik, W. , Pasetto, A. , Ahlen, G. , Frelin, L. & et al. (2019). Immunogenicity of DNA launched suicidal flavivirus replicons for protective vaccination against hepatitis viruses. Konferensbidrag vid Positive-Strand RNA Viruses (E2), Killarney, Co. Kerry Ireland, June 9-13, 2019.
- Tran, P. T. H. , Asghar, N. , Karlsson, R. , Karlsson, A. , Johansson, M. & Melik, W. (2019). Screening of host proteins interacting with Kunjin, Langat, Zika replication complex. I: Positive-Strand Rna Viuses. Konferensbidrag vid Positive-Strand RNA Viuses, KILLARNEY, Co.Kerry, Ireland, June 9-13,2019.
- Tran, P. T. H. , Asghar, N. , Karlsson, A. , Karlsson, R. , Johansson, M. & Melik, W. (2019). Screening of host proteins interacting with Kunjin, Langat, Zikareplication complex. I: 16th Smögen Summer Symposium on Virology. Konferensbidrag vid 16th Smögen Summer Symposium on Virology, Smögen, Sweden, August 22-24, 2019.
- Asghar, N. , Gunaltay, S. , Tran, P. T. H. , Melik, W. , Höglund, U. , Johansson, C. , Frelin, L. , Sällberg, M. & et al. (2018). DNA launched suicidal flaviviruses as therapeutic vaccine candidates. Konferensbidrag vid 15th Smögen Summer Symposium on Virology, Smögen, Sweden, August 23-25, 2018.
Manuskript
- Tran, P. , Karlsson, R. , Karlsson, A. , Asghar, N. , Melik, W. & Johansson, M. Proteomic screening identifies TRIM21 and TRIM14 as antiviral proteins against Langat virus and Zika virus.