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Thomas Chaillou

Tjänstetitel: Universitetslektor Organisation: Institutionen för hälsovetenskaper

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Telefon: 019 303460

Rum: G2108

Thomas Chaillou

Om Thomas Chaillou

Thomas Chaillou är universitetslektor i idrottsfysiologi.

Under 2011 tog han sin doktorsexamen (University of Grenoble, Frankrike) i muskelremodulering, under hypertrofi och regenerering i hypoxi. Mellan 2012 och 2014 var han postdoktor vid University of Kentucky (USA) där han fortsatte att utveckla sin expertis inom mekanismer för att kontrollera skelettmuskelmassa. Mellan 2014 och 2016 var han postdoktor vid Karolinska Institutet där han fokuserade sin forskning på muskelfunktion (kraft, trötthet, återhämtning) under fysiologiska (t.ex. fysisk aktivitet) och patologiska (t.ex. cancer, kemoterapi, ALS och ischemi) förhållanden. Han blev universitetslektor vid Örebro universitet 2016.

Hans nuvarande forskning är uppdelad i tre delar: 1) muskel- och molekylärbiologi under fysiologiska (t.ex. träning, åldrande, termisk stress) och patologiska (t.ex. inflammation) tillstånd, 2) återhämtningsstrategier inom idrott och 3) fysiologiska förändringar och anpassningar till träning.

Hans undervisning fokuserar främst på träningsfysiologi, idrottsprestation, idrottsnutrition, forskningsmetoder inom idrottsvetenskap och fysiologiska / biologiska metoder som tillämpas på idrottsvetenskap. Han är handledare till studenter på kandidat och masternivå, samt är ansvarig för flera kurser.

Publikationer

Artiklar i tidskrifter |  Artiklar, forskningsöversikter |  Konferensbidrag | 

Artiklar i tidskrifter

Cheng, A. J. , Chaillou, T. , Kamandulis, S. , Subocius, A. , Westerblad, H. , Brazaitis, M. & Venckunas, T. (2020). Carbohydrates do not accelerate force recovery after glycogen-depleting followed by high-intensity exercise in humans. Scandinavian Journal of Medicine and Science in Sports, 30 (6), 998-1007.
Chaillou, T. & Treigyte, V. (2020). Cold water immersion puts the chill on muscle protein synthesis after resistance exercise. Journal of Physiology, 598 (6), 1123-1124.
Chaillou, T. , Sanna, I. & Kadi, F. (2020). Glutamine-stimulated in vitro hypertrophy is preserved in muscle cells from older women. Mechanisms of Ageing and Development, 187.
Cheng, A. J. , Allodi, I. , Chaillou, T. , Schlittler, M. , Ivarsson, N. , Lanner, J. T. , Thams, S. , Hedlund, E. & et al. (2019). Intact single muscle fibres from SOD1(G93A) amyotrophic lateral sclerosis mice display preserved specific force, fatigue resistance and training-like adaptations. Journal of Physiology, 597 (12), 3133-3146.
Vechetti, I. J. , Wen, Y. , Chaillou, T. , Murach, K. A. , Alimov, A. P. , Figueiredo, V. C. , Dal-Pai-Silva, M. & McCarthy, J. J. (2019). Life-long reduction in myomiR expression does not adversely affect skeletal muscle morphology. Scientific Reports, 9 (1).
Ferreira, D. M. S. , Cheng, A. J. , Agudelo, L. Z. , Cervenka, I. , Chaillou, T. , Correia, J. C. , Porsmyr-Palmertz, M. , Izadi, M. & et al. (2019). LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force. Skeletal Muscle, 9 (1).
Chaillou, T. & Cheng, A. J. (2019). Mechanisms of prolonged low-frequency force depression: in-vivo studies get us closer to the truth. American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 316 (5), R502-R503.
Rantala, R. & Chaillou, T. (2019). Mild hypothermia affects the morphology and impairs glutamine-induced anabolic response in human primary myotubes. American Journal of Physiology - Cell Physiology, 317 (1), C101-C110.
Cheng, A. , Allodi, I. , Chaillou, T. , Thams, S. , Ivarsson, N. , Schlittler, M. , Lanner, J. , Hedlund, E. & et al. (2017). Increased fatigue resistance and preserved specific force in intact single muscle fibres from the SOD1G93A mouse model of ALS. Acta Physiologica, 219 (S710), 17-17.
Cheng, A. J. , Willis, S. J. , Zinner, C. , Chaillou, T. , Ivarsson, N. , Ørtenblad, N. , Lanner, J. T. , Holmberg, H. & et al. (2017). Post-exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle. Journal of Physiology, 595 (24), 7413-7426.
Chaillou, T. , Zhang, X. & McCarthy, J. J. (2016). Expression of Muscle-Specific Ribosomal Protein L3-Like Impairs Myotube Growth. Journal of Cellular Physiology, 231 (9), 1894-1902.
Chaillou, T. & Cheng, A. J. (2016). Integrative biology is needed to understand exercise adaptions from the whole body to the cellular level. Journal of applied physiology, 121 (2), 598-599.
Chaillou, T. , Hynynen, H. , Ferreira, D. , Pironti, G. , Kenne, E. , Andersson, D. C. , Ruas, J. L. , Tavi, P. & et al. (2016). NDUFA4L2: Connecting metabolic signals and mitochondrial function in cardiac and skeletal muscle. Free Radical Biology & Medicine, 100 (Suppl.), S186-S186.
Kirby, T. , Lee, J. , England, J. , Chaillou, T. , Esser, K. & McCarthy, J. (2015). Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis. Journal of applied physiology, 119 (4), 321-327.
Chaillou, T. , Jackson, J. , England, J. , Kirby, T. , Richards-White, J. , Esser, K. , Dupont-Versteegden, E. & McCarthy, J. (2015). Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowth. Journal of applied physiology, 118, 86-97.
Kirby, T. , Chaillou, T. & McCarthy, J. (2015). The role of microRNAs in skeletal muscle health and disease. Frontiers in Bioscience, 20, 37-77.
Chaillou, T. , Koulmann, N. , Meunier, A. , Pugnière, P. , McCarthy, J. , Beaudry, M. & Bigard, X. (2014). Ambient hypoxia enhances the loss of muscle mass after extensive injury. Pflügers Archiv: European Journal of Physiology, 466 (3), 587-598.
Chaillou, T. , Koulmann, N. , Meunier, A. , Chapot, R. , Serrurier, B. , Beaudry, M. & Bigard, X. (2014). Effect of hypoxia exposure on the recovery of skeletal muscle phenotype during regeneration. Molecular and Cellular Biochemistry, 390 (1-2), 31-40.
Chaillou, T. , Koulmann, N. , Meunier, A. , Malgoyre, A. , Serrurier, B. , Beaudry, M. & Bigard, X. (2013). Effect of hypoxia exposure on the phenotypic adaptation in remodelling skeletal muscle submitted to functional overload. Acta Physiologica, 209 (4), 272-282.
Chaillou, T. , Koulmann, N. , Simler, N. , Meunier, A. , Serrurier, B. , Chapot, R. , Peinnequin, A. , Beaudry, M. & et al. (2012). Hypoxia transiently affects skeletal muscle hypertrophy in a functional overload model. American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 302, R643-R654.
Malgoyre, A. , Sanchez, H. , Tonini, J. , Serrurier, B. , Prola, A. , Chaillou, T. , Simler, N. & Bigard, X. (2011). Aerobic performance improvment and mitochondrial adaptations after endurance training in hypoxia. Acta Physiologica, 202 (Suppl. 685).
Chaillou, T. , Koulmann, N. , Simler, N. , Meunier, A. , Grégoire, C. , Serrurier, B. , Beaudry, M. & Bigard, X. (2011). Ambient hypoxia enhances the muscle-mass loss after extensive injury. The FASEB Journal, 25 (1 Suppl.).
Chaillou, T. , Malgoyre, A. , Banzet, S. , Chapot, R. , Koulmann, N. , Pugnière, P. , Beaudry, M. , Bigard, X. & et al. (2011). Pitfalls in target mRNA quantification for real-time quantitative RT-PCR in overload-induced skeletal muscle hypertrophy. Physiological Genomics, 43 (4), 228-235.
Pugnière, P. , Banzet, S. , Chaillou, T. , Mouret, C. & Peinnequin, A. (2011). Pitfalls of reverse transcription quantitative polymerase chain reaction standardization: Volume-related inhibitors of reverse transcription. Analytical Biochemistry, 415 (2), 151-157.

Artiklar, forskningsöversikter

Konferensbidrag

Lanner, J. , Mader, T. , Chaillou, T. , Cheng, A. , Steinz, M. , Zhengye, L. , Rundqvist, H. & Kenne, E. (2019). Running reverses tumor-induced muscle weakness in mice with breast cancer. Konferensbidrag vid The Scandinavian Physiological Society Annual Meeting (SPS 2019), Reykjavik, Iceland, August 9-11, 2019.
Rantala, R. , Kadi, F. & Chaillou, T. (2018). Low temperature affects the morphology and impairs glutamine-induced hypertrophic response in human primary myotubes. Konferensbidrag vid Europhysiology, London, UK, September 14-16, 2018.
Mader, T. , Kenne, E. , Chaillou, T. , Petkovic, M. , Steinz, M. , Liu, Z. , Kalakoutis, M. & Lanner, J. (2018). Metabolic alteration and muscle dysfunction in mice with breast cancer. Konferensbidrag vid Europhysiology, London, UK, September 14-16, 2018.
Ferreira, D. , Cheng, A. , Edsgärd, D. , Chaillou, T. , Porsmyr-Palmertz, M. , da Silva, P. , Izadi, M. , Agudelo, L. & et al. (2017). LMCD1B: A novel regulator of skeletal muscle metabolism. Konferensbidrag vid Cell Symposia: Exercise Metabolism, Göteborg, Sweden, May 21-23, 2017.
Chaillou, T. , Hynynen, H. , Ferreira, D. , Pironti, G. , Andersson, D. , Ruas, J. , Tavi, P. & Lanner, J. (2016). The mitochondrial NDUFA4L2 protein: a novel modulator of skeletal muscle mass and force. Konferensbidrag vid The Scandinavian Physiological Society Annual Meeting, Oslo, Norway, August 26-28, 2016.
Chaillou, T. , Ivarsson, N. , Mijwel, S. , Cheng, A. , Rundqvist, H. & Lanner, J. (2015). Breast-cancer-induced muscle weakness: benefits of physical exercise to restore muscle function. Konferensbidrag vid Excitation-contraction coupling Gordon research Conference, Maine, USA, May 31- June 5, 2015.
Chaillou, T. , Zhang, X. & McCarthy, J. (2014). Muscle-specific Ribosomal Protein L3-like Inhibits Myotube Growth. Konferensbidrag vid 2014 ACSM Annual Meeting, Orlando, USA, May 27-31, 2014.
Pugnière, P. , Banzet, S. , Chaillou, T. , Mouret, C. & Peinnequin, A. (2012). Volume-related inhibitors standardization for reverse transcription quantitative polymerase chain reaction experiments. Konferensbidrag vid Congress of Genomics Research, Boston, USA, April 19-20, 2012.
Simler, N. , Meunier, A. , Chaillou, T. , Gangloff, K. & Bigard, X. (2011). Activating AMPK signalling in hypothalamus supresses hypoxia-induced hypophagia in rats. Konferensbidrag vid Congress of Physiology, Pharmacology, and Therapeutics, Grenoble, France, March 22-24, 2011.
Chaillou, T. , Koulmann, N. , Simler, N. , Meunier, A. , Grégoire, C. , Chapot, R. , Serrurier, B. , Beaudry, M. & et al. (2011). Ambient hypoxia enhances the muscle-mass loss after extensive injury. Konferensbidrag vid 4th Congress of Myology, Lille, France, May 9-13, 2011.
Chaillou, T. , Koulmann, N. , Simler, N. , Serrurier, B. , Meunier, A. , Chapot, R. , Peinnequin, A. , Beaudry, M. & et al. (2011). Ambient hypoxia transiently affects muscle growth in a functional overload model in rats. Konferensbidrag vid Physiology, Pharmacology and Therapeutics , P2T 2011, Grenoble, France, March 23rd, 2011.
Chaillou, T. , Koulmann, N. , Beaudry, M. & Bigard, X. (2011). Molecular mechanisms involved in the muscle mass control. Konferensbidrag vid 14th Congress of Sports and Physical Activities Researchers Association (ACAPS), Rennes, France, October, 2011.
Chaillou, T. , Koulmann, N. , Simler, N. , Serrurier, B. , Meunier, A. , Chapot, R. , Peinnequin, A. , Beaudry, M. & et al. (2010). Ambient hypoxia transiently affects muscle growth in a functional overload model in rats. Konferensbidrag vid Annual Congress of the European Congress of Sport Science, Antalya, Turkey, 23-26 June 2010.
Bigard, X. , Chaillou, T. , Sanchez, H. , Malgoyre, A. & Koulmann, N. (2010). How to build high oxidative skeletal muscle?: Interaction between energy stress and muscle growth. Konferensbidrag vid 15th Annual European Congress of Sport Science (ECSS 2010), Antalya, Turkey, June 23-26, 2010.