Magnus Grenegård

Artiklar i tidskrifter

• Pournara, D. T. , Fotopoulou, T. , Paramel Varghese, G. , Lindkvist, M. , Grenegård, M. , Fransén, K. & Koufaki, M. (2026). Design and Synthesis of Novel Purine Analogues as Potential IL-1β Inhibitors Targeting Vascular Inflammation.  Chemistry and Biodiversity, 23 (1). [BibTeX]
• Haug, M. , Fransén, K. , Pournara, D. T. , Fotopoulou, T. , Kritsi, E. , Ifanti, E. , Ansari, S. , Lindström, E. G. & et al. (2026). The antiplatelet activity of 6-piperazinyl-purine analogues bearing nitrate esters is determined by the length of the carbon side chain.  European Journal of Pharmacology, 1026. [BibTeX]
• Jedlina, L. , Paramel Varghese, G. , Soboleva, S. , Chutna Olin, O. , Haug, M. , Fransén, K. , Lindstam, M. , Brewinska-Olchowik, M. & et al. (2025). Antithrombotic but not anticoagulant activity of the thrombin-binding RNA aptamer Apta-1.  British Journal of Pharmacology, 182 (6), 1358-1376. [BibTeX]
• Zegeye, M. M. , Matic, L. , Lengquist, M. , Hayderi, A. , Grenegård, M. , Hedin, U. , Sirsjö, A. , Ljungberg, L. U. & et al. (2023). Interleukin-6 trans-signaling induced laminin switch contributes to reduced trans-endothelial migration of granulocytic cells.  Atherosclerosis, 371, 41-53. [BibTeX]
• Wenglén, C. , Demirel, I. , Göthlin Eremo, A. , Grenegård, M. & Paramel Varghese, G. (2023). Targeting serotonin receptor 2B inhibits TGFβ induced differentiation of human vascular smooth muscle cells.  European Journal of Pharmacology, 944. [BibTeX]
• Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. & Ramström, S. (2022). Dynamic Changes in Pentraxin-3 and Neprilysin in ST Segment Elevation Myocardial Infarction.  Biomedicines, 10 (2). [BibTeX]
• Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. & Ramström, S. (2022). Levels of soluble tumor necrosis factor receptor 1 and 2 are associated with survival after ST segment elevation myocardial infarction.  Scientific Reports, 12 (1). [BibTeX]
• Paramel Varghese, G. , Lindkvist, M. , Idosa, B. A. , Sebina, L. S. , Kardeby, C. , Fotopoulou, T. , Pournara, D. , Kritsi, E. & et al. (2022). Novel purine analogues regulate IL-1β release via inhibition of JAK activity in human aortic smooth muscle cells.  European Journal of Pharmacology, 929. [BibTeX]
• Lindkvist, M. , Zegeye, M. M. , Grenegård, M. & Ljungberg, L. (2022). Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells.  International Journal of Molecular Sciences, 23 (3). [BibTeX]
• Lunde, N. N. , Gregersen, I. , Ueland, T. , Shetelig, C. , Holm, S. , Kong, X. Y. , Michelsen, A. E. , Otterdal, K. & et al. (2020). Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.  Atherosclerosis, 296, 74-82. [BibTeX]
• Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. (2019). A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition.  European Journal of Pharmacology, 857. [BibTeX]
• Fälker, K. , Ljungberg, L. , Kardeby, C. , Lindkvist, M. , Sirsjö, A. & Grenegård, M. (2019). Adrenoceptor α_2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation.  Cellular Signalling, 59, 96-109. [BibTeX]
• Befekadu, R. , Christiansen, K. , Larsson, A. & Grenegård, M. (2019). Increased plasma cathepsin S and trombospondin-1 in patients with acute ST-segment elevation myocardial infarction.  Cardiology Journal, 26 (4), 385-393. [BibTeX]
• Lindkvist, M. , Fernberg, U. , Ljungberg, L. , Fälker, K. , Fernström, M. , Hurtig-Wennlöf, A. & Grenegård, M. (2019). Individual variations in platelet reactivity towards ADP, epinephrine, collagen and nitric oxide, and the association to arterial function in young, healthy adults.  Thrombosis Research, 174, 5-12. [BibTeX]
• Kardeby, C. , Fälker, K. , Haining, E. J. , Criel, M. , Lindkvist, M. , Barroso, R. , Påhlsson, P. , Ljungberg, L. & et al. (2019). Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.  Blood Advances, 3 (3), 275-287. [BibTeX]
• Zegeye, M. M. , Lindkvist, M. , Fälker, K. , Kumawat, A. K. , Paramel Varghese, G. , Grenegård, M. , Sirsjö, A. & Ljungberg, L. U. (2018). Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells.  Cell Communication and Signaling, 16 (1). [BibTeX]
• Tengdelius, M. , Kardeby, C. , Fälker, K. , Griffith, M. , Påhlsson, P. , Konradsson, P. & Grenegård, M. (2017). Fucoidan-Mimetic Glycopolymers as Tools for Studying Molecular and Cellular Responses in Human Blood Platelets.  Macromolecular Bioscience, 17 (2). [BibTeX]
• Donner, L. , Fälker, K. , Gremer, L. , Klinker, S. , Pagani, G. , Ljungberg, L. U. , Lothmann, K. , Rizzi, F. & et al. (2016). Platelets contribute to amyloid-β aggregation in cerebral vessels through integrin αIIbβ3-induced outside-in signaling and clusterin release.  Science Signaling, 9 (429). [BibTeX]
• Sodergren, A. L. , Holm, A. B. S. , Ramström, S. , Lindström, E. G. , Grenegård, M. & Öllinger, K. (2016). Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances.  Platelets, 27 (1), 86-92. [BibTeX]
• Holm, A. B. S. , Grenegård, M. , Ollinger, K. & Lindström, E. G. (2014). Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function.  Platelets, 25 (2), 111-117. [BibTeX]
• Tengdelius, M. , Lee, C. , Grenegård, M. , Griffith, M. , Påhlsson, P. & Konradsson, P. (2014). Synthesis and Biological Evaluation of Fucoidan-Mimetic Glycopolymers through Cyanoxyl-Mediated Free-Radical Polymerization.  Biomacromolecules, 15 (7), 2359-2368. [BibTeX]
• Peng, X. , Ramström, S. , Kurz, T. , Grenegård, M. & Segelmark, M. (2014). The neutrophil serine protease PR3 induces shape change of platelets via the Rho/Rho kinase and Ca2+ signaling pathways.  Thrombosis Research, 134 (2), 418-425. [BibTeX]
• Fälker, K. , Klarström-Engström, K. , Bengtsson, T. , Lindahl, T. L. & Grenegård, M. (2014). The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLC gamma 2 signalling cascade.  Cellular Signalling, 26 (2), 279-286. [BibTeX]
• Boknäs, N. , Faxälv, L. , Sanchez Cenellas, D. , Wallstedt, M. , Ramström, S. , Grenegård, M. & Lindahl, T. L. (2014). Thrombin-induced platelet activation via PAR4: pivotal role for exosite II.  Thrombosis and Haemostasis, 112 (3), 558-565. [BibTeX]
• Junker, J. P. , Lönnqvist, S. , Rakar, J. , Karlsson, L. K. , Grenegård, M. & Kratz, G. (2013). Differentiation of human dermal fibroblasts towards endothelial cells.  Differentiation, 85 (3), 67-77. [BibTeX]
• Elvers, M. , Grenegård, M. , Khoshjabinzadeh, H. , Münzer, P. , Borst, O. , Tian, H. , Di Paolo, G. , Lang, F. & et al. (2012). A novel role for phospholipase D as an endogenous negative regulator of platelet sensitivity.  Cellular Signalling, 24 (9), 1743-52. [BibTeX]
• Kälvegren, H. , Skoglund, C. , Helldahl, C. , Lerm, M. , Grenegård, M. & Bengtsson, T. (2010). Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X(1)-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y(1) and P2Y(12) receptor activation.  Thrombosis and Haemostasis, 103 (2), 398-407. [BibTeX]
• Kälvegren, H. , Andersson, J. , Grenegård, M. & Bengtsson, T. (2007). Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors.  European Journal of Pharmacology, 566 (1-3), 20-27. [BibTeX]

Böcker

• Venizelos, N. , Sirsjö, A. , Grenegård, M. , Karlsson, M. , Andersson, S. , Hjelmqvist, H. , Ericsson, E. , Kihlgren, A. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Grenegård, M. (ed.) , Karlsson, M. (ed.) , Andersson, S. (ed.) , Hjelmqvist, H. (ed.) , Ericsson, E. (ed.) , Kihlgren, A. (ed.) & Söderquist, B. (ed.) (2016). Örebro University’s Nobel Day Festivities: Book of abstracts, 2016. Örebro: Örebro universitet. [BibTeX]
• Venizelos, N. , Sirsjö, A. , Grenegård, M. & Karlsson, M. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Grenegård, M. (ed.) & Karlsson, M. (ed.) (2015). Örebro University’s Nobel Day Festivities: Book of abstracts 2015. Örebro: Örebro universitet. [BibTeX]
• Venizelos, N. , Sirsjö, A. , Ljungqvist, O. , Kihlgren, A. , Grenegård, M. , Möller, C. , Danermark, B. , Eriksson, C. & et al. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ljungqvist, O. (ed.) , Kihlgren, A. (ed.) , Grenegård, M. (ed.) , Möller, C. (ed.) , Danermark, B. (ed.) , Eriksson, C. (ed.) , Ericsson, C. (ed.) & Kadi, F. (ed.) (2014). Örebro University’s Nobel Day Festivities: Book of abstracts 2014. Örebro: Örebro universitet. [BibTeX]
• Venizelos, N. , Sirsjö, A. , Ljungqvist, O. , Nilsson, U. , Grenegård, M. , Eriksson, C. & Ericsson, C. Venizelos, N. (ed.) , Sirsjö, A. (ed.) , Ljungqvist, O. (ed.) , Nilsson, U. (ed.) , Grenegård, M. (ed.) , Eriksson, C. (ed.) & Ericsson, C. (ed.) (2013). Örebro University’s Nobel Day Festivities: Book of abstracts 2013. Örebro: Örebro universitet. [BibTeX]

Konferensbidrag

• Haug, M. , Lindkvist, M. , Hedlund, P. , Lindström, E. , Bäck, A. , Thörn, E. , Pournara, D. , Fotopoulou, T. & et al. (2026). NOVEL 6-PIPERAZINYL-PURINE ANALOGUES BEARING DINITRATE ESTERS EXHIBIT BIFUNCTIONAL CARDIOPROTECTIVE EFFECTS. I:  Atherosclerosis. Konferensbidrag vid 94th Congress of the European Atherosclerosis Society (EAS 2026), Athens, Greece, May 24-27, 2026. Elsevier. [BibTeX]
• Haug, M. , Lindkvist, M. , Hedlund, P. , Lindström, E. , Bäck, A. , Thörn, E. , Pournara, D. , Fotopoulou, T. & et al. (2026). Novel 6-piperazinyl-purine analogues bearing dinitrate esters exhibit bifunctional cardioprotective effects. Konferensbidrag vid 94th Congress of the European Atherosclerosis Society (EAS 2026), Athens, Greece, May 24-27, 2026. [BibTeX]
• Haug, M. , Lindkvist, M. , Göthlin Eremo, A. , Olivecrona, H. , de Chateau, M. , Grenegård, M. & Fransén, K. (2026). Pharmacological evaluation of the novel IL-1R1 antagonist Isunakinra in suppressing endothelial inflammation. I:  WCP2026 ABSTRACT BOOK ORAL. Konferensbidrag vid World Congress of Basic and Clinical Pharmacology July 2026, Melbourne, Australia, July 12-17, 2026. [BibTeX]
• Grenegård, M. , Lindkvist, M. , Jakobsson, J. , Lynnfeldt, F. , Sandberg, B. , Lindström, E. , Hurtsén, A. S. , Haug, M. & et al. (2024). Elucidating antiplatelet activity of the novel nitric oxide-donor. Konferensbidrag vid The 13th international conference on the Biology, chemistry, and therapeutic applications of nitric oxide,Stockholm, Sweden, August 21-23, 2024. [BibTeX]
• Grenegård, M. , Koufaki, M. , Lindkvist, M. , Haug, M. , Fotopoulou, T. , Ansari, S. , Zervou, M. , Jakobsson, J. & et al. (2024). Two novel dinitrate ester bearing piperazinyl-purine analogues (MK177 and MK222) elicit nitric oxide dependent and independent effects on the cardiovascular system. Konferensbidrag vid The 13th international conference on the Biology, chemistry, and therapeutic applications of nitric oxide, Stockholm, Sweden, August 21-23, 2024. [BibTeX]
• Grenegård, M. , Koufaki, M. , Zervou, M. , Fotopoulou, T. , Lindström, E. , Nilsson, K. F. , Lindkvist, M. & Fransén, K. (2023). The cardioprotective, anti-inflammatory and antithrombotic piperazinyl-purine analogue MK177 is a bifunctional drug with promising therapeutic potential. I:  British Journal of Pharmacology. Macmillan Publishers Ltd.. [BibTeX]

Manuskript

• Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. [BibTeX]
• Befekadu, R. , Grenegård, M. , Larsson, A. , Christensen, K. , Nilsson, B. & Ramström, S. Activation of the lectin complement pathway during and after ST segment elevation myocardial infarction. [BibTeX]
• Lindkvist, M. , Zegeye, M. M. , Sirsjö, A. , Grenegård, M. & Ljungberg, L. U. Comparative evaluation of gp130 signalling cytokines in human endothelial cells : evidence for both specific and overlapping molecular responses. [BibTeX]
• Lindkvist, M. , Ljungberg, L. U. , Fälker, K. , Ramström, S. , Kardeby, C. , Sirsjö, A. & Grenegård, M. IL-6 trans-signalling inhibits micro- and macro-aggregation induced by epinephrine in human platelets. [BibTeX]
• Kardeby, C. , Sirsjö, A. , Ljungberg, L. & Grenegård, M. Sulfated glycopolymers and polysaccharides regulate inflammation-related proteins in human vascular endothelial cells. [BibTeX]