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Sofia Ramström

Tjänstetitel: Universitetslektor Organisation: Institutionen för medicinska vetenskaper

E-post:

Telefon: 019 303147

Rum: C2108

Sofia Ramström

Forskningsämne

Forskningsmiljöer

Om Sofia Ramström

My research is focused on the function and physiology of blood platelets and their interactions with the coagulation system and with other cells. A special interest is the role and function for the platelet subpopulations with different properties that forms upon platelet activation.

A main theme has been to develop new methods and technologies to study platelets, based on techniques such as flow cytometry, free oscillation rheometry and microcontact printing. These techniques are used in current projects to study platelet function in different clinical settings: 

  • Platelet function in transfusion medicine
  • Platelet function in thoracic surgery
  • Platelet function in haematological diseases

Comittments:

Co-chair in SSC Subcommittee on Platelet Physiology for the International Society on Thrombosis and Haemostasis

 

Publikationer

Artiklar i tidskrifter |  Artiklar, forskningsöversikter |  Konferensbidrag |  Manuskript | 

Artiklar i tidskrifter

Bergemalm, D. , Ramström, S. , Kardeby, C. , Hultenby, K. , Göthlin Eremo, A. , Sihlbom, C. , Bergström, J. , Palmblad, J. & et al. (2020). Platelet proteome and function in X-linked thrombocytopenia with thalassemia and in silico comparisons with gray platelet syndrome. Haematologica.
Singh, S. , Damén, T. , Nygren, A. , Shams Hakimi, C. , Ramström, S. , Dellborg, M. , Lindahl, T. L. , Hesse, C. & et al. (2019). Adrenaline Improves Platelet Reactivity in Ticagrelor-Treated Healthy Volunteers. Thrombosis and Haemostasis, 119 (5), 735-743.
Rajan, M. R. , Sotak, M. , Barrenäs, F. , Shen, T. , Borkowski, K. , Ashton, N. J. , Biörserud, C. , Lindahl, T. L. & et al. (2019). Comparative analysis of obesity-related cardiometabolic and renal biomarkers in human plasma and serum. Scientific Reports, 9 (1).
Macwan, A. S. , Boknäs, N. , Ntzouni, M. P. , Ramström, S. , Gibbins, J. M. , Faxälv, L. & Lindahl, T. L. (2019). Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors. Haematologica, 104 (7).
Boknäs, N. , Macwan, A. S. , Södergren, A. L. & Ramström, S. (2019). Platelet function testing at low platelet counts: When can you trust your analysis?. Research and Practice in Thrombosis and Haemostasis, 3 (2), 285-290.
Singh, S. , Malm, C. J. , Ramström, S. , Hesse, C. & Jeppsson, A. (2018). Adrenaline enhances in vitro platelet activation and aggregation in blood samples from ticagrelor-treated patients. Research and Practice in Thrombosis and Haemostasis, 2 (4), 718-725.
Olsson, A. , Alfredsson, J. , Ramström, S. , Svedjeholm, R. , Kenny, D. , Håkansson, E. , Berglund, J. S. & Berg, S. (2018). Better platelet function, less fibrinolysis and less hemolysis in re-transfused residual pump blood with the Ringer’s chase technique: a randomized pilot study. Perfusion, 33 (3), 185-193.
Boknäs, N. , Ramström, S. , Faxälv, L. & Lindahl, T. L. (2018). Flow cytometry-based platelet function testing is predictive of symptom burden in a cohort of bleeders. Platelets, 29 (5), 512-519.
Centellas, D. S. , Gudlur, S. , Vicente-Carrillo, A. , Ramström, S. & Lindahl, T. L. (2017). A cluster of aspartic residues in the extracellular loop II of PAR 4 is important for thrombin interaction and activation of platelets. Thrombosis Research, 154, 84-92.
Södergren, A. L. & Ramström, S. (2017). Detection of Lysosomal Exocytosis in Platelets by Flow Cytometry. Methods in Molecular Biology, 1594, 191-203.
Macwan, A. , Boknäs, N. , Ramström, S. , Berg, S. , Faxälv, L. & Lindahl, T. (2017). Gradient-dependent Modulation of Platelet Stimulatory G-protein Coupled Receptors (GPCR) Signaling. Research and Practice in Thrombosis and Haemostasis, 1 (S1), 1223-1223.
Ignatova, A. , Nikitin, E. , Tharmakulanathan, A. , Ramström, S. , Poletaev, A. , Polokhov, D. , Fedotov, A. , Seregina, E. & et al. (2017). Platelet Function and Ibrutinib Treatment in Chronic Lymphocytic Leukaemia and Mantle Cell Lymphoma: Effects of Drug and of Disease Itself. Research and Practice in Thrombosis and Haemostasis, 1 (S1), 1344-1344.
Södergren, A. & Ramström, S. (2017). Platelet reactivity and receptor density in platelets with different MPV. Research and Practice in Thrombosis and Haemostasis, 1 (S1), 1235-1236.
Lindahl, T. L. , Ramström, S. , Boknas, N. & Faxalv, L. (2016). Caveats in studies of the physiological role of polyphosphates in coagulation. Biochemical Society Transactions, 44 (1), 35-39.
Deb, S. , Sjöström, C. , Tharmakulanathan, A. , Boknäs, N. , Lotfi, K. & Ramström, S. (2016). Individual variation in hemostatic alterations caused by tyrosine kinase inhibitors: a way to improve personalized cancer therapy?. Thrombosis Research, 140 (Suppl. 1), S196-S197.
Lindahl, T. L. , Macwan, A. S. & Ramström, S. (2016). Protease-activated receptor 4 is more important than protease-activated receptor 1 for the thrombin-induced procoagulant effect on platelets. Journal of Thrombosis and Haemostasis, 14 (8), 1639-1641.
Sodergren, A. L. , Holm, A. B. S. , Ramström, S. , Lindström, E. G. , Grenegård, M. & Öllinger, K. (2016). Thrombin-induced lysosomal exocytosis in human platelets is dependent on secondary activation by ADP and regulated by endothelial-derived substances. Platelets, 27 (1), 86-92.
Connolly-Andersen, A. , Sundberg, E. , Ahlm, C. , Hultdin, J. , Baudin, M. , Larsson, J. , Dunne, E. , Kenny, D. & et al. (2015). Increased Thrombopoiesis and Platelet Activation in Hantavirus-Infected Patients. Journal of Infectious Diseases, 212 (7), 1061-1069.
Tynngård, N. , Wallstedt, M. , Södergren, A. L. , Faxälv, L. & Ramström, S. (2015). Platelet adhesion changes during storage studied with a novel method using flow cytometry and protein-coated beads. Platelets, 26 (2), 177-185.
Lindgren, M. , Meijers, J. C. M. , Biemond, B. J. , Ramström, S. , Lindahl, T. L. , Eriksson, P. , Leitgeb, A. M. , Wahlgren, M. & et al. (2015). Sevuparin: effects on hemostasis of a novel polysaccharide drug derived from heparin. Journal of Thrombosis and Haemostasis, 13 (S2), 369-369.
Boknäs, N. , Faxälv, L. , Ström, J. O. , Tengvall, P. , Theodorsson, E. , Ramström, S. & Lindahl, T. L. (2014). Platelets do not generate activated factor XII: how inappropriate experimental models have led to misleading conclusions. Blood, 124 (10), 1692-1694.
Peng, X. , Ramström, S. , Kurz, T. , Grenegård, M. & Segelmark, M. (2014). The neutrophil serine protease PR3 induces shape change of platelets via the Rho/Rho kinase and Ca2+ signaling pathways. Thrombosis Research, 134 (2), 418-425.
Boknäs, N. , Faxälv, L. , Sanchez Cenellas, D. , Wallstedt, M. , Ramström, S. , Grenegård, M. & Lindahl, T. L. (2014). Thrombin-induced platelet activation via PAR4: pivotal role for exosite II. Thrombosis and Haemostasis, 112 (3), 558-565.
Lopez, A. , Kenny, D. , Basabe-Desmonts, L. , Ramström, S. , Jose, B. & Somers, M. (2013). A novel platelet assay that measures the effect of clopidogrel in vivo. Journal of Thrombosis and Haemostasis, 11 (S2), 73-73.
Lopez-Alonso, A. , Jose, B. , Somers, M. , Egan, K. , Foley, D. P. , Ricco, A. J. , Ramström, S. , Basabe-Desmonts, L. & et al. (2013). Individual Platelet Adhesion Assay: Measuring Platelet Function and Antiplatelet Therapies in Whole Blood via Digital Quantification of Cell Adhesion. Analytical Chemistry, 85 (13), 6497-6504.
Faxälv, L. , Boknäs, N. , Ström, J. O. , Tengvall, P. , Theodorsson, E. , Ramström, S. & Lindahl, T. L. (2013). Putting polyphosphates to the test: evidence against platelet-induced activation of factor XII. Blood, 122 (23), 3818-3824.
Södergren, A. L. , Ollinger, K. & Ramström, S. (2013). Subdivision according to size is necessary for correct interpretation of data regarding platelet expression of active GPIIb/IIIa and phosphatidylserine. Journal of Thrombosis and Haemostasis, 11 (S1), 498-498.
Boknäs, N. , Faxälv, L. , Ramström, S. & Lindahl, T. (2013). Thrombin generation in plasma measured with a commercial reagent for the detection of microparticle-derived tissue factor is heavily influenced by contact activation. Journal of Thrombosis and Haemostasis, 11 (S1), 401-402.
Tynngård, N. , Ramström, S. & Berlin, G. (2012). Adhesion Capacity of Platelets During Storage: Evaluation of a Flow Cytometric Adhesion Assay. Transfusion, 52 (S3), 70A-70A.
Nylander, M. , Osman, A. , Ramström, S. , Aklint, E. , Larsson, A. & Lindahl, T. L. (2012). The role of thrombin receptors PAR1 and PAR4 for PAI-1 storage, synthesis and secretion by human platelets. Thrombosis Research, 129 (4), E51-E58.
Börgeson, E. , Lönn, J. , Bergström, I. , Brodin, V. P. , Ramström, S. , Nayeri, F. , Särndahl, E. & Bengtsson, T. (2011). Lipoxin A(4) inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. Infection and Immunity, 79 (4), 1489-1497.
Ramström, S. , O'Neill, S. , Dunne, E. & Kenny, D. (2010). Annexin V binding to platelets is agonist, time and temperature dependent. Platelets, 21 (4), 289-296.
Basabe-Desmonts, L. , Ramström, S. , Meade, G. , O'Neill, S. , Riaz, A. , Lee, L. P. , Ricco, A. J. & Kenny, D. (2010). Single-Step Separation of Platelets from Whole Blood Coupled with Digital Quantification by Interfacial Platelet Cytometry (iPC). Langmuir, 26 (18), 14700-14706.

Artiklar, forskningsöversikter

Ramström, S. , Södergren, A. L. , Tynngård, N. & Lindahl, T. L. (2016). Platelet Function Determined by Flow Cytometry: New Perspectives?. Seminars in Thrombosis and Hemostasis, 42 (3), 268-281.
Tynngård, N. , Lindahl, T. L. & Ramström, S. (2015). Assays of different aspects of haemostasis: what do they measure?. Thrombosis Journal, 13.

Konferensbidrag

Södergren, A. & Ramström, S. (2016). Platelet subpopulations : do they exist? . Konferensbidrag vid 3rd EUPLAN Conference, Bad Homburg, Germany, 21-23 September, 2016.
Sánchez Centellas, D. , Vicente-Carrillo, A. , Ramström, S. & Lindahl, T. (2014). Advances on yeast methods to study recombinant human PAR4. Konferensbidrag vid 2nd EUPLAN (European Platelet Network) Conference, Strasbourg, France, September 24-26.
Deb, S. & Ramström, S. (2014). Intracellular signaling in platelet sub-populations: a flow cytometry-based approach. Konferensbidrag vid 47th Nordic Coagulation Meeting, Visby, Sweden, September 9-12, 2014.
Andraos, R. , Södergren, A. , Öllinger, K. & Ramström, S. (2014). Reactive oxygen species enhance generation of subpopulations of procoagulant platelets. Konferensbidrag vid 2nd EUPLAN (European Platelet Network) Conference, Le Bischenberg, France, September 24-26, 2014.
Andraos, R. , Södergren, A. , Öllinger, K. & Ramström, S. (2014). Reactive oxygen species enhance generation of subpopulations of procoagulant platelets. Konferensbidrag vid 47th Nordic Coagulation Meeting, Visby, Sweden, September 9-12, 2014.
Batakis, P. , Lopez-Alonso, A. , Claesson, K. , Kenny, D. , Basabe-Desmonts, L. & Ramström, S. (2013). Microcontact printing as a tool to study platelet adhesion. Konferensbidrag vid 46th Nordic Coagulation Meeting, Tromsö, Norway, June 6-8, 2013.
Boknäs, N. , Faxälv, L. & Ramström, S. (2013). Phospholipid-containing reagents for the detection of tissue factor on microparticles by thrombin generation cause analytical errors by amplifying the contact activation pathway. Konferensbidrag vid Eurothrombosis Summit, Uppsala, Sweden, October 3-5, 2013.
Lopez-Alonso, A. , Basabe-Desmonts, L. , Ramström, S. , Jose, B. , Sommers, M. , Redahan, L. , Conlon, P. & Kenny, D. (2012). A novel platelet function assay that identifies bleeding risk and quantifies anti-platelet drug effect. Konferensbidrag vid BSHT/13th UK Platelet Group meeting, Bath, UK, October 18-19, 2012.
Södergren, A. , Tynngård, N. & Ramström, S. (2012). Changes in platelet function during storage : evaluation of a flow cytometry method for studies of platelet adhesion and activation. Konferensbidrag vid BSHT/13th UK Platelet Group meeting, Bath, UK, October 18-19, 2012.
Södergren, A. , Tynngård, N. & Ramström, S. (2012). Changes in platelet function during storage: evaluation of a flow cytometry method for studies of platelet adhesion and activation. Konferensbidrag vid EUPLAN (European Platelet Network) Conference, Maastricht, the Netherlands, September 19-21, 2012.
Faxälv, L. , Ramström, S. , Soutukorva, K. , Tengvall, P. & Lindahl, T. (2012). Coagulation factor XII is not activated by platelets but facilitates platelet-driven propagation of coagulation . Konferensbidrag vid EUPLAN (European Platelet Network) Conference, Maastricht, the Netherlands, September 19-21, 2012.
Faxälv, L. , Wallstedt, M. & Ramström, S. (2011). A flow cytometric method to study platelet adhesion to protein-coated polystyrene beads. Konferensbidrag vid 13th UK Platelet Group Meeting, Cardiff, September 8 – 9th, 2011.
Basabe-Desmonts, L. , Ramström, S. , Lopez-Alonso, A. , Somers, M. , Ricco, A. J. & Kenny, D. (2010). Disposable bioanalytical microdevice for monitoring the effect of anti-platelet drugs. I: 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010. Konferensbidrag vid 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, Groningen, The Netherlands, 3 - 7 October, 2010 (ss. 1388-1390).

Manuskript

Lindkvist, M. , Ljungberg, L. U. , Fälker, K. , Ramström, S. , Kardeby, C. , Sirsjö, A. & Grenegård, M. IL-6 trans-signalling inhibits micro- and macro-aggregation induced by epinephrine in human platelets.