Torbjörn Bengtsson
Tjänstetitel: Professor Organisation: Institutionen för medicinska vetenskaper
E-post:
Telefon: 019 302159
Rum: C2206
Om Torbjörn Bengtsson
Denna information finns endast på engelska.
Forskningsprojekt
Forskningsprojekt
- Leukocytes in periodontitis
- Bacteriocins in prevention and treatment of infections
- Gingival fibroblasts as immune cells in periodontitis
- Lactobacilli and bacteriocins in prevention and treatment of periodontitis, peri-implantitis and systemic inflammation
- Lipoprotein profile in periodontitis and its role in cardiovascular disease
- Mekanismer vid nedsatt sårläkning: effekter av proteolytiska bakterier på trombocyt-inducerad celltillväxt
- Parodontit och hjärt-kärlsjukdom: betydelsen av Porphyromonas gingivalis infektion och dess effekter på LDL, HGF och cell aktivering
- Plastic antibodies and nanoplasmonic sensors in targeting risk markers of periodontitis and cardiovascular disease
- Studier av inflammatoriska processer och utveckling av nya metoder för diagnos och behandling av kroniska inflammatoriska sjukdomar med hjälp av nanosensorteknologi
- T-cells in periodontitis
- The effects of periodontal pathogens on gene and protein expression in vascular smooth muscle cells
- The role of platelets in sensing bacterial infection and causing inflammation
- Toll-like receptor 2 orsakad trombocyt aktivering och koppling till hjärt-kärlsjukdom och aspirinokänslighet
Forskargrupper
Forskargrupper
Publikationer
Publikationer
Artiklar i tidskrifter |
Kapitel i böcker, del av antologier |
Manuskript |
Artiklar i tidskrifter
Bengtsson, T. , Selegård, R. , Musa, A. , Hultenby, K. , Utterström, J. , Sivlér, P. , Skog, M. , Nayeri, F.
& et al.
(2020). Plantaricin NC8 αβ exerts potent antimicrobial activity against Staphylococcus spp. and enhances the effects of antibiotics. Scientific Reports, 10 (1).
Ljunggren, S. , Bengtsson, T. , Karlsson, H. , Johansson Starkhammar, C. , Palm, E. , Nayeri, F. , Ghafouri, B. , Davies, J.
& et al.
(2019). Modified lipoproteins in periodontitis: a link to cardiovascular disease?. Bioscience Reports, 39 (3).
Selegård, R. , Musa, A. , Nyström, P. , Aili, D. , Bengtsson, T.
& Khalaf, H. (2019). Plantaricins markedly enhance the effects of traditional antibiotics against Staphylococcus epidermidis. Future microbiology, 14 (3), 195-206.
Fürsatz, M. , Skog, M. , Sivlér, P. , Palm, E. , Aronsson, C. , Skallberg, A. , Greczynski, G. , Khalaf, H.
& et al.
(2018). Functionalization of bacterial cellulose wound dressings with the antimicrobial peptide ε-poly-L-Lysine. Biomedical Materials, 13.
Lönn, J. , Ljunggren, S. , Klarström-Engström, K. , Demirel, I. , Bengtsson, T.
& Karlsson, H. (2018). Lipoprotein modifications by gingipains of Porphyromonas gingivalis. Journal of Periodontal Research, 53 (3), 403-413.
Jayaprakash, K. , Demirel, I. , Khalaf, H.
& Bengtsson, T. (2018). Porphyromonas gingivalis-induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain-dependent manner. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 126 (8), 667-677.
Bengtsson, T. , Lönn, J. , Khalaf, H.
& Palm, E. (2018). The lantibiotic gallidermin acts bactericidal against Staphylococcus epidermidis and Staphylococcus aureus and antagonizes the bacteria-induced proinflammatory responses in dermal fibroblasts. MicrobiologyOpen, 7 (6).
Bengtsson, T. , Zhang, B. , Selegård, R. , Wiman, E. , Aili, D.
& Khalaf, H. (2017). Dual action of bacteriocin PLNC8 alpha beta through inhibition of Porphyromonas gingivalis infection and promotion of cell proliferation. Pathogens and Disease, 75 (5).
Jayaprakash, K. , Demirel, I. , Gunaltay, S. , Khalaf, H.
& Bengtsson, T. (2017). PKC, ERK/p38 MAP kinases and NF-B targeted signalling play a role in the expression and release of IL-1β and CXCL8 in Porphyromonas gingivalis-infected THP1 cells. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (7), 623-633.
Palm, E. , Demirel, I. , Bengtsson, T.
& Khalaf, H. (2017). The role of toll-like and protease-activated receptors and associated intracellular signaling in Porphyromonas gingivalis-infected gingival fibroblasts. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 125 (2), 157-169.
Khalaf, H. , Nakka, S. S. , Sandén, C. , Svärd, A. , Hultenby, K. , Scherbak, N. , Aili, D.
& Bengtsson, T. (2016). Antibacterial effects of Lactobacillus and bacteriocin PLNC8 αβ on the periodontal pathogen Porphyromonas gingivalis. BMC Microbiology, 16 (1).
Wickham, A. , Vagin, M. , Khalaf, H. , Bertazzo, S. , Hodder, P. , Dånmark, S. , Bengtsson, T. , Altimiras, J.
& et al.
(2016). Electroactive biomimetic collagen-silver nanowire composite scaffolds. Nanoscale, 8 (29), 14146-14155.
Wu, C. , Nakka, S. , Mansouri, S. , Bengtsson, T. , Nayeri, T.
& Nayeri, F. (2016). In vitro model of production of antibodies; a new approach to reveal the presence of key bacteria in polymicrobial environments. BMC Microbiology, 16 (1).
Zhang, B. , Sirsjö, A. , Khalaf, H.
& Bengtsson, T. (2016). Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis. Scientific Reports, 6.
Nakka, S. S. , Lönn, J. , Starkhammar Johansson, C. , Bengtsson, T.
& Nayeri, F. (2015). Antibodies produced in vitro in the detection of periodontal bacteria by using surface plasmon resonance analysis. Clinical and Experimental Dental Research, 1 (1), 32-44.
Zhang, B. , Khalaf, H. , Sirsjö, A.
& Bengtsson, T. (2015). Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells. Infection and Immunity, 83 (11), 4256-4265.
Bengtsson, T. , Khalaf, A.
& Khalaf, H. (2015). Secreted gingipains from Porphyromonas gingivalis colonies exert potent immunomodulatory effects on human gingival fibroblasts. Microbiology Research, 178, 18-26.
Palm, E. , Khalaf, H.
& Bengtsson, T. (2015). Suppression of inflammatory responses of human gingival fibroblasts by gingipains from Porphyromonas gingivalis. Molecular Oral Microbiology, 30 (1), 74-85.
Jayaprakash, K. , Demirel, I. , Khalaf, H.
& Bengtsson, T. (2015). The role of phagocytosis, oxidative burst and neutrophil extracellular traps in the interaction between neutrophils and the periodontal pathogen Porphyromonas gingivalis. Molecular Oral Microbiology, 30 (5), 361-375.
Klarström-Engström, K. , Khalaf, H. , Kälvegren, H.
& Bengtsson, T. (2015). The role of Porphyromonas gingivalis gingipains in platelet activation and innate immune modulation. Molecular Oral Microbiology, 30 (1), 62-73.
Palm, E. , Demirel, I. , Bengtsson, T.
& Khalaf, H. (2015). The role of toll-like and protease-activated receptors in the expression of cytokines by gingival fibroblasts stimulated with the periodontal pathogen Porphyromonas gingivalis. Cytokine, 76 (2), 424-432.
Khalaf, H. , Lönn, J.
& Bengtsson, T. (2014). Cytokines and chemokines are differentially expressed in patients with periodontitis: Possible role for TGF-beta 1 as a marker for disease progression. Cytokine, 67 (1), 29-35.
Jayaprakash, K. , Khalaf, H.
& Bengtsson, T. (2014). Gingipains from Porphyromonas gingivalis play a significant role in induction and regulation of CXCL8 in THP-1 cells. BMC Microbiology, 14.
Lönn, J. , Johansson, C. S. , Nakka, S. , Palm, E. , Bengtsson, T. , Nayeri, F.
& Ravald, N. (2014). High Concentration but Low Activity of Hepatocyte Growth Factor in Periodontitis. Journal of Periodontology, 85 (1), 113-122.
Fälker, K. , Klarström-Engström, K. , Bengtsson, T. , Lindahl, T. L.
& Grenegård, M. (2014). The Toll-like receptor 2/1 (TLR2/1) complex initiates human platelet activation via the src/Syk/LAT/PLC gamma 2 signalling cascade. Cellular Signalling, 26 (2), 279-286.
Klarström-Engström, K. , Brommesson, C. , Kälvegren, H.
& Bengtsson, T. (2014). Toll like receptor 2/1 mediated platelet adhesion and activation on bacterial mimetic surfaces is dependent on src/Syk-signaling and purinergic receptor P2X1 and P2Y12 activation. Biointerphases, 9 (4), 041003.
Palm, E. , Khalaf, H.
& Bengtsson, T. (2013). Porphyromonas gingivalis downregulates the immune response of fibroblasts. BMC Microbiology, 13, 155.
Paramel, G. , Fransén, K. , Hurtig-Wennlöf, A. , Bengtsson, T. , Jansson, J.
& Sirsjö, A. (2013). Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals. Biomedical Reports, 1 (6), 879-882.
Khalaf, H. , Demirel, I.
& Bengtsson, T. (2013). Suppression of inflammatory gene expression in T cells by Porphyromonas gingivalis is mediated by targeting MAPK signaling. Cellular & Molecular Immunology, 10 (5), 413-422.
Zhang, B. , Elmabsout, A. A. , Khalaf, H. , Basic, V. T. , Jayaprakash, K. , Kruse, R. , Bengtsson, T.
& Sirsjö, A. (2013). The periodontal pathogen Porphyromonas gingivalis changes the gene expression in vascular smooth muscle cells involving the TGFbeta/Notch signalling pathway and increased cell proliferation. BMC Genomics, 14, 770.
Khalaf, H.
& Bengtsson, T. (2012). Altered T-cell responses by the periodontal pathogen Porphyromonas gingivalis. PLoS ONE, 7 (9).
Skoglund, C. , Wettero, J.
& Bengtsson, T. (2012). C1q regulates collagen-dependent production of reactive oxygen species, aggregation and levels of soluble P-selectin in whole blood. Immunology Letters, 142 (1-2), 28-33.
Abrikossova, N. , Skoglund, C. , Ahrén, M. , Bengtsson, T.
& Uvdal, K. (2012). Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes. Nanotechnology, 23 (27).
Lönn, J. , Starkhammar Johansson, C. , Kälvegren, H. , Brudin, L. , Skoglund, C. , Garvin, P. , Särndahl, E. , Ravald, N.
& et al.
(2012). Hepatocyte growth factor in patients with coronary artery disease and its relation to periodontal condition. Results in Immunology, 2, 7-12.
Lönn, J. , Shahzad, F. , Uhlin, F. , Bengtsson, T. , Almroth, G.
& Nayeri, F. (2012). High concentration but low biological activity of hepatocyte growth factor in patients with chronic renal failure. Advances in Bioscience and Biotechnology, 3 (4), 516-523.
Svensson Holm, A. B. , Bengtsson, T. , Grenegård, M.
& Lindström, E. G. (2012). Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation. Experimental Cell Research, 318 (5), 632-640.
Lönn, J. , Hallström, J.
& Bengtsson, T. (2012). P. gingivalis-induced aggregation and ros production in whole blood is dependent on gingipains. Cardiovascular Research, 93, S35-S35.
Nixon Tangi, T. , Elmabsout, A. A. , Bengtsson, T. , Sirsjö, A.
& Fransén, K. (2012). Role of NLRP3 and CARD8 in the regulation of TNF-α induced IL-1β release in vascular smooth muscle cells. International Journal of Molecular Medicine, 30 (3), 697-702.
Klarström-Engström, K. , Skoglund, C. , Kälvegren, H.
& Bengtsson, T. (2012). The role of platelets in inflammation at sites of infection: toll like receptor 2/1 mediated platelet adhesion on bacterial peptide-mimetic surfaces. Cardiovascular Research, 93, S8-S8.
Börgeson, E. , Lönn, J. , Bergström, I. , Brodin, V. P. , Ramström, S. , Nayeri, F. , Särndahl, E.
& Bengtsson, T. (2011). Lipoxin A(4) inhibits porphyromonas gingivalis-induced aggregation and reactive oxygen species production by modulating neutrophil-platelet interaction and CD11b expression. Infection and Immunity, 79 (4), 1489-1497.
Svensson Holm, A. B. , Bengtsson, T. , Grenegard, M.
& Lindström, E. G. (2011). Platelet membranes induce airway smooth muscle cell proliferation. Platelets, 22 (1), 45-55.
Skoglund, C. , Wetterö, J. , Tengvall, P.
& Bengtsson, T. (2010). C1q induces a rapid up-regulation of P-selectin and modulates collagen- and collagen-related peptide-triggered activation in human platelets. Immunobiology, 215 (12), 987-995.
Ahren, M. , Selegard, L. , Klasson, A. , Soderlind, F. , Abrikossova, N. , Skoglund, C. , Bengtsson, T. , Engstrom, M.
& et al.
(2010). Synthesis and Characterization of PEGylated Gd2O3 Nanoparticles for MRI Contrast Enhancement. Langmuir, 26 (8), 5753-5762.
Kälvegren, H. , Fridfeldt, J.
& Bengtsson, T. (2010). The role of plasma adenosine deaminase in chemoattractant-stimulated oxygen radical production in neutrophils. European Journal of Cell Biology, 89 (6), 462-467.
Kälvegren, H. , Skoglund, C. , Helldahl, C. , Lerm, M. , Grenegård, M.
& Bengtsson, T. (2010). Toll-like receptor 2 stimulation of platelets is mediated by purinergic P2X(1)-dependent Ca2+ mobilisation, cyclooxygenase and purinergic P2Y(1) and P2Y(12) receptor activation. Thrombosis and Haemostasis, 103 (2), 398-407.
Kälvegren, H. , Fridfeldt, J. , Garvin, P. , Wind, L. , Leanderson, P. , Kristenson, M. , Kihlström, E. , Bengtsson, T.
& et al.
(2008). Correlation between rises in Chlamydia pneumoniae-specific antibodies, platelet activation and lipid peroxidation after percutaneous coronary intervention. European Journal of Clinical Microbiology and Infectious Diseases, 27 (7), 503-511.
Skoglund, C. , Wetterö, J. , Skogh, T. , Sjöwall, C. , Tengvall, P.
& Bengtsson, T. (2008). C-reactive protein and C1q regulate platelet adhesion and activation on adsorbed immunoglobulin G and albumin. Immunology and Cell Biology, 86 (5), 466-474.
Svensson Holm, A. , Bengtsson, T. , Grenegård, M.
& Lindström, E. G. (2008). Platelets stimulate airway smooth muscle cell proliferation through mechanisms involving 5-lipoxygenase and reactive oxygen species. Platelets, 19 (7), 528-536.
Bengtsson, T. , Karlsson, H. , Gunnarsson, P. , Skoglund, C. , Elison, C. , Leanderson, P.
& Lindahl, M. (2008). The periodontal pathogen Porphyromonas gingivalis cleaves apoB-100 and increases the expression of apoM in LDL in whole blood leading to cell proliferation. Journal of Internal Medicine, 263 (5), 558-571.
Nylander, M. , Lindahl, T. L. , Bengtsson, T.
& Grenegård, M. (2008). The periodontal pathogen Porphyromonas gingivalis sensitises human blood platelets to epinephrine. Platelets, 19 (5), 352-358.
Kälvegren, H. , Andersson, J. , Grenegård, M.
& Bengtsson, T. (2007). Platelet activation triggered by Chlamydia pneumoniae is antagonized by 12-lipoxygenase inhibitors but not cyclooxygenase inhibitors. European Journal of Pharmacology, 566 (1-3), 20-27.
Sjöwall, C. , Wetterö, J. , Bengtsson, T. , Askendal, A. , Almroth, G. , Skogh, T.
& Tengvall, P. (2007). Solid-phase classical complement activation by C-reactive protein (CRP) is inhibited by fluid-phase CRP-C1q interaction. Biochemical and Biophysical Research Communications - BBRC, 352 (1), 251-258.
Kapitel i böcker, del av antologier
Khalaf, H. , Palm, E.
& Bengtsson, T. (2017). Cellular Response Mechanisms in Porphyromonas gingivalis Infection.
I:
Pachiappan Arjunan, Periodontitis: A Useful Reference (ss. 45-68).
. InTech.
Manuskript
Khalaf, H. , Nakka, S. S. , Sandén, C. , Svärd, A. , Hultenby, K. , Scherbak, N. , Aili, D.
& Bengtsson, T. Antibacterial effects of lactobacillus and bacteriocin NC8 αβ on the periodontal pathogen Porphyromonas gingivalis.
Nakka, S. S. , Palm, E. , Bengtsson, T.
& Khalaf, H. Bacteriocin plantaricin NC8 αβ antagonizes Porphyromonas gingivalis infection and induces proliferation of gingival epithelial cells.
Nakka, S. S. , Palm, E. , Nayeri, F. , Bengtsson, T.
& Khalaf, H. Effects of plantaricin NC8 αβ and antibodies on gingival epithelial cells infected by Porphyromonas gingivalis.
Jayaprakash, K. , Demirel, I. , Gunaltay, S. , Khalaf, H.
& Bengtsson, T. PKC, ERK/p38 MAP kinases and NF-κB targeted signalling plays a crucial role in expression and release of IL-1β and CXCL8 in Porphyromonas gingivalis infected monocytes.
Jayaprakash, K. , Demirel, I. , Khalaf, H.
& Bengtsson, T. Porphyromonas gingivalis induced release of reactive oxygen species and interleukin-1 beta and the effects of low density lipoproteins in monocytes and whole blood.
Klarström-Engström, K. , Magnusson, A. , Demirel, I. , Lönn, J. , Starkhammar Johansson, C. , Kälvegren, H.
& Bengtsson, T. Porphyromonas gingivalis-induced lipid peroxidation : the role of platelets, gingipains and periodontal status..
Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T.
& Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?.
Klarström-Engström, K. , Bengtsson, T.
& Khalaf, H. The platelet response to various strains of Porphyromonas gingivalis.
Palm, E. , Demirel, I. , Bengtsson, T.
& Khalaf, H. The role of toll-like and protease-activated receptors and associated intracellular signalling in Porphyromonas gingivalis-infected gingival fibroblasts.
Palm, E. , Demirel, I. , Bengtsson, T.
& Khalaf, H. The role of toll-like and protease-activated receptors in the expression of cytokines by gingival fibroblasts stimulated with the periodontal pathogen Porphyromonas gingivalis.
Zhang, B. , Sirsjö, A. , Khalaf, H.
& Bengtsson, T. Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis.