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Geena Paramel

Tjänstetitel: Forskare Organisation: Institutionen för medicinska vetenskaper


Telefon: 019 303801

Rum: C3211

Geena Paramel



Om Geena Paramel

Ischaemic heart disease is the leading cause of death and is responsible for 12.2% of all deaths worldwide, with a frequency of 17 million deaths from cardiovascular diseases every year that is caused by the combinatory effects of environmental and genetic risk factors. Atherosclerosis is the most common underlying cause of cardiovascular disease. The recent advancement in the basic science has explored inflammation as a key component involved in the pathophysiology of atherosclerosis.

My research study focusses on the role of inflammasome in aggravating the inflammation in human atherosclerosis, since inflammasome has been implicated in atherosclerosis both because of its activation by cholesterol crystals and since its activation generates the pro-inflammatory cytokine, IL-1β. The study also include theassociation of genetic variant in the gene encoding for inflammasome components to the risk of myocardial infarction.


Artiklar i tidskrifter |  Artiklar, forskningsöversikter |  Doktorsavhandlingar, sammanläggningar |  Manuskript | 

Artiklar i tidskrifter

Paramel Varghese, G. , Karadimou, G. , Göthlin Eremo, A. , Ljungberg, L. , Hedin, U. , Olofsson, P. S. , Folkersen, L. , Paulsson Berne, G. & et al. (2020). Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. Scientific Reports, 10 (1).
Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. (2019). A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition. European Journal of Pharmacology, 857.
Zegeye, M. M. , Lindkvist, M. , Fälker, K. , Kumawat, A. K. , Paramel Varghese, G. , Grenegård, M. , Sirsjö, A. & Ljungberg, L. U. (2018). Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells. Cell Communication and Signaling, 16 (1).
Biswas, D. , Cowie, A. , Tozer, K. , Perez, L. J. , Trivedi, P. , Bartlett, J. J. , Duffley, L. , Dao, K. T. & et al. (2018). Adverse Cardiometabolic Outcomes in Obese Patients Correlates Strongly with Defective Branched-Chain Amino Acid Catabolism. Journal of Molecular and Cellular Cardiology, 124, 121-122.
D'Souza, K. , Nzirorera, C. , Cowie, A. , Paramel Varghese, G. , Trivedi, P. , Eichmann, T. , Biswas, D. , Touaibia, M. & et al. (2018). Autotaxin-Lysophosphatidic Acid Signaling Contributed to Obesity-Induced Insulin Resistance in Muscle and Impairs Mitochondrial Metabolism. Journal of Lipid Research, 59 (10), 1805-1817.
Paramel Varghese, G. , Folkersen, L. , Strawbridge, R. J. , Halvorsen, B. , Yndestad, A. , Ranheim, T. , Krohg-Sørensen, K. , Skjelland, M. & et al. (2016). NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 5 (5).
Paramel, G. , Uporova, L. , Halfvarson, J. , Sirsjö, A. & Fransén, K. (2015). Polymorphism in the NLRP3 inflammasome-associated EIF2AK2 gene and inflammatory bowel disease. Molecular Medicine Reports, 11 (6), 4579-4584.
Paramel, G. , Folkersen, L. , Strawbridge, R. J. , Elmabsout, A. , Särndahl, E. , Lundman, P. , Jansson, J. , Hansson, G. K. & et al. (2013). CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. Clinical Science, 125 (8), 401-407.
Paramel, G. , Fransén, K. , Hurtig-Wennlöf, A. , Bengtsson, T. , Jansson, J. & Sirsjö, A. (2013). Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals. Biomedical Reports, 1 (6), 879-882.

Artiklar, forskningsöversikter

Paramel Varghese, G. , D’Souza, K. & Kienesberger, P. (2018). Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance. Nutrients, 10 (4).

Doktorsavhandlingar, sammanläggningar

Paramel Varghese, G. (2017). Innate immunity in human atherosclerosis and myocardial infarction: Role of CARD8 and NLRP3. (Doctoral dissertation). (Sammanläggning) Örebro: Örebro University.


Kardeby, C. , Paramel Varghese, G. , Pournara, D. , Fotopoulou, T. , Sirsjö, A. , Koufaki, M. , Fransén, K. & Grenegård, M. A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition.
Paramel Varghese, G. , Göthlin Eremo, A. , Ljungberg, L. , Sirsjö, A. & Fransén, K. CARD8, a protein of innate immunity regulates the release of inflammatory cytokines in human endothelial cells.
Paramel Varghese, G. , Zhang, B. , Khalaf, H. , Ljungberg, L. U. , Sirsjö, A. , Bengtsson, T. & Fransén, K. Poryphyromonas gingivalis induces IL-1β in aortic smooth muscle cells : possible role of gingipains?.