Matej Oresic
Tjänstetitel: Professor Organisation: Institutionen för medicinska vetenskaper
E-post:
Telefon: 019 302137
Rum: C2201
Om Matej Oresic
Matej Orešič har en doktorsexamen i biofysik från Cornell University. Han är en Professor i medicinsk vetenskap med inriktning systemmedicin vid Örebro Universitet, samt gruppledare inom systems medicin vid Åbo Centrum för Bioteknik, Åbo Universitet och en huvudforskare vid Finlands Akademis Centrum för Excellens inom Molekylär System Immunologi och Fysiologiforskning.
Matejs forskning är framför allt inriktad mot metabolomik inom biomedicin och integrativ bioinformatik. Fokus ligger på identifieringen av sjukdomssårbarheter associerade med olika metaboliska fenotyper och de underliggande mekanismerna som kopplar samman dessa sårbarheter med utvecklingen av specifika störningar, med särskild inriktning på fetma och diabetes och deras co-morbiditeter.
Dr. Orešič har också initierat det populära MZmine open source-projektet, vilket har lett till en populär mjukvara för databehandling av metabolomics. Tidigare, Dr. Orešič var huvudforskare vid Steno Diabetes Center (Gentofte, Danmark), forskarprofessor vid VTT Tekniska Forskningscentralen i Finland (Esbo, Finland), chef för beräkningsbiologi och modellering vid Beyond Genomics, Inc. (Waltham / MA) Och bioinformatiker vid LION Bioscience Research i Cambridge / MA. År 2016 fick Dr. Oresic livstidens honorärmedlemspris från Metabolomics Society. Han är medgrundare och för närvarande styrelseordförande för Nordic Metabolomics Society.
Dr Oresic har nyligen varit ordförande för två internationella metabolomikmöten:
- 1st Nordic Metabolomics Conference (Örebro, Sweden, August 26-28, 2018)
- Gordon Research Conference - Metabolomics and Human Health (Ventura, CA, USA, February 3-8, 2019)
Forskningsprojekt
- Blodbaserad metabolomik för att förutsäga svårighetsgrad och patient prognos vid traumatisk hjärnskada (meTBI)
- EPoS - Elucidating Pathways of Steatohepatitis
- Human exposure to per- and polyfluoroalkyl substances? Role of the gut microbiome and bile acid metabolism in mediating impact (PFASgut)
- Hälsoeffekter av miljöexponering tidigt i livet
- Lipid pathways en route to islet autoimmunity and type 1 diabetes
- LipidNET- Pan-European Network in Lipidomics and Epilipidomics?
- LITMUS
- Metabolomic and Proteomic markers staging progression to type 1 diabetes in autoantibody positive children
- Mother-infant interactions in relation to potential biomarkers of beta-cell autoimmunity and type 1 diabetes
- Novel analytical and computational tools for the assessment of exposure to environmental chemicals
- Rituximab för schizofrenispektrumsjukdomar. En pilotstudie.
- Rituximab för Tvångssyndrom. En pilotstudie.
- Role of environmental exposure in the initiation and progression of non-alcoholic fatty liver disease and insulin resistance
- Sen debut av inflammatorisk tarmsjukdom
Forskargrupper
Publikationer
Artiklar i tidskrifter |
Artiklar, forskningsöversikter |
Kapitel i böcker, del av antologier |
Artiklar i tidskrifter
Sen, P. , Hyötyläinen, T.
& Oresic, M. (2021). 1-Deoxyceramides: key players in lipotoxicity and progression to type 2 diabetes?. Acta Physiologica, 232 (1).
Karpale, M. , Käräjämäki, A. J. , Kummu, O. , Gylling, H. , Hyötyläinen, T. , Oresic, M. , Tolonen, A. , Hautajärvi, H.
& et al.
(2021). Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2-mediated mechanism. British Journal of Pharmacology, 178 (12), 2461-2481.
Rodriguez-Cuenca, S. , Lelliot, C. J. , Campbell, M. , Peddinti, G. , Martinez-Uña, M. , Ingvorsen, C. , Dias, A. R. , Relat, J.
& et al.
(2021). Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects. The FASEB Journal, 35 (9).
Lamichhane, S. , Dickens, A. M. , Sen, P. , Laurikainen, H. , Borgan, F. , Suvisaari, J. , Hyötyläinen, T. , Howes, O.
& et al.
(2021). Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis. Schizophrenia Bulletin, 47 (1), 160-169.
Huie, J. R. , Mondello, S. , Lindsell, C. J. , Antiga, L. , Yuh, E. L. , Zanier, E. R. , Masson, S. , Rosario, B. L.
& et al.
(2021). Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations. Journal of Neurotrauma, 38 (18), 2514-2529.
Petersen, A. Ø. , Julienne, H. , Hyötyläinen, T. , Sen, P. , Fan, Y. , Pedersen, H. K. , Jäntti, S. , Hansen, T. H.
& et al.
(2021). Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species. Scientific Reports, 11 (1).
Sen, P. , Lamichhane, S. , Mathema, V. B. , McGlinchey, A. J. , Dickens, A. M. , Khoomrung, S.
& Oresic, M. (2021). Deep learning meets metabolomics: a methodological perspective. Briefings in Bioinformatics, 22 (2), 1531-1542.
Selvaraj, E. A. , Mózes, F. E. , Ajmer Jayaswal, A. N. , Zafarmand, M. H. , Vali, Y. , Lee, J. A. , Levick, C. K. , Joseph Young, L. A.
& et al.
(2021). Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis. Journal of Hepatology.
Mózes, F. E. , Pavlides, M.
& Oresic, M. (2021). Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis. Gut.
Mikolić, A. , van Klaveren, D. , Oude Groeniger, J. , Wiegers, E. J. A. , Lingsma, H. F. , Zeldovich, M. , von Steinbüchel, N. , Roeters van Lennep, J. E.
& et al.
(2021). Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury. Journal of Neurotrauma, 38 (2), 235-251.
Dickens, A. M. , Sen, P. , Kempton, M. J. , Barrantes-Vidal, N. , Iyegbe, C. , Nordentoft, M. , Pollak, T. , Riecher-Rössler, A.
& et al.
(2021). Dysregulated Lipid Metabolism Precedes Onset of Psychosis. Biological Psychiatry, 89 (3), 288-297.
Sen, P. , Qadri, S. , Luukkonen, P. K. , Ragnarsdottir, O. , McGlinchey, A. J. , Jäntti, S. , Juuti, A. , Arola, J.
& et al.
(2021). Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. Journal of Hepatology.
Oresic, M. , Sen, P. , Quadri, S. , Luukkonen, P. , Ragnarsdottir, O. , Jäntti, S. , Juuti, A. , Arola, J.
& et al.
(2021). Exposure to environmental contaminants is associated with sex-specific disturbances of hepatic lipid metabolism in non-alcoholic fatty liver disease. Journal of Hepatology, 75 (Suppl. 2), S605-S606.
Lamichhane, S. , Siljander, H. , Duberg, D. , Honkanen, J. , Virtanen, S. M. , Oresic, M. , Knip, M.
& Hyötyläinen, T. (2021). Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk. Environment International, 157.
Wiegers, E. J. A. , Lingsma, H. F. , Huijben, J. A. , Cooper, D. J. , Citerio, G. , Frisvold, S. , Helbok, R. , Maas, A. I. R.
& et al.
(2021). Fluid balance and outcome in critically ill patients with traumatic brain injury (CENTER-TBI and OzENTER-TBI): a prospective, multicentre, comparative effectiveness study. Lancet Neurology, 20 (8), 627-638.
Andelic, N. , Røe, C. , Brunborg, C. , Zeldovich, M. , Løvstad, M. , Løke, D. , Borgen, I. M. , Voormolen, D. C.
& et al.
(2021). Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study. Journal of Neurology, 268 (1), 61-73.
Sen, P. , Govaere, O. , Sinioja, T. , McGlinchey, A. J. , Geng, D. , Ratziu, V. , Bugianesi, E. , Schattenberg, J.
& et al.
(2021). Genome-scale metabolic modeling of human hepatocytes reveals dysregulation of glycosphingolipid pathways in progressive non-alcoholic fatty liver disease. Journal of Hepatology, 75 (Suppl. 2), S256-S256.
Böhm, J. K. , Güting, H. , Thorn, S. , Schäfer, N. , Rambach, V. , Schöchl, H. , Grottke, O. , Rossaint, R.
& et al.
(2021). Global Characterisation of Coagulopathy in Isolated Traumatic Brain Injury (iTBI): A CENTER-TBI Analysis. Neurocritical Care, 35 (1), 184-196.
Andersson, L. , Cinato, M. , Mardani, I. , Miljanovic, A. , Arif, M. , Koh, A. , Lindbom, M. , Laudette, M.
& et al.
(2021). Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking. European Heart Journal.
Brial, F. , Chilloux, J. , Nielsen, T. , Vieira-Silva, S. , Falony, G. , Andrikopoulos, P. , Olanipekun, M. , Hoyles, L.
& et al.
(2021). Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health. Gut.
Lamichhane, S. , Sen, P. , Alves, M. A. , Ribeiro, H. C. , Raunioniemi, P. , Hyötyläinen, T.
& Oresic, M. (2021). Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations. Metabolites, 11 (1).
Hyötyläinen, T. , Bodin, J. , Duberg, D. , Dirven, H. , Nygaard, U. C.
& Oresic, M. (2021). Lipidomic Analyses Reveal Modulation of Lipid Metabolism by the PFAS Perfluoroundecanoic Acid (PFUnDA) in Non-Obese Diabetic Mice. Frontiers in Genetics, 12.
Citerio, G. , Robba, C. , Rebora, P. , Petrosino, M. , Rossi, E. , Malgeri, L. , Stocchetti, N. , Galimberti, S.
& et al.
(2021). Management of arterial partial pressure of carbon dioxide in the first week after traumatic brain injury: results from the CENTER-TBI study. Intensive Care Medicine.
Gravesteijn, B. Y. , Sewalt, C. A. , Venema, E. , Nieboer, D. , Steyerberg, E. W.
& Oresic, M. (2021). Missing Data in Prediction Research: A Five-Step Approach for Multiple Imputation, Illustrated in the CENTER-TBI Study. Journal of Neurotrauma, 38 (13), 1842-1857.
Oresic, M. (2021). Molecular lipids in prediction of psychosis and the associated cardiometabolic co-morbidities. European psychiatry, 64 (Suppl. 1), S16-S16.
van Veen, E. , van der Jagt, M. , Citerio, G. , Stocchetti, N. , Gommers, D. , Burdorf, A. , Menon, D. K. , Maas, A. I. R.
& et al.
(2021). Occurrence and timing of withdrawal of life-sustaining measures in traumatic brain injury patients: a CENTER-TBI study. Intensive Care Medicine.
Dijkland, S. A. , Helmrich, I. R. A. R. , Nieboer, D. , van der Jagt, M. , Dippel, D. W. J. , Menon, D. K. , Stocchetti, N. , Maas, A. I. R.
& et al.
(2021). Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients. Journal of Neurotrauma, 38 (10), 1377-1388.
Yuh, E. L. , Zafonte, R.
& Oresic, M. (2021). Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI. JAMA Neurology.
Fart, F. , Salihovic, S. , McGlinchey, A. J. , Gareau, M. G. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T.
& Schoultz, I. (2021). Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects ex vivo in murine intestinal tissue. Scandinavian Journal of Gastroenterology, 56 (11), 1286-1295.
Riemann, L. , Voormolen, D. C. , Rauen, K. , Zweckberger, K. , Unterberg, A. , Younsi, A.
& Oresic, M. (2021). Persistent postconcussive symptoms in children and adolescents with mild traumatic brain injury receiving initial head computed tomography. Journal of Neurosurgery: Pediatrics, 1-10.
Mikolić, A. , Polinder, S. , Steyerberg, E. W. , Retel Helmrich, I. R. A. , Giacino, J. T. , Maas, A. I. R. , van der Naalt, J. , Voormolen, D. C.
& et al.
(2021). Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study. Journal of Neurotrauma, 38 (2), 196-209.
Sewalt, C. A. , Gravesteijn, B. Y. , Menon, D. , Lingsma, H. F. , Maas, A. I. R. , Stocchetti, N. , Venema, E. , Lecky, F. E.
& et al.
(2021). Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 29 (1).
Franks, P. W. , Melén, E. , Friedman, M. , Sundström, J. , Kockum, I. , Klareskog, L. , Almqvist, C. , Bergen, S. E.
& et al.
(2021). Technological readiness and implementation of genomic-driven precision medicine for complex diseases. Journal of Internal Medicine.
McGlinchey, A. J. , Geng, D. , Govaere, O. , Ratziu, V. , Bugianesi, E. , Schattenberg, J. M. , Daley, A. , Hyötyläinen, T.
& et al.
(2021). The Metabolomics of Non-Alcoholic Fatty Liver Disease: Of Networks and Biomarkers. Journal of Hepatology, 75 (Suppl. 2), S579-S580.
Wilson, L. , Horton, L. , Kunzmann, K. , Sahakian, B. J. , Newcombe, V. F. , Stamatakis, E. A. , von Steinbuechel, N. , Cunitz, K.
& et al.
(2021). Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury.. Journal of Neurology, Neurosurgery and Psychiatry, 92, 407-417.
Salonurmi, T. , Nabil, H. , Ronkainen, J. , Hyötyläinen, T. , Hautajärvi, H. , Savolainen, M. J. , Tolonen, A. , Oresic, M.
& et al.
(2020). 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.. Frontiers in Pharmacology, 11.
Segal, E. , Oresic, M.
& Vilmes, P. (2020). Building an international consortium for tracking coronavirus health status. Nature Medicine, 26 (8), 1161-1165.
Feng, J. , van Veen, E. , Yang, C. , Huijben, J. A. , Lingsma, H. F. , Gao, G. , Jiang, J. , Maas, A. I. R.
& et al.
(2020). Comparison of Care System and Treatment Approaches for Patients with Traumatic Brain Injury in China versus Europe: A CENTER-TBI Survey Study. Journal of Neurotrauma, 37 (16), 1806-1817.
Xu, S. , Wu, B. , Oresic, M. , Xie, Y. , Yao, P. , Wu, Z. , Lv, X. , Chen, H.
& et al.
(2020). Double Derivatization Strategy for High-Sensitivity and High-Coverage Localization of Double Bonds in Free Fatty Acids by Mass Spectrometry. Analytical Chemistry, 92 (9), 6446-6455.
Sinisalu, L. , Sen, P. , Salihovic, S. , Virtanen, S. M. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2020). Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease. Environmental Research, 188.
Vali, Y. , Lee, J. , Boursier, J. , Spijker, R. , Löffler, J. , Verheij, J. , Brosnan, M. J. , Böcskei, Z.
& et al.
(2020). Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis. Journal of Hepatology, 73 (2), 252-262.
Anstee, Q. M. , Darlay, R. , Cockell, S. , Meroni, M. , Govaere, O. , Tiniakos, D. , Burt, A. D. , Bedossa, P.
& et al.
(2020). Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort. Journal of Hepatology, 73 (3), 505-515.
Voormolen, D. C. , Polinder, S. , von Steinbuechel, N. , Feng, Y. , Wilson, L. , Oppe, M. , Haagsma, J. A. , CENTER-TBI participants and investigators, -.
& et al.
(2020). Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom.. Quality of Life Research, 29 (11), 3095-3107.
Timmers, M. , van Dijck, J. T. J. M. , van Wijk, R. P. J. , Legrand, V. , van Veen, E. , Maas, A. I. R. , Menon, D. K. , Citerio, G.
& et al.
(2020). How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study. BMC Medical Ethics, 21 (1).
Luukkonen, P. K. , Tukiainen, T. , Juuti, A. , Sammalkorpi, H. , Haridas, P. A. N. , Niemelä, O. , Arola, J. , Orho-Melander, M.
& et al.
(2020). Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight, 5 (5).
Mathieu, F. , Güting, H. , Gravesteijn, B. , Monteiro, M. , Glocker, B. , Kornaropoulos, E. N. , Kamnistas, K. , Robertson, C. S.
& et al.
(2020). Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury: A CENTER-TBI Propensity-Matched Cohort Analysis. Journal of Neurotrauma, 37 (19), 2069-2080.
van Wijk, R. P. J. , van Dijck, J. T. J. M. , Timmers, M. , van Veen, E. , Citerio, G. , Lingsma, H. F. , Maas, A. I. R. , Menon, D. K.
& et al.
(2020). Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study. Journal of critical care, 59, 6-15.
Thomas, I. , Dickens, A. M. , Posti, J. P. , Mohammadian, M. , Ledig, C. , Takala, R. S. K. , Hyötyläinen, T. , Tenovuo, O.
& et al.
(2020). Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury. International Journal of Molecular Sciences, 21 (4).
Dickens, A. M. , Borgan, F. , Laurikainen, H. , Lamichhane, S. , Marques, T. , Rönkkö, T. , Veronese, M. , Lindeman, T.
& et al.
(2020). Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis. NPJ schizophrenia, 6 (1).
Gravesteijn, B. Y. , Nieboer, D. , Ercole, A. , Lingsma, H. F. , Nelson, D. , van Calster, B. , Steyerberg, E. W. , The CENTER-TBI collaborators, .
& et al.
(2020). Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury. Journal of Clinical Epidemiology, 122, 95-107.
Luukkonen, P. K. , Juuti, A. , Sammalkorpi, H. , Penttilä, A. K. , Oresic, M. , Hyötyläinen, T. , Arola, J. , Orho-Melander, M.
& et al.
(2020). MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology, 73 (3), 725-726.
Sen, P. , Dickens, A. M. , López-Bascón, M. A. , Lindeman, T. , Kemppainen, E. , Lamichhane, S. , Rönkkö, T. , Ilonen, J.
& et al.
(2020). Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia, 63 (5), 1017-1031.
Fart, F. , Salihovic, S. , McGlinchey, A. J. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T.
& Schoultz, I. (2020). Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis. Journal of Crohn's & Colitis, 14 (Suppl. 1), S138-S139.
Jacob, L. , Cogné, M. , Tenovuo, O. , Røe, C. , Andelic, N. , Majdan, M. , Ranta, J. , Ylen, P.
& et al.
(2020). Predictors of Access to Rehabilitation in the Year Following Traumatic Brain Injury: A European Prospective and Multicenter Study. Neurorehabilitation and Neural Repair, 34 (9), 814-830.
McGlinchey, A. J. , Sinioja, T. , Lamichhane, S. , Sen, P. , Bodin, J. , Siljander, H. , Dickens, A. M. , Geng, D.
& et al.
(2020). Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes. Environment International, 143.
Vande Vyvere, T. , De La Rosa, E. , Wilms, G. , Nieboer, D. , Steyerberg, E. , Maas, A. I. R. , Verheyden, J. , van den Hauwe, L.
& et al.
(2020). Prognostic Validation of the NINDS Common Data Elements for the Radiologic Reporting of Acute Traumatic Brain Injuries: A CENTER-TBI Study.. Journal of Neurotrauma, 37 (11), 1269-1282.
Segal, E. , Oresic, M.
& Wilmes, P. (2020). Publisher Correction: Building an international consortium for tracking coronavirus health status.. Nature Medicine, 26 (8).
Salihovic, S. , Dickens, A. M. , Schoultz, I. , Fart, F. , Sinisalu, L. , Lindeman, T. , Halfvarson, J. , Oresic, M.
& et al.
(2020). Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry, 412 (10), 2251-2259.
Qadri, S. , Lallukka-Brück, S. , Luukkonen, P. K. , Zhou, Y. , Gastaldelli, A. , Orho-Melander, M. , Sammalkorpi, H. , Juuti, A.
& et al.
(2020). The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue. Liver international (Print), 40 (9), 2128-2138.
Gravesteijn, B. Y. , Sewalt, C. A. , Ercole, A. , Akerlund, C. , Nelson, D. , Maas, A. I. R. , Menon, D. , Lingsma, H. F.
& et al.
(2020). Toward a New Multi-Dimensional Classification of Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Study. Journal of Neurotrauma, 37 (7), 1002-1010.
Gravesteijn, B. Y. , Sewalt, C. A. , Nieboer, D. , Menon, D. K. , Maas, A. , Lecky, F. , Klimek, M. , Lingsma, H. F.
& et al.
(2020). Tracheal intubation in traumatic brain injury: a multicentre prospective observational study. British Journal of Anaesthesia, 125 (4), 505-517.
Govaere, O. , Cockell, S. , Tiniakos, D. , Queen, R. , Younes, R. , Vacca, M. , Alexander, L. , Ravaioli, F.
& et al.
(2020). Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis. Science Translational Medicine, 12 (572).
Steyerberg, E. W. , Wiegers, E. , Sewalt, C. , Buki, A. , Citerio, G. , De Keyser, V. , Ercole, A. , Kunzmann, K.
& et al.
(2019). Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. Lancet Neurology, 18 (10), 923-934.
Vande Vyvere, T. , Wilms, G. , Claes, L. , Martin Leon, F. , Nieboer, D. , Verheyden, J. , van den Hauwe, L. , Pullens, P.
& et al.
(2019). Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research.. Journal of Neurotrauma, 36 (7), 1080-1092.
Lamichhane, S. , Kemppainen, E. , Trošt, K. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2019). Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia, 62 (12), 2287-2297.
Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Dickens, A. M. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J.
& et al.
(2019). Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules, 9 (1).
van Essen, T. A. , den Boogert, H. F. , Cnossen, M. C. , de Ruiter, G. C. W. , Haitsma, I. , Polinder, S. , Steyerberg, E. W. , Menon, D.
& et al.
(2019). Correction to: Variation in neurosurgical management of traumatic brain injury. Acta Neurochirurgica, 161 (3), 451-455.
Hernández-Alvarez, M. I. , Sebastián, D. , Vives, S. , Ivanova, S. , Bartoccioni, P. , Kakimoto, P. , Plana, N. , Veiga, S. R.
& et al.
(2019). Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell, 177 (4), 881-895.e17.
Geng, D. , Musse, A. A. , Wigh, V. , Carlsson, C. , Engwall, M. , Oresic, M. , Scherbak, N.
& Hyötyläinen, T. (2019). Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo. Ecotoxicology and Environmental Safety, 170, 691-698.
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& Korpela, R. A. (2012). Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects. European Journal of Clinical Nutrition, 66 (7), 843-849.
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Marinković, T. , Sysi-Aho, M.
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Jerby, L. , Wolf, L. , Denkert, C. , Stein, G. Y. , Hilvo, M. , Oresic, M. , Geiger, T.
& Ruppin, E. (2012). Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer. Cancer Research, 72 (22), 5712-5720.
Hyötyläinen, T. , Mattila, I. , Wiedmer, S. K. , Koivuniemi, A. , Taskinen, M. , Yki-Järvinen, H.
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Oresic, M. (2012). Metabolomics in the studies of islet autoimmunity and type 1 diabetes. The review of diabetic studies : RDS, 9 (4), 236-247.
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(2012). Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 109 (14), 5523-5528.
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Ketola, K. , Hilvo, M. , Hyötyläinen, T. , Vuoristo, A. , Ruskeepää, A. L. , Oresic, M. , Kallioniemi, O. P.
& Iljin, K. (2012). Salinomycin inhibits prostate cancer growth and migration via induction of oxidative stress. British Journal of Cancer, 106 (1), 99-106.
Pflueger, M. , Seppänen-Laakso, T. , Suortti, T. , Hyötyläinen, T. , Achenbach, P. , Bonifacio, E. , Oresic, M.
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de Mas, I. M. , Selivanov, V. A. , Marin, S. , Roca, J. , Oresic, M. , Agius, L.
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Castillo, S. , Mattila, I. , Miettinen, J. , Oresic, M.
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(2011). Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes, 60 (3), 797-809.
Aura, A. , Mattila, I. , Hyötyläinen, T. , Gopalacharyulu, P. , Bounsaythip, C. , Oresic, M.
& Oksman-Caldentey, K. (2011). Drug metabolome of the simvastatin formed by human intestinal microbiota in vitro. Molecular Biosystems, 7 (2), 437-446.
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Rantamäki, A. H. , Seppänen-Laakso, T. , Oresic, M. , Jauhiainen, M.
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Oresic, M. (2011). Informatics and computational strategies for the study of lipids. Biochimica et Biophysica Acta, 1811 (11), 991-999.
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Kankainen, M. , Gopalacharyulu, P. , Holm, L.
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(2011). Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy. PLOS ONE, 6 (1).
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Yetukuri, L. , Söderlund, S. , Koivuniemi, A. , Seppänen-Laakso, T. , Niemelä, P. S. , Hyvönen, M. , Taskinen, M. , Vattulainen, I.
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(2010). Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol. Journal of Lipid Research, 51 (8), 2341-2351.
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(2010). Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome. NMCD. Nutrition Metabolism and Cardiovascular Diseases, 20 (4), 249-57.
Leskinen, T. , Rinnankoski-Tuikka, R. , Rintala, M. , Seppänen-Laakso, T. , Pöllänen, E. , Alen, M. , Sipilä, S. , Kaprio, J.
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(2010). Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs. PLOS ONE, 5 (9).
López, M. , Varela, L. , Vázquez, M. J. , Rodríguez-Cuenca, S. , González, C. R. , Velagapudi, V. R. , Morgan, D. A. , Schoenmakers, E.
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(2010). Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature Medicine, 16 (9), 1001-1008.
Ahola-Erkkilä, S. , Carroll, C. J. , Peltola-Mjösund, K. , Tulkki, V. , Mattila, I. , Seppänen-Laakso, T. , Oresic, M. , Tyynismaa, H.
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(2010). Ketogenic diet slows down mitochondrial myopathy progression in mice. Human Molecular Genetics, 19 (10), 1974-1984.
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Huopaniemi, I. , Suvitaival, T. , Nikkilä, J. , Oresic, M.
& Kaski, S. (2010). Multivariate multi-way analysis of multi-source data. Bioinformatics, 26 (12), i391-i398.
Pluskal, T. , Castillo, S. , Villar-Briones, A.
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Hall, D. , Poussin, C. , Velagapudi, V. R. , Empsen, C. , Joffraud, M. , Beckmann, J. S. , Geerts, A. E. , Ravussin, Y.
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(2010). Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.. International Journal of Obesity, 34 (12), 1695-1705.
Westerbacka, J. , Kotronen, A. , Fielding, B. A. , Wahren, J. , Hodson, L. , Perttilä, J. , Seppänen-Laakso, T. , Suortti, T.
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(2010). Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. Gastroenterology, 139 (6), 1961-1971.e1.
Oresic, M. (2010). Systems biology strategy to study lipotoxicity and the metabolic syndrome. Biochimica et Biophysica Acta, 1801 (3), 235-239.
Oresic, M. , Lötjönen, J.
& Soininen, H. (2010). Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease. Genome Medicine, 2 (11).
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Medina-Gomez, G. , Yetukuri, L. , Velagapudi, V. , Campbell, M. , Blount, M. , Jimenez-Linan, M. , Ros, M. , Oresic, M.
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(2009). Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Disease Models and Mechanisms, 2 (11-12), 582-592.
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(2009). ApoCIII-enriched LDL in type 2 diabetes displays altered lipid composition, increased susceptibility for sphingomyelinase, and increased binding to biglycan. Diabetes, 58 (9), 2018-2026.
Niemelä, P. S. , Castillo, S. , Sysi-Aho, M.
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Wheelock, C. E. , Goto, S. , Yetukuri, L. , D'Alexandri, F. L. , Klukas, C. , Schreiber, F.
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Lindfors, E. , Gopalacharyulu, P. V. , Halperin, E.
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Gopalacharyulu, P. V. , Velagapudi, V. R. , Lindfors, E. , Halperin, E.
& Oresic, M. (2009). Dynamic network topology changes in functional modules predict responses to oxidative stress in yeast. Molecular Biosystems, 5 (3), 276-287.
Kajander, K. , Myllyluoma, E. , Kyrönpalo, S. , Rasmussen, M. , Sipponen, P. , Mattila, I. , Seppänen-Laakso, T. , Vapaatalo, H.
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(2009). Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome. World Journal of Gastroenterology, 15 (48), 6068-6074.
Lankinen, M. , Schwab, U. , Erkkilä, A. , Seppänen-Laakso, T. , Hannila, M. , Mussalo, H. , Lehto, S. , Uusitupa, M.
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(2009). Fatty fish intake decreases lipids related to inflammation and insulin signaling: a lipidomics approach. PLOS ONE, 4 (4).
Oresic, M. , Seppänen-Laakso, T. , Yetukuri, L. , Bäckhed, F.
& Hänninen, V. (2009). Gut microbiota affects lens and retinal lipid composition. Experimental Eye Research, 89 (5), 604-607.
Kotronen, A. , Seppänen-Laakso, T. , Westerbacka, J. , Kiviluoto, T. , Arola, J. , Ruskeepää, A. , Oresic, M.
& Yki-Järvinen, H. (2009). Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes, 58 (1), 203-208.
Tang, J. , Tan, C. Y. , Oresic, M.
& Vidal-Puig, A. (2009). Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Medicine, 1 (3).
Gatfield, D. , Le Martelot, G. , Vejnar, C. E. , Gerlach, D. , Schaad, O. , Fleury-Olela, F. , Ruskeepää, A. , Oresic, M.
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(2009). Integration of microRNA miR-122 in hepatic circadian gene expression. Genes & Development, 23 (11), 1313-26.
de Mello, V. D. F. , Lankinen, M. , Schwab, U. , Kolehmainen, M. , Lehto, S. , Seppänen-Laakso, T. , Oresic, M. , Pulkkinen, L.
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(2009). Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease. Diabetologia, 52 (12), 2612-2615.
Oresic, M. (2009). Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction. NMCD. Nutrition Metabolism and Cardiovascular Diseases, 19 (11), 816-824.
Nath, A. K. , Krauthammer, M. , Li, P. , Davidov, E. , Butler, L. C. , Copel, J. , Katajamaa, M. , Oresic, M.
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Róg, T. , Martinez-Seara, H. , Munck, N. , Oresic, M. , Karttunen, M.
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Gopalacharyulu, P. V. , Lindfors, E. , Miettinen, J. , Bounsaythip, C. K.
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Mattila, I. , Seppänen-Laakso, T. , Suortti, T.
& Oresic, M. (2008). Application of lipidomics and metabolomics to the study of adipose tissue. Methods in Molecular Biology, 456, 123-130.
Minehira, K. , Young, S. G. , Villanueva, C. J. , Yetukuri, L. , Oresic, M. , Hellerstein, M. K. , Farese, R. V. , Horton, J. D.
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& Oresic, M. (2008). Capillary electrophoresis with UV detection and mass spectrometry in method development for profiling metabolites of steroid hormone metabolism. Journal of chromatography. B, 871 (2), 375-382.
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(2008). Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. Journal of Experimental Medicine, 205 (13), 2975-2984.
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(2008). Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data. Radiology, 249 (1), 88-96.
Kekkonen, R. , Sysi-Aho, M. , Seppanen-Laakso, T. , Julkunen, I. , Vapaatalo, H. , Oresic, M.
& Korpela, R. (2008). Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults. World Journal of Gastroenterology, 14 (20), 3188-3194.
Nikkilä, J. , Sysi-Aho, M. , Ermolov, A. , Seppänen-Laakso, T. , Simell, O. , Kaski, S.
& Oresic, M. (2008). Gender-dependent progression of systemic metabolic states in early childhood. Molecular Systems Biology, 4.
Pietiläinen, K. H. , Naukkarinen, J. , Rissanen, A. , Saharinen, J. , Ellonen, P. , Keränen, H. , Suomalainen, A. , Götz, A.
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Yetukuri, L. , Ekroos, K. , Vidal-Puig, A.
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Oresic, M. , Hänninen, V. A.
& Vidal-Puig, A. (2008). Lipidomics: a new window to biomedical frontiers. Trends in Biotechnology, 26 (12), 647-652.
Laaksonen, R. , Jänis, M. T.
& Oresic, M. (2008). Lipidomics-based safety biomarkers for lipid-lowering treatments. Angiology, 59 (2 Suppl), 65S-68S.
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(2008). Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circulation Research, 103 (9), 1018-1026.
Schwab, U. , Seppänen-Laakso, T. , Yetukuri, L. , Ågren, J. , Kolehmainen, M. , Laaksonen, D. E. , Ruskeepää, A. , Gylling, H.
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Pietiläinen, K. H. , Sysi-Aho, M. , Rissanen, A. , Seppänen-Laakso, T. , Yki-Järvinen, H. , Kaprio, J.
& Oresic, M. (2007). Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects: a monozygotic twin study. PLOS ONE, 2 (2).
Kolak, M. , Westerbacka, J. , Velagapudi, V. R. , Wågsäter, D. , Yetukuri, L. , Makkonen, J. , Rissanen, A. , Häkkinen, A.
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(2007). Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes, 56 (8), 1960-1968.
Yetukuri, L. , Katajamaa, M. , Medina-Gomez, G. , Seppänen-Laakso, T. , Vidal-Puig, A.
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Sysi-Aho, M. , Katajamaa, M. , Yetukuri, L.
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Medina-Gomez, G. , Gray, S. L. , Yetukuri, L. , Shimomura, K. , Virtue, S. , Campbell, M. , Curtis, R. K. , Jimenez-Linan, M.
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Elo, L. L. , Järvenpää, H. , Oresic, M. , Lahesmaa, R.
& Aittokallio, T. (2007). Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process. Bioinformatics, 23 (16), 2096-2103.
Laaksonen, R. , Katajamaa, M. , Päivä, H. , Sysi-Aho, M. , Saarinen, L. , Junni, P. , Lütjohann, D. , Smet, J.
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Oresic, M. , Vidal-Puig, A.
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Katajamaa, M. , Miettinen, J.
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Artiklar, forskningsöversikter
Kyle, J. E. , Aimo, L. , Bridge, A. J. , Clair, G. , Fedorova, M. , Helms, J. B. , Molenaar, M. R. , Ni, Z.
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Oresic, M. , McGlinchey, A. J. , Wheelock, C. E.
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Fang, W. , Santosh, L. , Oresic, M.
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Sen, P.
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Sen, P. , Kempainen, E.
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Posti, J. P. , Dickens, A. M. , Orešič, M. , Hyötyläinen, T.
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Rodriguez-Cuenca, S. , Pellegrinelli, V. , Campbell, M. , Oresic, M.
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Marinković, T.
& Oresic, M. (2016). Modeling strategies to study metabolic pathways in progression to type 1 diabetes: Challenges and opportunities. Archives of Biochemistry and Biophysics, 589, 131-7.
Hyötyläinen, T.
& Oresic, M. (2015). Optimizing the lipidomics workflow for clinical studies: practical considerations. Analytical and Bioanalytical Chemistry, 407 (17), 4973-4993.
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& Oresic, M. (2014). Systems biology strategies to study lipidomes in health and disease. Progress in lipid research, 55 (1), 43-60.
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Jänis, M. T. , Laaksonen, R.
& Oresic, M. (2008). Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs. Expert Opinion on Drug Metabolism & Toxicology, 4 (6), 665-680.
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Kapitel i böcker, del av antologier
Lamichhane, S. , Sen, P. , Dickens, A. M. , Hyötyläinen, T.
& Orešič, M. (2018). An Overview of Metabolomics Data Analysis: Current Tools and Future Perspectives.
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