Matej Oresic
Tjänstetitel: Universitetslektor Organisation: Institutionen för medicinska vetenskaper
E-post:
Telefon: 019 302137
Rum: C2201
Om Matej Oresic
Matej Orešič har en doktorsexamen i biofysik från Cornell University. Han är en gästlektor vid Örebro Universitet, samt gruppledare inom systems medicin vid Åbo Centrum för Bioteknik, Åbo Universitet och en huvudforskare vid Finlands Akademis Centrum för Excellens inom Molekylär System Immunologi och Fysiologiforskning.
Matejs forskning är framför allt inriktad mot metabolomik inom biomedicin och integrativ bioinformatik. Fokus ligger på identifieringen av sjukdomssårbarheter associerade med olika metaboliska fenotyper och de underliggande mekanismerna som kopplar samman dessa sårbarheter med utvecklingen av specifika störningar, med särskild inriktning på fetma och diabetes och deras co-morbiditeter.
Dr. Orešič har också initierat det populära MZmine open source-projektet, vilket har lett till en populär mjukvara för databehandling av metabolomics. Tidigare, Dr. Orešič var huvudforskare vid Steno Diabetes Center (Gentofte, Danmark), forskarprofessor vid VTT Tekniska Forskningscentralen i Finland (Esbo, Finland), chef för beräkningsbiologi och modellering vid Beyond Genomics, Inc. (Waltham / MA) Och bioinformatiker vid LION Bioscience Research i Cambridge / MA. År 2016 fick Dr. Oresic livstidens honorärmedlemspris från Metabolomics Society. Han är medgrundare och för närvarande styrelseordförande för Nordic Metabolomics Society.
Dr Oresic har nyligen varit ordförande för två internationella metabolomikmöten:
- 1st Nordic Metabolomics Conference (Örebro, Sweden, August 26-28, 2018)
- Gordon Research Conference - Metabolomics and Human Health (Ventura, CA, USA, February 3-8, 2019)
Forskningsprojekt
Forskningsprojekt
- Blodbaserad metabolomik för att förutsäga svårighetsgrad och patient prognos vid traumatisk hjärnskada (meTBI)
- EPoS - Elucidating Pathways of Steatohepatitis
- Human exposure to per- and polyfluoroalkyl substances? Role of the gut microbiome and bile acid metabolism in mediating impact (PFASgut)
- Hälsoeffekter av miljöexponering tidigt i livet
- Lipid pathways en route to islet autoimmunity and type 1 diabetes
- LipidNET- Pan-European Network in Lipidomics and Epilipidomics?
- LITMUS
- Metabolomic and Proteomic markers staging progression to type 1 diabetes in autoantibody positive children
- Mother-infant interactions in relation to potential biomarkers of beta-cell autoimmunity and type 1 diabetes
Forskargrupper
Forskargrupper
Publikationer
Publikationer
Artiklar i tidskrifter |
Artiklar, forskningsöversikter |
Kapitel i böcker, del av antologier |
Artiklar i tidskrifter
Salonurmi, T. , Nabil, H. , Ronkainen, J. , Hyötyläinen, T. , Hautajärvi, H. , Savolainen, M. J. , Tolonen, A. , Oresic, M.
& et al.
(2020). 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters.. Frontiers in Pharmacology, 11.
Lamichhane, S. , Dickens, A. M. , Sen, P. , Laurikainen, H. , Borgan, F. , Suvisaari, J. , Hyötyläinen, T. , Howes, O.
& et al.
(2020). Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis.. Schizophrenia Bulletin.
Huie, J. R. , Mondello, S. , Lindsell, C. J. , Antiga, L. , Yuh, E. L. , Zanier, E. R. , Masson, S. , Rosario, B. L.
& et al.
(2020). Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations. Journal of Neurotrauma.
Segal, E. , Oresic, M.
& Vilmes, P. (2020). Building an international consortium for tracking coronavirus health status. Nature Medicine.
Feng, J. , van Veen, E. , Yang, C. , Huijben, J. A. , Lingsma, H. F. , Gao, G. , Jiang, J. , Maas, A. I. R.
& et al.
(2020). Comparison of Care System and Treatment Approaches for Patients with Traumatic Brain Injury in China versus Europe: A CENTER-TBI Survey Study. Journal of Neurotrauma.
Xu, S. , Wu, B. , Oresic, M. , Xie, Y. , Yao, P. , Wu, Z. , Lv, X. , Chen, H.
& et al.
(2020). Double Derivatization Strategy for High-Sensitivity and High-Coverage Localization of Double Bonds in Free Fatty Acids by Mass Spectrometry. Analytical Chemistry, 92 (9), 6446-6455.
Vali, Y. , Lee, J. , Boursier, J. , Spijker, R. , Löffler, J. , Verheij, J. , Brosnan, M. J. , Böcskei, Z.
& et al.
(2020). Enhanced liver fibrosis test for the non-invasive diagnosis of fibrosis in patients with NAFLD: A systematic review and meta-analysis. Journal of Hepatology.
Andelic, N. , Røe, C. , Brunborg, C. , Zeldovich, M. , Løvstad, M. , Løke, D. , Borgen, I. M. , Voormolen, D. C.
& et al.
(2020). Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study. Journal of Neurology.
Anstee, Q. M. , Darlay, R. , Cockell, S. , Meroni, M. , Govaere, O. , Tiniakos, D. , Burt, A. D. , Bedossa, P.
& et al.
(2020). Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically-characterised cohort. Journal of Hepatology.
Voormolen, D. C. , Polinder, S. , von Steinbuechel, N. , Feng, Y. , Wilson, L. , Oppe, M.
& Haagsma, J. A. (2020). Health-related quality of life after traumatic brain injury: deriving value sets for the QOLIBRI-OS for Italy, The Netherlands and The United Kingdom.. Quality of Life Research.
Timmers, M. , van Dijck, J. T. J. M. , van Wijk, R. P. J. , Legrand, V. , van Veen, E. , Maas, A. I. R. , Menon, D. K. , Citerio, G.
& et al.
(2020). How do 66 European institutional review boards approve one protocol for an international prospective observational study on traumatic brain injury? Experiences from the CENTER-TBI study. BMC Medical Ethics, 21 (1).
Luukkonen, P. K. , Tukiainen, T. , Juuti, A. , Sammalkorpi, H. , Haridas, P. A. N. , Niemelä, O. , Arola, J. , Orho-Melander, M.
& et al.
(2020). Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease. JCI Insight, 5 (5).
Mathieu, F. , Güting, H. , Gravesteijn, B. , Monteiro, M. , Glocker, B. , Kornaropoulos, E. N. , Kamnistas, K. , Robertson, C. S.
& et al.
(2020). Impact of Antithrombotic Agents on Radiological Lesion Progression in Acute Traumatic Brain Injury: A CENTER-TBI Propensity-Matched Cohort Analysis.. Journal of Neurotrauma.
van Wijk, R. P. J. , van Dijck, J. T. J. M. , Timmers, M. , van Veen, E. , Citerio, G. , Lingsma, H. F. , Maas, A. I. R. , Menon, D. K.
& et al.
(2020). Informed consent procedures in patients with an acute inability to provide informed consent: Policy and practice in the CENTER-TBI study.. Journal of critical care, 59, 6-15.
Thomas, I. , Dickens, A. M. , Posti, J. P. , Mohammadian, M. , Ledig, C. , Takala, R. S. K. , Hyötyläinen, T. , Tenovuo, O.
& et al.
(2020). Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury. International Journal of Molecular Sciences, 21 (4).
Gravesteijn, B. Y. , Nieboer, D. , Ercole, A. , Lingsma, H. F. , Nelson, D. , van Calster, B. , Steyerberg, E. W.
& The CENTER-TBI collaborators, . (2020). Machine learning algorithms performed no better than regression models for prognostication in traumatic brain injury. Journal of Clinical Epidemiology, 122, 95-107.
Luukkonen, P. K. , Juuti, A. , Sammalkorpi, H. , Penttilä, A. K. , Oresic, M. , Hyötyläinen, T. , Arola, J. , Orho-Melander, M.
& et al.
(2020). MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology.
Sen, P. , Dickens, A. M. , López-Bascón, M. A. , Lindeman, T. , Kemppainen, E. , Lamichhane, S. , Rönkkö, T. , Ilonen, J.
& et al.
(2020). Metabolic alterations in immune cells associate with progression to type 1 diabetes. Diabetologia, 63 (5), 1017-1031.
Fart, F. , Salihovic, S. , McGlinchey, A. J. , Oresic, M. , Halfvarson, J. , Hyötyläinen, T.
& Schoultz, I. (2020). Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis. Journal of Crohn's & Colitis, 14 (Suppl. 1), S138-S139.
McGlinchey, A. J. , Sinioja, T. , Lamichhane, S. , Sen, P. , Bodin, J. , Siljander, H. , Dickens, A. M. , Geng, D.
& et al.
(2020). Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes.. Environment International, 143.
Vande Vyvere, T. , De La Rosa, E. , Wilms, G. , Nieboer, D. , Steyerberg, E. , Maas, A. I. R. , Verheyden, J. , van den Hauwe, L.
& et al.
(2020). Prognostic Validation of the NINDS Common Data Elements for the Radiologic Reporting of Acute Traumatic Brain Injuries: A CENTER-TBI Study.. Journal of Neurotrauma.
Qadri, S. , Lallukka-Brück, S. , Luukkonen, P. K. , Zhou, Y. , Gastaldelli, A. , Orho-Melander, M. , Sammalkorpi, H. , Juuti, A.
& et al.
(2020). The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue. Liver international (Print).
Gravesteijn, B. Y. , Sewalt, C. A. , Ercole, A. , Akerlund, C. , Nelson, D. , Maas, A. I. R. , Menon, D. , Lingsma, H. F.
& et al.
(2020). Toward a New Multi-Dimensional Classification of Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research for Traumatic Brain Injury Study. Journal of Neurotrauma, 37 (7), 1002-1010.
Steyerberg, E. W. , Wiegers, E. , Sewalt, C. , Buki, A. , Citerio, G. , De Keyser, V. , Ercole, A. , Kunzmann, K.
& et al.
(2019). Case-mix, care pathways, and outcomes in patients with traumatic brain injury in CENTER-TBI: a European prospective, multicentre, longitudinal, cohort study. Lancet Neurology, 18 (10), 923-934.
Vande Vyvere, T. , Wilms, G. , Claes, L. , Martin Leon, F. , Nieboer, D. , Verheyden, J. , van den Hauwe, L. , Pullens, P.
& et al.
(2019). Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research.. Journal of Neurotrauma, 36 (7), 1080-1092.
Lamichhane, S. , Kemppainen, E. , Trošt, K. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2019). Circulating metabolites in progression to islet autoimmunity and type 1 diabetes. Diabetologia, 62 (12), 2287-2297.
Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Dickens, A. M. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J.
& et al.
(2019). Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes. Biomolecules, 9 (1).
van Essen, T. A. , den Boogert, H. F. , Cnossen, M. C. , de Ruiter, G. C. W. , Haitsma, I. , Polinder, S. , Steyerberg, E. W. , Menon, D.
& et al.
(2019). Correction to: Variation in neurosurgical management of traumatic brain injury. Acta Neurochirurgica, 161 (3), 451-455.
Hernández-Alvarez, M. I. , Sebastián, D. , Vives, S. , Ivanova, S. , Bartoccioni, P. , Kakimoto, P. , Plana, N. , Veiga, S. R.
& et al.
(2019). Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. Cell, 177 (4), 881-895.e17.
Geng, D. , Musse, A. A. , Wigh, V. , Carlsson, C. , Engwall, M. , Oresic, M. , Scherbak, N.
& Hyötyläinen, T. (2019). Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo. Ecotoxicology and Environmental Safety, 170, 691-698.
Luukkonen, P. K. , Nick, A. , Hölttä-Vuori, M. , Thiele, C. , Isokuortti, E. , Lallukka-Brück, S. , Zhou, Y. , Hakkarainen, A.
& et al.
(2019). Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids. JCI Insight, 4 (16).
Madrid-Gambin, F. , Focking, M. , Sabherwal, S. , Heurich, M. , English, J. A. , O'Gorman, A. , Suvitaival, T. , Ahonen, L.
& et al.
(2019). Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children. Biological Psychiatry, 86 (1), 25-34.
Playdon, M. C. , Joshi, A. D. , Tabung, F. K. , Cheng, S. , Henglin, M. , Kim, A. , Lin, T. , van Roekel, E. H.
& et al.
(2019). Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS). Metabolites, 9 (7).
Sen, P. , Carlsson, C. , Virtanen, S. M. , Simell, S. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2019). Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease. Clinical and Translational Gastroenterology, 10.
Salihovic, S. , Dickens, A. M. , Schoultz, I. , Fart, F. , Sinisalu, L. , Lindeman, T. , Halfvarson, J. , Oresic, M.
& et al.
(2019). Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry. Analytical and Bioanalytical Chemistry.
Ahonen, L. , Jäntti, S. , Suvitaival, T. , Theilade, S. , Risz, C. , Kostiainen, R. , Rossing, P. , Oresic, M.
& et al.
(2019). Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients. Metabolites, 9 (9).
Yu, B. , Oresic, M.
& Moore, S. C. (2019). The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies. American Journal of Epidemiology, 188 (6), 991-1012.
Sen, P. , Lamichhane, S. , Dickens, A.
& Oresic, M. (2019). The Role of Omic Technologies in the Study of the Human Gut Microbiome. Reference Module in Food Science.
Pedersen, H. K. , Forslund, S. K. , Gudmundsdottir, V. , Østergaard Petersen, A. , Hildebrand, F. , Hyötyläinen, T. , Nielsen, T. , Hansen, T.
& et al.
(2018). A computational framework to integrate high-throughput '-omics' datasets for the identification of potential mechanistic links. Nature Protocols, 13 (12), 2781-2800.
Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J. , Veijola, R.
& et al.
(2018). A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes. Scientific Data, 5.
Schwarz, E. , Maukonen, J. , Hyytiäinen, T. , Kieseppä, T. , Oresic, M. , Sabunciyan, S. , Mantere, O. , Saarela, M.
& et al.
(2018). Analysis of microbiota in first episode psychosis identifies preliminary associations with symptom severity and treatment response. Schizophrenia Research, 192, 398-403.
Lamichhane, S. , Ahonen, L. , Dyrlund, T. S. , Kemppainen, E. , Siljander, H. , Hyöty, H. , Ilonen, J. , Toppari, J.
& et al.
(2018). Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP). Scientific Reports, 8.
Lamichhane, S. , Sen, P. , Dickens, A. M. , Oresic, M.
& Bertram, H. C. (2018). Gut metabolome meets microbiome: A methodological perspective to understand the relationship between host and microbe. Methods, 149, 3-12.
Suvitaival, T. , Bondia-Pons, I. , Yetukuri, L. , Pöhö, P. , Nolan, J. J. , Hyötyläinen, T. , Kuusisto, J.
& Orešič, M. (2018). Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men. Metabolism: Clinical and Experimental, 78 (January), 1-12.
Burla, B. , Arita, M. , Arita, M. , Bendt, A. K. , Cazenave-Gassiot, A. , Dennis, E. A. , Ekroos, K. , Han, X.
& et al.
(2018). MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines. Journal of Lipid Research, 59 (10), 2001-2017.
Frank, E. , Maier, D. , Pajula, J. , Suvitaival, T. , Borgan, F. , Butz-Ostendorf, M. , Fischer, A. , Hietala, J.
& et al.
(2018). Platform for systems medicine research and diagnostic applications in psychotic disorders - The METSY project. European psychiatry, 50, 40-46.
Luukkonen, P. K. , Sädevirta, S. , Zhou, Y. , Kayser, B. , Ali, A. , Ahonen, L. , Lallukka, S. , Pelloux, V.
& et al.
(2018). Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. Diabetes Care, 41 (8), 1732-1739.
Dickens, A. M. , Posti, J. P. , Takala, R. S. , Ala-Seppälä, H. M. , Mattila, I. , Coles, J. C. , Frantzén, J. , Hutchinson, P. J.
& et al.
(2018). Serum Metabolites Associated with Computed TomographyFindings after Traumatic Brain Injury. Journal of Neurotrauma, 35 (22), 2673-2683.
Grip, T. , Dyrlund, T. S. , Ahonen, L. , Domellöf, M. , Hernell, O. , Hyötyläinen, T. , Knip, M. , Lönnerdal, B.
& et al.
(2018). Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes. Pediatric Research, 84 (5), 726-732.
Oresic, M. , Anderson, G. , Mattila, I. , Manoucheri, M. , Soininen, H. , Hyötyläinen, T.
& Basignani, C. (2018). Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor. Frontiers in Neuroscience, 11.
OʼConnell, B. , Kelly, Á. M. , Mockler, D. , Oresic, M. , Denvir, K. , Farrell, G. , Janigro, D.
& Wilson, F. (2018). Use of Blood Biomarkers in the Assessment of Sports-Related Concussion-A Systematic Review in the Context of Their Biological Significance. Clinical Journal of Sports Medicine, 28 (6), 561-571.
Bowden, J. A. , Hyötyläinen, T. , Oresic, M.
& Zhou, S. (2017). Harmonizing Lipidomics: NIST Interlaboratory Comparison Exercise for Lipidomics using Standard Reference Material 1950 Metabolites in Frozen Human Plasma. Journal of Lipid Research, 58 (12), 2275-2288.
Martínez-Sánchez, N. , Seoane-Collazo, P. , Contreras, C. , Varela, L. , Villarroya, J. , Rial-Pensado, E. , Buqué, X. , Aurrekoetxea, I.
& et al.
(2017). Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metabolism, 26 (1), 212-229.e12.
O'Gorman, A. , Suvitaival, T. , Ahonen, L. , Cannon, M. , Zammit, S. , Lewis, G. , Roche, H. M. , Mattila, I.
& et al.
(2017). Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Translational Psychiatry, 7.
Luukkonen, P. K. , Zhou, Y. , Haridas, N. P. A. , Dwivedi, O. P. , Hyötyläinen, T. , Ali, A. , Juuti, A. , Leivonen, M.
& et al.
(2017). Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. Journal of Hepatology, 67 (1), 128-136.
Hyötyläinen, T. , Ahonen, L. , Pöhö, P.
& Oresic, M. (2017). Lipidomics in biomedical research-practical considerations. Biochimica et Biophysica Acta, 1862 (8), 800-803.
Jørgenrud, B. , Stene, L. C. , Tapia, G. , Bøås, H. , Pepaj, M. , Berg, J. P. , Thorsby, P. M. , Orešič, M.
& et al.
(2017). Longitudinal plasma metabolic profiles, infant feeding, and islet autoimmunity in the MIDIA study. Pediatric Diabetes, 18 (2), 111-119.
Duszka, K. , Oresic, M. , Le May, C. , König, J.
& Wahli, W. (2017). PPARγ Modulates Long Chain Fatty Acid Processing in the Intestinal Epithelium. International Journal of Molecular Sciences, 18 (12).
Lankinen, M. , Schwab, U. , Kolehmainen, M. , Paananen, J. , Nygren, H. , Seppänen-Laakso, T. , Poutanen, K. , Hyötyläinen, T.
& et al.
(2016). A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention. Journal of Nutrition, 146 (4), 662-672.
Hyötyläinen, T.
& Orešič, M. (2016). Bioanalytical techniques in nontargeted clinical lipidomics. Bioanalysis, 8 (4), 351-364.
Rocca-Serra, P. , Salek, R. M. , Arita, M. , Correa, E. , Dayalan, S. , Gonzalez-Beltran, A. , Ebbels, T. , Goodacre, R.
& et al.
(2016). Data standards can boost metabolomics research, and if there is a will, there is a way. Metabolomics, 12.
Hyötyläinen, T. , Jerby, L. , Petäjä, E. M. , Mattila, I. , Jäntti, S. , Auvinen, P. , Gastaldelli, A. , Yki-Järvinen, H.
& et al.
(2016). Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease. Nature Communications, 7.
Luukkonen, P. K. , Zhou, Y. , Sädevirta, S. , Leivonen, M. , Arola, J. , Oresic, M. , Hyötyläinen, T.
& Yki-Järvinen, H. (2016). Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease. Journal of Hepatology, 64 (5), 1167-1175.
Pedersen, H. K. , Gudmundsdottir, V. , Nielsen, H. B. , Hyötyläinen, T. , Nielsen, T. , Jensen, B. A. H. , Forslund, K. , Hildebrand, F.
& et al.
(2016). Human gut microbes impact host serum metabolome and insulin sensitivity. Nature, 535 (7612), 376-381.
Oresic, M. , Posti, J. P. , Kamstrup-Nielsen, M. H. , Takala, R. S. K. , Lingsma, H. F. , Mattila, I. , Jäntti, S. , Katila, A. J.
& et al.
(2016). Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury. EBioMedicine, 12, 118-126.
Kurko, J. , Tringham, M. , Tanner, L. , Näntö-Salonen, K. , Vähä-Mäkilä, M. , Nygren, H. , Pöhö, P. , Lietzen, N.
& et al.
(2016). Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI). Metabolism: Clinical and Experimental, 65 (9), 1361-1375.
Caesar, R. , Nygren, H. , Orešič, M.
& Bäckhed, F. (2016). Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism. Journal of Lipid Research, 57 (3), 474-481.
Vetrani, C. , Rivellese, A. A. , Annuzzi, G. , Adiels, M. , Borén, J. , Mattila, I. , Oresic, M.
& Aura, A. (2016). Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites. Journal of Nutritional Biochemistry, 33, 111-118.
Beger, R. D. , Dunn, W. , Schmidt, M. A. , Gross, S. S. , Kirwan, J. A. , Cascante, M. , Brennan, L. , Wishart, D. S.
& et al.
(2016). Metabolomics enables precision medicine: "A White Paper, Community Perspective". Metabolomics, 12 (10).
Zhou, Y. , Oresic, M. , Leivonen, M. , Gopalacharyulu, P. , Hyysalo, J. , Arola, J. , Verrijken, A. , Francque, S.
& et al.
(2016). Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites. Clinical Gastroenterology and Hepatology, 14 (10), 1463-1472.e6.
Aho, V. , Ollila, H. M. , Kronholm, E. , Bondia-Pons, I. , Soininen, P. , Kangas, A. J. , Hilvo, M. , Seppälä, I.
& et al.
(2016). Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses. Scientific Reports, 6.
Luukkonen, P. K. , Zhou, Y. , Hyötyläinen, T. , Leivonen, M. , Arola, J. , Orho-Melander, M. , Oresic, M.
& Yki-Järvinen, H. (2016). The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans. Journal of Hepatology, 65 (6), 1263-1265.
Hyötyläinen, T.
& Orešič, M. (2015). Analytical Lipidomics in Metabolic and Clinical Research. Trends in endocrinology and metabolism, 26 (12), 671-673.
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(2011). Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Research, 71 (9), 3236-45.
Vainio, P. , Lehtinen, L. , Mirtti, T. , Hilvo, M. , Seppänen-Laakso, T. , Virtanen, J. , Sankila, A. , Nordling, S.
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(2011). Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. OncoTarget, 2 (12), 1176-1190.
Bondia-Pons, I. , Nordlund, E. , Mattila, I. , Katina, K. , Aura, A. , Kolehmainen, M. , Oresic, M. , Mykkänen, H.
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(2011). Postprandial differences in the plasma metabolome of healthy Finnish subjects after intake of a sourdough fermented endosperm rye bread versus white wheat bread. Nutrition Journal, 10.
Sysi-Aho, M. , Koikkalainen, J. , Seppänen-Laakso, T. , Kaartinen, M. , Kuusisto, J. , Peuhkurinen, K. , Kärkkäinen, S. , Antila, M.
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(2011). Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy. PLoS ONE, 6 (1).
Lankinen, M. , Schwab, U. , Kolehmainen, M. , Paananen, J. , Poutanen, K. , Mykkänen, H. , Seppänen-Laakso, T. , Gylling, H.
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(2011). Whole grain products, fish and bilberries alter glucose and lipid metabolism in a randomized, controlled trial: the Sysdimet study. PLoS ONE, 6 (8).
Kotronen, A. , Seppänen-Laakso, T. , Westerbacka, J. , Kiviluoto, T. , Arola, J. , Ruskeepää, A. , Yki-Järvinen, H.
& Oresic, M. (2010). Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum. Obesity, 18 (5), 937-944.
Yetukuri, L. , Söderlund, S. , Koivuniemi, A. , Seppänen-Laakso, T. , Niemelä, P. S. , Hyvönen, M. , Taskinen, M. , Vattulainen, I.
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(2010). Composition and lipid spatial distribution of HDL particles in subjects with low and high HDL-cholesterol. Journal of Lipid Research, 51 (8), 2341-2351.
Lankinen, M. A. , Schwab, U. S. , Gopalacharyulu, P. , Seppänen-Laakso, T. E. V. T. R. C. o. F. E. F. A. I. 5. F. t. A. , Yetukuri, L. , Sysi-Aho, M. , Kallio, P. , Suortti, T. M.
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(2010). Dietary carbohydrate modification alters serum metabolic profiles in individuals with the metabolic syndrome. NMCD. Nutrition Metabolism and Cardiovascular Diseases, 20 (4), 249-57.
Leskinen, T. , Rinnankoski-Tuikka, R. , Rintala, M. , Seppänen-Laakso, T. , Pöllänen, E. , Alen, M. , Sipilä, S. , Kaprio, J.
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(2010). Differences in muscle and adipose tissue gene expression and cardio-metabolic risk factors in the members of physical activity discordant twin pairs. PLoS ONE, 5 (9).
López, M. , Varela, L. , Vázquez, M. J. , Rodríguez-Cuenca, S. , González, C. R. , Velagapudi, V. R. , Morgan, D. A. , Schoenmakers, E.
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(2010). Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance. Nature Medicine, 16 (9), 1001-1008.
Ahola-Erkkilä, S. , Carroll, C. J. , Peltola-Mjösund, K. , Tulkki, V. , Mattila, I. , Seppänen-Laakso, T. , Oresic, M. , Tyynismaa, H.
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(2010). Ketogenic diet slows down mitochondrial myopathy progression in mice. Human Molecular Genetics, 19 (10), 1974-1984.
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Huopaniemi, I. , Suvitaival, T. , Nikkilä, J. , Oresic, M.
& Kaski, S. (2010). Multivariate multi-way analysis of multi-source data. Bioinformatics, 26 (12), i391-i398.
Pluskal, T. , Castillo, S. , Villar-Briones, A.
& Oresic, M. (2010). MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics, 11.
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(2010). Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease. Gastroenterology, 139 (6), 1961-1971.e1.
Oresic, M. (2010). Systems biology strategy to study lipotoxicity and the metabolic syndrome. Biochimica et Biophysica Acta, 1801 (3), 235-239.
Oresic, M. , Lötjönen, J.
& Soininen, H. (2010). Systems medicine and the integration of bioinformatic tools for the diagnosis of Alzheimer's disease. Genome Medicine, 2 (11).
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(2010). The gut microbiota modulates host energy and lipid metabolism in mice. Journal of Lipid Research, 51 (5), 1101-1112.
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(2009). Adaptation and failure of pancreatic beta cells in murine models with different degrees of metabolic syndrome. Disease Models and Mechanisms, 2 (11-12), 582-592.
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(2009). Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome. World Journal of Gastroenterology, 15 (48), 6068-6074.
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Kotronen, A. , Seppänen-Laakso, T. , Westerbacka, J. , Kiviluoto, T. , Arola, J. , Ruskeepää, A. , Oresic, M.
& Yki-Järvinen, H. (2009). Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes, 58 (1), 203-208.
Tang, J. , Tan, C. Y. , Oresic, M.
& Vidal-Puig, A. (2009). Integrating post-genomic approaches as a strategy to advance our understanding of health and disease. Genome Medicine, 1 (3).
Gatfield, D. , Le Martelot, G. , Vejnar, C. E. , Gerlach, D. , Schaad, O. , Fleury-Olela, F. , Ruskeepää, A. , Oresic, M.
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(2009). Integration of microRNA miR-122 in hepatic circadian gene expression. Genes & Development, 23 (11), 1313-26.
de Mello, V. D. F. , Lankinen, M. , Schwab, U. , Kolehmainen, M. , Lehto, S. , Seppänen-Laakso, T. , Oresic, M. , Pulkkinen, L.
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(2009). Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease. Diabetologia, 52 (12), 2612-2615.
Oresic, M. (2009). Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction. NMCD. Nutrition Metabolism and Cardiovascular Diseases, 19 (11), 816-824.
Nath, A. K. , Krauthammer, M. , Li, P. , Davidov, E. , Butler, L. C. , Copel, J. , Katajamaa, M. , Oresic, M.
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(2009). Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. PLoS ONE, 4 (1).
Róg, T. , Martinez-Seara, H. , Munck, N. , Oresic, M. , Karttunen, M.
& Vattulainen, I. (2009). Role of cardiolipins in the inner mitochondrial membrane: insight gained through atom-scale simulations. Journal of Physical Chemistry B, 113 (11), 3413-3422.
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(2009). Serum saturated fatty acids containing triacylglycerols are better markers of insulin resistance than total serum triacylglycerol concentrations. Diabetologia, 52 (4), 684-690.
de Mello, V. D. F. , Erkkilä, A. T. , Schwab, U. S. , Pulkkinen, L. , Kolehmainen, M. , Atalay, M. , Mussalo, H. , Lankinen, M.
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(2009). The effect of fatty or lean fish intake on inflammatory gene expression in peripheral blood mononuclear cells of patients with coronary heart disease. European Journal of Nutrition, 48 (8), 447-455.
Gopalacharyulu, P. V. , Lindfors, E. , Miettinen, J. , Bounsaythip, C. K.
& Oresic, M. (2008). An integrative approach for biological data mining and visualisation. International Journal of Data Mining and Bioinformatics, 2 (1), 54-77.
Mattila, I. , Seppänen-Laakso, T. , Suortti, T.
& Oresic, M. (2008). Application of lipidomics and metabolomics to the study of adipose tissue. Methods in Molecular Biology, 456, 123-130.
Minehira, K. , Young, S. G. , Villanueva, C. J. , Yetukuri, L. , Oresic, M. , Hellerstein, M. K. , Farese, R. V. , Horton, J. D.
& et al.
(2008). Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. Journal of Lipid Research, 49 (9), 2038-2044.
Sirén, H. , Seppänen-Laakso, T.
& Oresic, M. (2008). Capillary electrophoresis with UV detection and mass spectrometry in method development for profiling metabolites of steroid hormone metabolism. Journal of chromatography. B, 871 (2), 375-382.
Oresic, M. , Simell, S. , Sysi-Aho, M. , Näntö-Salonen, K. , Seppänen-Laakso, T. , Parikka, V. , Katajamaa, M. , Hekkala, A.
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(2008). Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. Journal of Experimental Medicine, 205 (13), 2975-2984.
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(2008). Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data. Radiology, 249 (1), 88-96.
Kekkonen, R. , Sysi-Aho, M. , Seppanen-Laakso, T. , Julkunen, I. , Vapaatalo, H. , Oresic, M.
& Korpela, R. (2008). Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults. World Journal of Gastroenterology, 14 (20), 3188-3194.
Nikkilä, J. , Sysi-Aho, M. , Ermolov, A. , Seppänen-Laakso, T. , Simell, O. , Kaski, S.
& Oresic, M. (2008). Gender-dependent progression of systemic metabolic states in early childhood. Molecular Systems Biology, 4.
Pietiläinen, K. H. , Naukkarinen, J. , Rissanen, A. , Saharinen, J. , Ellonen, P. , Keränen, H. , Suomalainen, A. , Götz, A.
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(2008). Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity. PLoS Medicine, 5 (3).
Yetukuri, L. , Ekroos, K. , Vidal-Puig, A.
& Oresic, M. (2008). Informatics and computational strategies for the study of lipids. Molecular Biosystems, 4 (2), 121-127.
Oresic, M. , Hänninen, V. A.
& Vidal-Puig, A. (2008). Lipidomics: a new window to biomedical frontiers. Trends in Biotechnology, 26 (12), 647-652.
Laaksonen, R. , Jänis, M. T.
& Oresic, M. (2008). Lipidomics-based safety biomarkers for lipid-lowering treatments. Angiology, 59 (2 Suppl), 65S-68S.
Pilvi, T. , Seppanen-Laakso, T. , Simolin, H. , Finckenberg, P. , Huotari, A. , Herzig, K. , Korpela, R. , Oresic, M.
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(2008). Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction. World Journal of Gastroenterology, 14 (28), 4462-4472.
Karpanen, T. , Bry, M. , Ollila, H. M. , Seppänen-Laakso, T. , Liimatta, E. , Leskinen, H. , Kivelä, R. , Helkamaa, T.
& et al.
(2008). Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. Circulation Research, 103 (9), 1018-1026.
Schwab, U. , Seppänen-Laakso, T. , Yetukuri, L. , Ågren, J. , Kolehmainen, M. , Laaksonen, D. E. , Ruskeepää, A. , Gylling, H.
& et al.
(2008). Triacylglycerol fatty acid composition in diet-induced weight loss in subjects with abnormal glucose metabolism: the GENOBIN study. PLoS ONE, 3 (7).
Pietiläinen, K. H. , Sysi-Aho, M. , Rissanen, A. , Seppänen-Laakso, T. , Yki-Järvinen, H. , Kaprio, J.
& Oresic, M. (2007). Acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects: a monozygotic twin study. PLoS ONE, 2 (2).
Kolak, M. , Westerbacka, J. , Velagapudi, V. R. , Wågsäter, D. , Yetukuri, L. , Makkonen, J. , Rissanen, A. , Häkkinen, A.
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(2007). Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity. Diabetes, 56 (8), 1960-1968.
Yetukuri, L. , Katajamaa, M. , Medina-Gomez, G. , Seppänen-Laakso, T. , Vidal-Puig, A.
& Oresic, M. (2007). Bioinformatics strategies for lipidomics analysis: characterization of obesity related hepatic steatosis. BMC Systems Biology, 1.
Sysi-Aho, M. , Vehtari, A. , Velagapudi, V. R. , Westerbacka, J. , Yetukuri, L. , Bergholm, R. , Taskinen, M. , Yki-Järvinen, H.
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(2007). Exploring the lipoprotein composition using Bayesian regression on serum lipidomic profiles. Bioinformatics, 23 (13), i519-i528.
Sysi-Aho, M. , Katajamaa, M. , Yetukuri, L.
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(2007). PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism. PLoS Genetics, 3 (4).
Elo, L. L. , Järvenpää, H. , Oresic, M. , Lahesmaa, R.
& Aittokallio, T. (2007). Systematic construction of gene coexpression networks with applications to human T helper cell differentiation process. Bioinformatics, 23 (16), 2096-2103.
Laaksonen, R. , Katajamaa, M. , Päivä, H. , Sysi-Aho, M. , Saarinen, L. , Junni, P. , Lütjohann, D. , Smet, J.
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(2006). A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS ONE, 1.
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Rischer, H. , Oresic, M. , Seppänen-Laakso, T. , Katajamaa, M. , Lammertyn, F. , Ardiles-Diaz, W. , Van Montagu, M. C. E. , Inzé, D.
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(2006). Gene-to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells. Proceedings of the National Academy of Sciences of the United States of America, 103 (14), 5614-5619.
Elo, L. L. , Katajamaa, M. , Lund, R. , Oresic, M. , Lahesmaa, R.
& Aittokallio, T. (2006). Improving identification of differentially expressed genes by integrative analysis of Affymetrix and Illumina arrays. Omics, 10 (3), 369-380.
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& Hänninen, V. (2006). Metabolomic approaches to phenotype characterization and applications to complex diseases. Expert Review of Molecular Diagnostics, 6 (4), 575-585.
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(2005). A comparative evaluation of software for the analysis of liquid chromatography-tandem mass spectrometry data from isotope coded affinity tag experiments. Proteomics, 5 (11), 2748-2760.
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Artiklar, forskningsöversikter
Fang, W. , Santosh, L. , Oresic, M.
& Hyötyläinen, T. (2019). Lipidomes in health and disease: Analytical strategies and considerations. TrAC. Trends in analytical chemistry, 120.
Sen, P.
& Oresic, M. (2019). Metabolic Modeling of Human Gut Microbiota on a Genome Scale: An Overview. Metabolites, 9 (2).
Sen, P. , Kempainen, E.
& Oresic, M. (2018). Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells. Frontiers in Molecular Biosciences, 4.
Posti, J. P. , Dickens, A. M. , Orešič, M. , Hyötyläinen, T.
& Tenovuo, O. (2017). Metabolomics Profiling As a Diagnostic Tool in Severe Traumatic Brain injury. Frontiers in Neurology, 8.
Rodriguez-Cuenca, S. , Pellegrinelli, V. , Campbell, M. , Oresic, M.
& Vidal-Puig, A. (2017). Sphingolipids and glycerophospholipids.: The "ying and yang" of lipotoxicity in metabolic diseases. Progress in lipid research, 66, 14-29.
Marinković, T.
& Oresic, M. (2016). Modeling strategies to study metabolic pathways in progression to type 1 diabetes: Challenges and opportunities. Archives of Biochemistry and Biophysics, 589, 131-7.
Hyötyläinen, T.
& Oresic, M. (2015). Optimizing the lipidomics workflow for clinical studies: practical considerations. Analytical and Bioanalytical Chemistry, 407 (17), 4973-4993.
Hyötyläinen, T.
& Oresic, M. (2014). Systems biology strategies to study lipidomes in health and disease. Progress in lipid research, 55 (1), 43-60.
Hyötyläinen, T. , Bondia-Pons, I.
& Oresic, M. (2013). Lipidomics in nutrition and food research. Molecular Nutrition & Food Research, 57 (8), 1306-1318.
Denkert, C. , Bucher, E. , Hilvo, M. , Salek, R. , Oresic, M. , Griffin, J. , Brockmöller, S. , Klauschen, F.
& et al.
(2012). Metabolomics of human breast cancer: new approaches for tumor typing and biomarker discovery. Genome Medicine, 4 (4).
Seppänen-Laakso, T.
& Oresic, M. (2009). How to study lipidomes. Journal of Molecular Endocrinology, 42 (3), 185-190.
Jänis, M. T. , Laaksonen, R.
& Oresic, M. (2008). Metabolomic strategies to identify tissue-specific effects of cardiovascular drugs. Expert Opinion on Drug Metabolism & Toxicology, 4 (6), 665-680.
Katajamaa, M.
& Oresic, M. (2007). Data processing for mass spectrometry-based metabolomics. Journal of Chromatography A, 1158 (1-2), 318-328.
Curtis, R. K. , Oresic, M.
& Vidal-Puig, A. (2005). Pathways to the analysis of microarray data. Trends in Biotechnology, 23 (8), 429-435.
Kapitel i böcker, del av antologier
Lamichhane, S. , Sen, P. , Dickens, A. M. , Hyötyläinen, T.
& Orešič, M. (2018). An Overview of Metabolomics Data Analysis: Current Tools and Future Perspectives.
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Joaquim Jaumot; Carmen Bedia; Romà Tauler, Data Analysis for Omic Sciences: Methods and Applications (ss. 387-413).
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