Om Ignacio Rangel
Microbial ecology in Health and Disease
The human body in general and the gastrointestinal (GI) tract in particular can be seen as complex ecological environments. They are ground for a wide and dynamic range of host-microbe interactions. I am a microbiologist with special interest on microbial ecology in human and natural environments. During the last years I have focused my research on the microbiota of the GI tract. An increasing number of investigations have demonstrated the importance of the gut microbiota in shaping physiological, metabolic, immunological and even neurological processes of the host. Likewise, diet, ageing or diseases have been associated with the increase or decrease, in some cases to almost levels of disappearance, in the abundance of some members of the microbiota. My research interest is focused on two main aspects:
1) understanding the mechanisms of commensal bacteria and traditional probiotics (such as Lactobacillus rhamnosus GG) as well as members of the so-called next-generation probiotics (as Akkermansia muciniphila and Fecalibacterium prausnitzii) behind their positive interactions with the host.
2) as well as deciphering the roles of the microbiota in a healthy gut, two gastrointestinal diseases are central in my research: irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). Both have high incidence rates in Northern Europe, United Kingdom and North America. My investigation covers the phylogenetic and functional profiling of the gut microbiota in these diseases.
The aim is to determine which microorganisms are present in the GI tract of patients suffering these diseases, but above all to understand what are their functional roles and ways of interaction with the host both at local and at systemic level.
Research Funding Bodies
Lantmännen, Swedish agricultural cooperative
Artiklar i tidskrifter
- Bachmann, R. , Van Hul, M. , Baldin, P. , Léonard, D. , Delzenne, N. M. , Belzer, C. , Ouwerkerk, J. P. , Repsilber, D. & et al. (2022). Akkermansia muciniphila Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism. Cells, 11 (17).
- Rode, J. , Yang, L. , König, J. , Hutchinson, A. , Wall, R. , Venizelos, N. , Brummer, R. J. , Rangel, I. & et al. (2021). Butyrate Rescues Oxidative Stress-Induced Transport Deficits of Tryptophan: Potential Implication in Affective or Gut-Brain Axis Disorders. Neuropsychobiology, 80 (3), 253-263.
- Björkqvist, O. , Rangel, I. , Serrander, L. , Magnusson, C. , Halfvarson, J. , Norén, T. & Bergman-Jungeström, M. (2021). Faecalibacterium prausnitzii increases following fecal microbiota transplantation in recurrent Clostridioides difficile infection. PLOS ONE, 16 (4).
- Fart, F. , Rajan, S. K. , Wall, R. , Rangel, I. , Ganda Mall, J. P. , Tingö, L. , Brummer, R. J. , Repsilber, D. & et al. (2020). Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults. Nutrients, 12 (9).
- Björkqvist, O. , Repsilber, D. , Seifert, M. , Brislawn, C. , Jansson, J. , Engstrand, L. , Rangel, I. & Halfvarson, J. (2019). Alterations in the relative abundance of Faecalibacterium prausnitzii correlate with changes in fecal calprotectin in patients with ileal Crohn's disease: a longitudinal study. Scandinavian Journal of Gastroenterology, 54 (4), 577-585.
- Engelsöy, U. , Rangel, I. & Demirel, I. (2019). Impact of Proinflammatory Cytokines on the Virulence of Uropathogenic Escherichia coli. Frontiers in Microbiology, 10.
- Björkqvist, O. , Repsilber, D. , Seifert, M. , Engstrand, L. , Rangel, I. & Halfvarson, J. (2018). Increasing abundance of faecalibacterium prausnitzii is associated with decreased intestinal inflammation in Crohn's disease: A longitudinal study. Journal of Crohn's & Colitis, 12 (Suppl. 1), S468-S469.
- Neumann, G. , Wall, R. , Rangel, I. , Marques, T. M. & Repsilber, D. (2018). Qualitative modelling of the interplay of inflammatory status and butyrate in the human gut: a hypotheses about robust bi-stability. BMC Systems Biology, 12 (1).
- Wall, R. , Marques, T. , Edebol-Carlman, H. , Sundin, J. , Vumma, R. , Rangel, I. & Brummer, R. J. (2017). Altered expression of membrane transporters in colonic mucosa of patients with Irritable Bowel Syndrome (IBS) and Post-infectious (PI)-IBS compared to healthy subjects. Neurogastroenterology and Motility, 29 (Suppl. 2), 107-108.
- Demirel, I. , Rangel, I. , Petersson, U. , Persson, K. & Kruse, R. (2017). Transcriptional Alterations of Virulence-Associated Genes in Extended Spectrum Beta-Lactamase (ESBL)-Producing Uropathogenic Escherichia coli during Morphologic Transitions Induced by Ineffective Antibiotics. Frontiers in Microbiology, 8.
- Rangel, I. , Ganda Mall, J. P. , Roger, W. , Sjöberg, F. & Hultgren-Hörnquist, E. (2016). Degree of colitis correlates with microbial composition and cytokine responses in colon and caecum of Gαi2-deficient mice. FEMS Microbiology Ecology, 92 (7).
- Sundin, J. , Rangel, I. , Fuentes, S. , Jong, H. , Hultgren-Hörnquist, E. , de Vos, W. M. & Brummer, R. (2015). Altered faecal and mucosal microbial composition in post-infectious irritable bowel syndrome patients correlates with mucosal lymphocyte phenotypes and psychological distress. Alimentary Pharmacology and Therapeutics, 41 (4), 342-351.
- Sundin, J. , Rangel, I. , Repsilber, D. & Brummer, R. (2015). Cytokine Response after Stimulation with Key Commensal Bacteria Differ in Post-Infectious Irritable Bowel Syndrome (PI-IBS) Patients Compared to Healthy Controls. PLOS ONE, 10 (9).
- Rangel, I. , Sundin, J. , Fuentes, S. , Repsilber, D. , de Vos, W. M. & Brummer, R. J. (2015). The relationship between faecal-associated and mucosal-associated microbiota in irritable bowel syndrome patients and healthy subjects. Alimentary Pharmacology and Therapeutics, 42 (10), 1211-1221.
- Sundin, J. , Rangel, I. , Kumawat, A. K. , Hultgren-Hörnquist, E. & Brummer, R. J. (2014). Aberrant mucosal lymphocyte number and subsets in the colon of post-infectious irritable bowel syndrome patients. Scandinavian Journal of Gastroenterology, 49 (9), 1068-1075.
- Rangel, I. , Ganda-Mall, J. , Sjöberg, F. , Willen, R. & Hultgren-Hörnquist, E. (2013). Alterations in gut microbiota composition in tissues and feces of G alpha i2(-/-) mice with colitis in parallel with enhanced cytokine secretion. Immunology, 140, 168-169.
- Sjöberg, F. , Nowrouzian, F. , Rangel, I. , Hannoun, C. , MooreA, E. , Adlerberth, I. & Wold, A. E. (2013). Comparison between terminal-restriction fragment length polymorphism (T-RFLP) and quantitative culture for analysis of infants' gut microbiota. Journal of Microbiological Methods, 94 (1), 37-46.
- Götlind, Y. Y. , Fritsch Fredin, M. , Kumawat, A. K. , Strid, H. , Willén, R. , Rangel, I. , Bland, P. W. & Hultgren Hörnquist, E. (2013). Interplay between Th1 and Th17 effector T cell pathways in the pathogenesis of spontaneous colitis and colon cancer in the Gai2-deficient mouse. International Immunology, 25 (1), 35-44.
- Sundin, J. , Brummer, R. , Hultgren Hörnquist, E. & Rangel, I. (2012). Increased number of double positive CD3+ CD8+ CD4+ lamina propria T lymphocyte in gut mucosa of post infectious IBS patients compared to healthy controls. Neurogastroenterology and Motility, 24 (Suppl. 2), 104-105.
- König, J. , Rangel, I. & Brummer, R. J. (2013). The Role of Lactic Acid Bacteria in the Pathophysiology and Treatment of Irritable Bowel Syndrome (IBS). Food and Nutrition Sciences, 4 (11), 27-39.
- Athlin, S. , Berglind, Å. , Dahlberg, K. , Ehnfors, C. , Eklund, D. , Pettersson, C. , Rangel, I. , Rolland, A. & et al. Athlin, S. (ed.) , Berglind, Å. (ed.) , Dahlberg, K. (ed.) , Ehnfors, C. (ed.) , Eklund, D. (ed.) , Pettersson, C. (ed.) , Rangel, I. (ed.) , Rolland, A. (ed.) , Sirsjö, A. (ed.) & Venizelos, N. (ed.) (2019). Örebro University’s Nobel Day Festivities: Book of abstracts, 2019. Örebro: Örebro universitet.
Kapitel i böcker, del av antologier
- König, J. , Ganda-Mall, J. , Rangel, I. , Edebol-Carlman, H. & Brummer, R. J. (2015). The Role of the Gut Microbiota in Brain Function. I: Koen Venema & Ana Paula do Carmo, Probiotics and Prebiotics: Current Research and Future Trends. Poole, UK: Caister Academic Press.
- Gorreja, F. , Rangel, I. , Rush, S. , Wall, R. , De Vos, W. M. & Brummer, R. J. (2018). Double-blind cross-over trial reveals human mucosal transcriptome responses to variants of LGG administration in vivo. I: Peter Konturek, Targeting microbiota 6th World congress on targeting microbiota towards clinical revolution. Konferensbidrag vid 6th World Congress on Targeting Microbiota, Porto, Portugal, October 28-30, 2018. Porto, Portugal: ISM.
- Sundin, J. , Rangel, I. , Repsilber, D. & Brummer, R. J. Cytokine response after stimulation with key commensal bacteria differ in post-infectious irritable bowel syndrome (PI-IBS) patients compared to healthy subjects.
- Rangel, I. , Sundin, J. , Fuentes, S. , Repsilber, D. , de Vos, W. M. & Brummer, R. J. Mucosal-associated microbiota differs less than fecal-associated microbiota between Irritable Bowel Syndrome patients and healthy subjects.